Quantitation of adrenaline and noradrenaline from human plasma by combined gas chromatography—high-resolution mass fragmentography

Jacob, K.; Vogt, Wolfgang; Knedel, M.; Schwertfeger, G.

doi:10.1016/s0378-4347(00)81888-5

Cited by 24 publications

(3 citation statements)

References 9 publications

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“…Methods that have previously been successfully applied to the analysis of /3-hydroxyphenylethylamines in tissue are radioenzymatic assays for phenylethanolamine, m-and p-octopamine, noradrenaline, and adrenaline (3-14), gas chromatography-mass spectrometry for phenylethanolamine, octopamine, metanephrine, normetanephrine, noradrenaline, and adrenaline (15)(16)(17)(18)(19)(20), and fluorimetry for noradrenaline and adrenaline (21)(22)(23). The radioenzymatic methods are capable of detecting as little as 10 pg (100 fmol) of an amine, but they have some limitations.…”

mentioning

confidence: 99%

Thin-layer chromatographic and high resolution mass spectrometric determination of .beta.-hydroxyphenylethylamines in tissues as dansyl-acetyl derivatives

Durden¹,

Juorio²,

Davis³

1980

Anal. Chem.

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mentioning

confidence: 99%

Thin-layer chromatographic and high resolution mass spectrometric determination of .beta.-hydroxyphenylethylamines in tissues as dansyl-acetyl derivatives

Durden¹,

Juorio²,

Davis³

1980

Anal. Chem.

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“…After stirring for 3 h at 60°C, the mixture is cooled and trifl uoroacetic anhydride is added (60°C, 3 h). A similar two-step derivatization was used, for example, for the detection and determination of catecholamines, 63 ephedra-alkaloids (ephedrine, norephedrine, pseudoephedrine and other analogs) 64 or other β 2 -agonists 65…”

Section: Mixed Derivatives Of Amino Alcohols and Amino Ketonesmentioning

confidence: 99%

Derivatization in Mass Spectrometry—6. Formation of Mixed Derivatives of Polyfunctional Compounds

Заикин

Halket

2005

Eur J Mass Spectrom (Chichester)

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The review describes chemical transformations of multifunctional compounds (amino acids and peptides, amino alcohols, amino thiols, hydroxy acids, oxo acids, oxo alcohols, compounds containing simultaneously three or more different groups etc.) by using step-wise or one-step modification or protection of functional groups. Some chemical aspects of mixed derivatization performed for improving the physical-chemical properties and mass spectral characteristics are discussed. Application of mixed derivatization to qualitative and quantitative analysis of various multifunctional compounds mainly in biological fluids and other matrices by gas chromatography/mass spectrometry in electron ionization, chemical ionization, negative-ion chemical ionization and selected ion monitoring modes is considered.

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“…65 Karoum et al examined the usefulness of pentafluoropropionic and heptafluorobutyric anhydride as derivatization reagents with ECD or GC-MS.& They developed the measurement of catecholamines as their pentafluoropropionic derivatives in urine with ECD.67 Recently, the mass spectrometric behavior of pentafluoropropionic derivatives of catecholamine standards has been examined,68 but no adaptation for determination of plasma catecholamines with this derivatization method has been published. Jacob et al 69 succesfully quantified epinephrine and norepinephrine from human plasma by GC-MS using N-trifluoroacetyl-N-trimeth ylsilylderivatives. Plasma samples had to be prepurified with aluminum oxide before derivatization.…”

Section: Gas Chromatography Using Mass Spectrometry or Electron Camentioning

confidence: 99%

Plasma Catecholamines: Laboratory Aspects

Nyyssönen

1989

Critical Reviews in Clinical Laboratory Sciences

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In this review the methods used for analysis of plasma catecholamines in clinical chemical laboratories are discussed. The physiology of catecholamines as well as their measuring indications are discussed, together with concise evaluation of the methods most commonly used, namely indirect radioenzymatic assays or direct determinations by high-performance liquid chromatography combined with either electrochemical or fluorometric detection. The main advantage of radioenzymatic assay is its sensitivity and thus the need for only a small sample. Liquid chromatographic methods in general are less tedious, relatively rapid, and cheap, and omit the use of radionuclides. Both of these methods, however, are subject to a number of analytical errors, which can only be avoided by proper development of methods and skilled use of these methods. Little routine work is done using either radioimmunoassay or gas-chromatography.

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Quantitation of adrenaline and noradrenaline from human plasma by combined gas chromatography—high-resolution mass fragmentography

Cited by 24 publications

References 9 publications

Thin-layer chromatographic and high resolution mass spectrometric determination of .beta.-hydroxyphenylethylamines in tissues as dansyl-acetyl derivatives

Thin-layer chromatographic and high resolution mass spectrometric determination of .beta.-hydroxyphenylethylamines in tissues as dansyl-acetyl derivatives

Derivatization in Mass Spectrometry—6. Formation of Mixed Derivatives of Polyfunctional Compounds

Plasma Catecholamines: Laboratory Aspects

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