Quantitation of calcitonin gene‐related peptide mrna and neuronal cell death in facial motor nuclei following axotomy and 633 nm low power laser treatment

Snyder, Sara K.; Byrnes, Kimberly R.; Borke, Rosemary C.; Sánchez, A; Anders, Juanita J.

doi:10.1002/lsm.10098

Cited by 67 publications

(53 citation statements)

References 42 publications

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“…The He-Ne laser (632.8Nm) in the red emission region of the electromagnetic spectrum was the most studied wavelength on the biomodulation of biological response in the repair process 16,17 . Lately, others wavelengths are being developed and researched, like the lasers that emit radiation in the bands of 650-830Nm (GaAlAs) 18,19 and that of 904Nm (GaAs) 20,21 . It was adopted the 660Nm GaAlAs laser because of its low intensity and for having a wavelength often used in clinical practice, besides that, there are no significant number of previous studies over this wave length and its effects on peripheral nerve regeneration 22 .…”

Section: Discussionmentioning

confidence: 99%

“…It is important to highlight that this parameter is widely variable in the researches using laser therapy on nerve regeneration. The use of LILT as a therapeutic method still has contradictions and its biomodulator effect over the peripheral nerves is obscure yet, since some studies show positive results 18,21,22 while others indicate that the laser has no influence over the peripheral nerves regeneration 19 . The use of the gait track is a very common method of assessment 23 that has a wide applicability on experimental researches for its easy execution and low cost of the method.…”

Section: Discussionmentioning

confidence: 99%

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Efeito da terapia com laser de arsenieto de gálio e alumínio (660Nm) sobre a recuperação do nervo ciático de ratos após lesão por neurotmese seguida de anastomose epineural: análise funcional

Fa¹,

Acg²,

Ra³

et al. 2008

Rev. bras. fisioter.

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© Revista Brasileira de FisioterapiaEffect of gallium-aluminum-arsenide laser therapy (660Nm) on recovery of the sciatic nerve in rats following neurotmesis lesion and epineural anastomosis: functional analysis Efeito da terapia com laser de arsenieto de gálio e alumínio (660Nm) sobre a recuperação do nervo ciático de ratos após lesão por neurotmese seguida de anastomose epineural: análise funcional AbstractContext: Peripheral nerve injuries result in sensory and motor losses in the innervated area and can hinder individuals' daily activities. Objective:The objective was to analyze the influence of applying gallium-aluminum-arsenide (GaAlAs) laser (660Nm) on the functional recovery of the sciatic nerve in rats. Methods: The sciatic nerve of 12 Wistar rats was subjected to injury consisting of neurotmesis and epineural anastomosis. The rats were divided into two groups: control and laser therapy. After the injury, a GaAlAs laser was used (660Nm, 4J/cm², 26.3mW and 0.63cm² beam) at three equidistant points on the injury, for 20 days. Footprint impressions were obtained from the animals before and seven, 14 and 21 days after the surgical procedure and the sciatic functional index (SFI) was calculated. Results:Comparison of the SFI did not show any significant difference (p>0.05) between the two groups. Conclusions: The parameters and methods used for the laser therapy did not produce any effect on the SFI over the period evaluated.Key words: nerve regeneration; low-level laser therapy; sciatic nerve. ResumoContextualização: As lesões nervosas periféricas podem comprometer atividades diárias de um indivíduo e resultam em perda da sensibilidade e motricidade do território inervado. Objetivo: Com o intuito de acelerar os processos regenerativos, objetivou-se analisar a influência da aplicação do laser de arsenieto de gálio e alumínio (AsGaAl, 660Nm) sobre a recuperação funcional do nervo ciático de ratos. Materiais e métodos: O nervo ciático de 12 ratos Wistar foi submetido à lesão por neurotmese e anastomose epineural e divididos em dois grupos: controle e laserterapia. Após a lesão, utilizou-se o laser de GaAlAs, 660Nm, 4J/cm Palavras-chave: regeneração nervosa; terapia a laser de baixa intensidade; nervo ciático.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Efeito da terapia com laser de arsenieto de gálio e alumínio (660Nm) sobre a recuperação do nervo ciático de ratos após lesão por neurotmese seguida de anastomose epineural: análise funcional

Fa¹,

Acg²,

Ra³

et al. 2008

Rev. bras. fisioter.

