Quantitation of Anterior Chamber Inflammation and Its Response to Therapy

Bolliger, Glen A.; Kupferman, Allan; Leibowitz, Howard M.

doi:10.1001/archopht.1980.01020031100019

Cited by 8 publications

(1 citation statement)

References 16 publications

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“…the severity of AC infl ammation and of the integrity of the blood-aqueous barrier. 32 In the present study, clinical scores and cell counts in the AC suggest that TA implants effectively inhibited AC leukocyte infi ltration. Similarly, clinical scores of AC fl are and aqueous protein levels indicated that TA implants have a protective effect on blood-aqueous barrier.…”

Section: Discussionmentioning

confidence: 50%

Biodegradable Intrascleral Implant of Triamcinolone Acetonide in Experimental Uveitis

Shin

Park

et al. 2009

Journal of Ocular Pharmacology and Therapeutics

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Section: Discussionmentioning

confidence: 50%

Biodegradable Intrascleral Implant of Triamcinolone Acetonide in Experimental Uveitis

Shin

Park

et al. 2009

Journal of Ocular Pharmacology and Therapeutics

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Glaukom bei entzündlichen Augenerkrankungen

Shields

1993

Glaukom

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Inflammatory response in the rabbit eye after intraocular implantation with poly(methyl methacrylate) and heparin surface modified intraocular lenses

Lundgren¹,

Ocklind²,

Holst³

et al. 1992

Journal of Cataract and Refractive Surgery

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Early inflammatory responses in rabbit eyes after anterior chamber implantation with poly(methyl methacrylate) (PMMA) and heparin surface modified intraocular lenses (IOLs) and after cataract extraction and implantation with PMMA and heparin surface modified intraocular lenses (IOLs) were investigated between 1 and 30 days postoperatively. The number of white blood cells in the aqueous humor, the distribution of white blood cell subsets, and the interleukin-1 (IL-1b) levels were studied. At one day postoperatively, there was a significantly smaller number of white blood cells in eyes with heparin surface modified IOLs than in eyes with PMMA IOLs after both anterior chamber implantation and cataract surgery and capsular bag implantation. At one day postoperatively, 87% of the cell population in eyes with PMMA IOLs were neutrophilic granulocytes. Two days later the neutrophilic granulocytes had decreased to 13% and at seven days they were gone. At 14 days the frequency was 7% and at 30 days it was 27%. The fraction of monocytes/macrophages in the cell population was 9% (day 1), 79% (day 3), 94% (day 7), 81% (day 14), and 72% (day 30). The fraction of lymphocytes was low throughout the test period (1% to 10%). The percentages were almost the same in eyes with heparin surface modified IOLs and there was no significant difference in the distribution of white blood cell subsets between the two lens materials. The IL-1 was not detected in any of the samples (day 3, day 7, and day 30). Inactivated macrophages and/or levels under detection limits could be the reason.(ABSTRACT TRUNCATED AT 250 WORDS)

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Quantitation of Anterior Chamber Inflammation and Its Response to Therapy

Cited by 8 publications

References 16 publications

Biodegradable Intrascleral Implant of Triamcinolone Acetonide in Experimental Uveitis

Biodegradable Intrascleral Implant of Triamcinolone Acetonide in Experimental Uveitis

Glaukom bei entzündlichen Augenerkrankungen

Inflammatory response in the rabbit eye after intraocular implantation with poly(methyl methacrylate) and heparin surface modified intraocular lenses

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