Quantitation of in vivo human folate metabolism

Abstract

Across subjects, folate absorption, bile folate flux, and body folate stores were larger than prior estimates. Marrow folate uptake and pteroylpolyglutamate synthesis, recycling, and catabolism are saturable processes. Visceral pteroylpolyglutamate was an immediate precursor of plasma p-aminobenzoylglutamate. The model is a working hypothesis with derived features that are explicitly model-dependent. It successfully quantitated folate metabolism, encouraging further rigorous testing.

Maternal folic acid consumption during gestation and its long-term effects on offspring's liver: a systematic review

“…29 The concentrations of folates are higher in red blood cells than in plasma. 30 Folates may be retained in red blood cells due to its binding to hemoglobin. In the hepatocytes, the transport of folate is ATPdependent.…”

Folatos y vitamina B12 en la salud humana

“…Aunque existen reservas hepáticas cercanas al 50% del total, en deficiencia estas sólo satisfacen los requerimientos por unos meses 1,7,8 . La cinética del metabolismo de folatos indica que los procesos de captación, síntesis, reciclaje y catabolismo son saturables 9 . La B 12 se absorbe en el íleon distal (Figura 3).…”

“…En los últimos años se ha desarrollado la medición de holo-transcobalamina, marcador precoz de la función de B 12 . Estas pruebas tienen limitaciones técnicas o biológicas que afectan la sensibilidad, especificidad y valor predictivo (Tabla 5) 9,[48][49][50] . Por este motivo, se privilegia el uso combinado de éstas.…”

Research goals for folate and related B vitamin in Europe

“…Studies using stable isotopically labelled folates and mathematical modelling techniques have demonstrated new insights into folate absorption and metabolism (Gregory et al, 2005;Wright et al, 2005). With the use of radioactive folate tracers and accelerator mass spectrometry, quantitative models of in vivo folate metabolism can be further developed and tested (Lin et al, 2004).…”