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“…Thus, the model of crush lesion has been adopted by several authors that emphasize the fact that the crush preserves, at least in part, the nerve structure, facilitating its regeneration, and for not demonstrating the necessity of realizing a suture, what implicates in previous training in microsurgical techniques and the availability of adequate instrumental and material, in general, with high cost 1 . Studies on molecular biology have sustained that the laser therapy increases the rates of nerve regeneration, reinnervation and neuronal survival after the rupture of axons 5 . The molecular base that would justify the effectiveness of the laser therapy on the nerve regeneration has not been clear yet.…”

Section: Introductionmentioning

confidence: 99%

Histological analysis of low-intensity laser therapy effects in peripheral nerve regeneration in Wistar rats

et al. 2011

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Purpose: Analyze the influence of low-intensity laser therapy in the sciatic nerve regeneration of rats submitted to controlled crush through histological analysis. Methods: Were used 20 Wistar rats, to analyze the influence of low-intensity laser therapy in the sciatic nerve regeneration, where the injury of the type axonotmesis was induced by a haemostatic clamp Crile (2nd level of the rack). The animals were randomly distributed in 2 groups. Control group (CG n = 10) and Laser group (LG n = 10). These were subdivided in 2 subgroups each, according to the euthanasia period: (CG14 -n = 5 and CG21 -n = 5) and (LG14 -n = 5 and LG21 -n = 5). At the end of treatment, the samples were removed and prepared for histological analysis, where were analyzed and quantified the following findings: Schwann cells, myelinic axons with large diameter and neurons. Results: In the groups submitted to low-intensity laser therapy, were observed an increase in the number of all analyzed aspects with significance level. Conclusion: The irradiation with low intensity laser (904nm) influenced positively the regeneration of the sciatic nerve in Wistar rats after being injured by crush (axonotmesis), becoming the nerve recovery more rapid and efficient.

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“…In using high power surgical lasers, the collimation of laser light leads to the emission of a narrow, intense beam of light and is used for precise tissue destruction (photothermal effect). However, in LLLT, light radiation intensities are so low that the resulting biological effects are ascribable to physical or chemical changes associated with the interaction of cells and tissues with the laser radiation, and not simply to a result of heating (Snyder, Byrnes et al 2002;Gigo-Benato, Geuna et al 2005). …”

Section: A Brief Review On Biological Effects Of Low Level Therapeutimentioning

confidence: 99%

Non-Thermal, Non-Ablative CO2 Laser Therapy (NACLT): A New Approach to Relieve Pain in Some Painful Oral Diseases

Zand¹

2012

CO2 Laser - Optimisation and Application

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Quantitation of calcitonin gene‐related peptide mrna and neuronal cell death in facial motor nuclei following axotomy and 633 nm low power laser treatment

Abstract: These findings demonstrate that 633 nm laser light upregulates CGRP mRNA and support the theory that laser irradiation increases the rate of regeneration, target reinnervation, and neuronal survival of the axotomized neuron.

Cited by 67 publications

References 42 publications

Efeito da terapia com laser de arsenieto de gálio e alumínio (660Nm) sobre a recuperação do nervo ciático de ratos após lesão por neurotmese seguida de anastomose epineural: análise funcional

Efeito da terapia com laser de arsenieto de gálio e alumínio (660Nm) sobre a recuperação do nervo ciático de ratos após lesão por neurotmese seguida de anastomose epineural: análise funcional

Histological analysis of low-intensity laser therapy effects in peripheral nerve regeneration in Wistar rats

Non-Thermal, Non-Ablative CO2 Laser Therapy (NACLT): A New Approach to Relieve Pain in Some Painful Oral Diseases

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