Quantitation in Positron Emission Computed Tomography

Hoffman, Edward J.; Huang, Sung‐Cheng; Plummer, D.; Phelps, Michael E.

doi:10.1097/00004728-198210000-00022

Cited by 185 publications

(156 citation statements)

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“…It may cause significant underestimation in the measurement of radioactivity concentration in small brain areas, and furthermore creates systematic errors in evaluating quantitative physiological parameters (Hoffman et al, 1979). In our studies, there are two aspects that may suppress the partial volume effect systematic errors: one is the use of cerebellum as the reference tissue in equation (2); the other is the comparison of the right (lesioned) and the left (control) brain regions of the same rats by calculating percent differences in equation (3).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Four Pyridine Analogs to Characterize 6-OHDA-Induced Modulation of mGluR5 Function in Rat Brain Using microPET Studies

Zhu

Wang

et al. 2007

J Cereb Blood Flow Metab

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Micro-positron emission tomography imaging studies were conducted to characterize modulation of metabotropic glutamate subtype-5 receptor (mGluR5) function in a 6-hydroxydopamine (6-OHDA)-induced rat model of Parkinson's disease using four analogical PET ligands: 2-A total of 45 positron emission tomography (PET) imaging studies were conducted on nine male Sprague-Dawley rats within 4 to 6 weeks after unilateral 6-OHDA lesioning into the right medial forebrain bundle. The severity of the lesion was determined with [ 11 C]CFT ([ 11 C]2-b-carbomethoxy-3-b-(4-fluorophenyl)tropane), a specific and sensitive ligand for imaging dopamine transporter function. The binding potential (BP) images were processed on pixelby-pixel basis by using a method of the distribution volume ratio with cerebellum as a reference tissue. The values for BP were determined on striatum, hippocampus, and cortex. [ 11 C]CFT binding was decreased on the lesioned (right) striatum by 35.4%613.4% compared with the intact left striatum, indicating corresponding loss of presynaptic dopamine terminals. On the same areas of the lesioned striatum, three of the four tested mGluR5 ligands showed enhanced binding characteristics. The average differences between the right and left striatum were 4.4%66.5% (P < 0.05) with [ 11 C]MPEP, À0.1%61.7% (P > 0.05) with [ 11 C]M-MPEP, 3.9%64.6% (P < 0.05) with [ 11 C]M-PEPy, and 6.6%62.7% (P > 0.05) with [ 18 F]M-TEP. The enhanced binding was also observed in the right hippocampus and cortex. These studies showed that glutamatergic neurotransmission might have a complementary role in dopaminergic degeneration, which can be evaluated by in vivo PET imaging.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Four Pyridine Analogs to Characterize 6-OHDA-Induced Modulation of mGluR5 Function in Rat Brain Using microPET Studies

Zhu

Wang

et al. 2007

J Cereb Blood Flow Metab

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“…The first attempts to compensate for PVE using recovery coefficients were made by Hoffman and colleagues [5], who computed a set of recovery coefficients based on known size, shape, and location (within the PET scanner) of the objects being imaged. The same group later extended this approach to predict the recovery coefficients for different brain structures that were approximated using a series of non-overlapping spheres [6].…”

Section: Recovery Coefficient Methodsmentioning

confidence: 99%

“…Likewise, the first partial volume correction (PVC) techniques focused on neurologic PET procedures in which the enhancement of the quantitative capabilities of PET was driven by brain research [5,6]. The most sophisticated PVC strategies rely on an adjunct coregistered structural image in which MR imaging plays a pivotal role because of the better contrast between the gray and white matter compared with CT [7][8][9][10].…”

Section: P O S I T R O N E M I S S I O N T O M O G R a P H Y Pet Clinmentioning

confidence: 99%

Partial Volume Correction Strategies in PET

et al. 2007

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“…Unfortunately, both techniques are highly nonlinear precisely in the heart's dimensions. 16 Variations and combinations of both techniques 22 or model-based techniques 10 may be used to obtain more stable and consistent segmentation results. (3) Global thresholding, which gives only incomplete and very inaccurate boundaries because of nonhomogeneous count profiles.…”

Section: Contour Trackingmentioning

confidence: 99%

Segmentation of gated TI-SPECT images and computation of ejection fraction: A different approach

Brigger

Bacharach

Srinivasan

et al. 1999

Journal of Nuclear Cardiology

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Background. We describe a set of image processing algorithms and mathematical models that can be advantageously used in schemes for the segmentation of thallium-201-single photon emission computed tomography (SPECT) images and for computation of left ventricular ejection fraction (EF).Methods. The system consists of two independent blocs for image segmentation and computation of function. The former is based on a multiresolution elliptical coordinate transformation and dynamic contour tracking. Computation of EF is formulated on the basis of both the endocardial and epicardial contours, and we compare this formulation with that using only the endocardial border for images with low signal-to-noise ratios. The accuracy of border detection was validated against manual border tracing on FDG-PET images, simulated TI-201-SPECT images where the true underlying borders were known, and actual TI-201-SPECT images. Finally, we compared EFs computed for FDG-PET, technetium-99m-SPECT and TI-201--SPECT with those obtained from planar gated blood pool imaging.Results. The automatically obtained results always were within the manual uncertainty range. Agreement between myocardial volumes from positron emission tomography and automatically obtained values from the simulated TI-201-SPECT images was excellent (r = 0.95, n = 32). Agreement between EFs from planar gated blood pool imaging and the other image modalities was good (FDG-PET: y = 5.89 + 1.21x, r = 0.92, see = 6.24, n = 19, Tc-99m-SPECT: y = -3.86 + 1.06x, r = 0.88, see = 7.78, n = 9, TI-201-SPECT: y = 17.8 + 0.81x, r = 0.77, see = 7.44, n = 26). For noisy input data the combined use of information from epicardial and endocardial contours gives more accurate EF values than the traditional formula on the basis of the endocardial contour only.Conclusions. Alternate approaches for segmentation and computation of function have been presented and validated. They might also be advantageously incorporated into other existing techniques. (J Nucl Cardiol 1999;6:286-97.)

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Quantitation in Positron Emission Computed Tomography

Cited by 185 publications

References 0 publications

Evaluation of Four Pyridine Analogs to Characterize 6-OHDA-Induced Modulation of mGluR5 Function in Rat Brain Using microPET Studies

Evaluation of Four Pyridine Analogs to Characterize 6-OHDA-Induced Modulation of mGluR5 Function in Rat Brain Using microPET Studies

Partial Volume Correction Strategies in PET

Segmentation of gated TI-SPECT images and computation of ejection fraction: A different approach

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