Quantitation of Inflammatory Activity in Interstitial Pneumonitis by Bronchofiberscopic Pulmonary Lavage

Davis, Gerald S.; Brody, Arnold R.; Landis, John N.; Graham, W. G.; Craighead, John E.; Green, G.M.

doi:10.1378/chest.69.2_supplement.265

Cited by 22 publications

(1 citation statement)

References 4 publications

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“…15. 18-20, 25, 31], Signifi cantly, it has provided a relatively safe and repeatable access to cellular material at the pulmonary surface and within the alveolar spaces, allowing accurate correlation with histological observations and contributing a valuable diagnostic parameter to studies on human diseases [11]. Following the initial application of this technique to experimental animals, there is now an increasing amount of data available from studies on humans (2-5, 10, 11, 13, 21, 30, 33], These have tended to concentrate on either the chemical and immunological characteristics of secre tions from the lower respiratory tract, or the composition and function of cellular compo nents, particularly the lymphocytes [1,7,9,27,28,35].…”

Section: Introductionmentioning

confidence: 99%

Studies on Bronchoalveolar Cells in Human Diseases

Lenzini¹,

Heather²,

Rottoli³

et al. 1980

Respiration

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Data are presented from light and electron microscopic studies on bronchoalveolar lavage (BAC) in sarcoidosis, with particular emphasis on the ultrastructural morphology and functional characteristics of pulmonary macrophages (PM) and small mononuclear cells (SMC). Light microscopy showed an average of over 77% of the BAC to be PM,range 99–51%. SMC populations were also extremely variable. These variations may relate directly to the degree of disease activity. Electron microscopy demonstrated a wide range of morphological and implied functional (biosynthetic and phagocytic) characteristics of PM. Some of these are morphologically comparable to cells found in tissue granulomata. Our ultrastructural study has shown that the SMC population is made up of lymphocytes, monocytes and cells with intermediate characteristics (precursors)

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Section: Introductionmentioning

confidence: 99%

Studies on Bronchoalveolar Cells in Human Diseases

Lenzini¹,

Heather²,

Rottoli³

et al. 1980

Respiration

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Pathologie und Radiologie der Lungenfibrosen

Rau¹

1989

Handbuch Der Medizinischen Radiologie / Encyclopedia of Medical Radiology

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Contribution � l'�tude des liquides de lavage alv�olaire

Chomette

Leclerc

Raphaël

et al. 1979

Virchows Arch. A Path. Anat. and Histol.

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Light cytology, enzymology, immunofluorescence and scanning electron microscopy have been performed on 49 bronchoalveolar fluids recovered by bronchoscopic lavage. The patients had the following lung diseases: infectious pneumonitis (19 cases), pulmonary fibrosis (13 cases) including 5 sarcoïdosis, 3 idiopathic pulmonary fibrosis and 5 silicosis, hypersensitivity pneumonitis (5 cases) and miscellaneous lung tumors (12 cases). Cytologic studies in comparison with clinical aspects show 4 groups: Group I (chronic bronchopneumopathy and inactive fibrosis) presents numerous cells but few lymphocytes (less than 5%); in Group II (evolutive fibrosis) have an increase percentage of lymphocytes (20%); in Group III (hypersensitivity pneumonitis) is observed a very high percentage of lymphocytes (45%); and in Group IV (cancerous lung diseases) values are not far from normal percentage except for lymphomas. Small macrophages (diameter: 10 microns) with a central monocytoïde nucleus and few cytoplasma, are abundant in groups II and III where lymphocytosis is higher. Scanning electron microscopy shows irregular and rough surface, and numerous spontaneous adherences with erythrocytes, lymphocytes, or bacterias. Enzymatic activity (acid hydrolase, esterase, oxydase) increases in these cells. Lymphocytes have a smooth surface ovocative of T origin which is confirmed by granular acid phosphatase positivity and rosette forming test. Immunofluorescence shows positive granules with IgG, C1Q and C3 in macrophages only for Groups II and III while free immunoglobulins were present in the recovered lavage fluid.

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Quantitation of Inflammatory Activity in Interstitial Pneumonitis by Bronchofiberscopic Pulmonary Lavage

Cited by 22 publications

References 4 publications

Studies on Bronchoalveolar Cells in Human Diseases

Studies on Bronchoalveolar Cells in Human Diseases

Pathologie und Radiologie der Lungenfibrosen

Contribution � l'�tude des liquides de lavage alv�olaire

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