Quantitation of fibrinolytic agents released in tissue culture

Clinical pharmacology of aminocaproic and tranexamic acids

“…The fibrinolytic activity of homogenates of the tissues was measured on unheated fibrin plates and the concentration of AMCA and EACA with highvoltage electrophoresis. AMCA was given [36][37][38][39][40][41][42][43][44][45][46][47][48] hours before the operation in four doses of about 10-20 mg/kg bodyweight each. The corresponding dose of EACA was 100 mg/kg.…”

Clinical pharmacology of aminocaproic and tranexamic acids

“…The fibrinolytic activity of homogenates of the tissues was measured on unheated fibrin plates and the concentration of AMCA and EACA with highvoltage electrophoresis. AMCA was given [36][37][38][39][40][41][42][43][44][45][46][47][48] hours before the operation in four doses of about 10-20 mg/kg bodyweight each. The corresponding dose of EACA was 100 mg/kg.…”

Dowling oration 1975. FIBRINOLYSIS AND VASCULITIS

“…The plasminogen activator has not been adequately identified biochemically but a crude form is certainly extractable from the lining of blood vessels especially venous endothelium (Astrup, 1966). It is rather odd that the endothelium of large arteries has little fibrinolytic activity (Astrup 1966) but the endothelium of large veins and most small vessels are rich sources of plasminogen activator (Pandolfi, 1970;Astedt, Pandolfi & Nilsson, 1971). In the skin, the deep dermal veins and capillaries are more active than the subpapillary vessels (Haustein, 1966;Turner & Ryan, 1969).…”