Quantifying the relationship between age at diagnosis and breast cancer-specific mortality

Johnson, Helen M.; Irish, William; Muzaffar, Mahvish; Vohra, Nasreen A.; Wong, Jan H.

doi:10.1007/s10549-019-05353-2

Cited by 28 publications

(20 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Studies have shown that patient age is associated with specific mortality from breast cancer. 8 In patients <46 years (128 patients), only 18.75% (24/128) had malignant lesions, whereas in patients over 46 years (54 patients), 72.22% (39/54) had malignant lesions. Therefore, it is feasible to consider age as a diagnostic marker for solid breast lesions in clinical practice.…”

Section: Discussionmentioning

confidence: 96%

Value of quantitative sound touch elastography of tissues around breast lesions in the evaluation of malignancy

et al. 2021

View full text Add to dashboard Cite

To assess the value of quantitative analysis of sound touch elastography of tissues around breast lesions to facilitate the evaluation of malignancy of the lesions. MATERIALS AND METHODS: With the permission of the Ethics Committee, every patient signed informed consent forms before the study. One hundred and eighty-two solid breast lesions were analysed retrospectively. Postoperative histopathology proved that 63 lesions were malignant and 119 were benign. All lesions were examined by two-dimensional ultrasonography, colour Doppler ultrasonography and ultrasound elastography including sound touch elastography (STE) and strain elastography. Using pathological diagnosis as the reference, the correlation between each ultrasound marker and the malignancy of the solid breast masses was evaluated by chi-square test, and the logistic regression model was constructed to determine the best diagnostic model with multiple markers. RESULTS: The areas under the receiver operating characteristic (ROC) curve (AUCs) of various elastography markers were compared and the markers with the largest AUC values, including quantitative, semi-quantitative, and distance markers were identified. Logistic regression analysis showed that the combination of accuracy of Breast Imaging Reporting and Data System (BI-RADS) classification þ age þ maximum elasticity value of the tissue around the lesion (EMax_shell) in predicting malignant lesions was higher than that of the other combinations. The prediction model verified that the sensitivity of diagnosis of the mammary lump was 94.12% and the specificity was 84.13%. CONCLUSIONS: EMax_shell in the elasticity is the most valuable marker for the diagnosis of breast cancer, and age combined with EMax_shell can effectively improve the diagnostic efficacy of the BI-RADS classification in breast cancer.

show abstract

Section: Discussionmentioning

confidence: 96%

Value of quantitative sound touch elastography of tissues around breast lesions in the evaluation of malignancy

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Previous analyses have found a quadratic relationship between age at diagnosis and BCSM in different subsets (19,20). Johnson et al (19) proposed a quadratic relationship between age and the risk of BCSM. Liu et al (20) proposed a U-shaped relationship between age and the risk of BCSM in the hormone receptor-positive subgroup, which was consistent with our result.…”

Section: Discussionmentioning

confidence: 99%

“…Younger age at diagnosis has been reported to be a factor for poor prognosis and is associated with more aggressive disease (17,18). Previous analyses have found a quadratic relationship between age at diagnosis and BCSM in different subsets (19,20). Johnson et al (19) proposed a quadratic relationship between age and the risk of BCSM.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Prognostic Impact of Age at Diagnosis Upon Breast Cancer of Different Immunohistochemical Subtypes: A Surveillance, Epidemiology, and End Results (SEER) Population-Based Analysis

et al. 2020

View full text Add to dashboard Cite

Background and Objectives: The influence of age at diagnosis of breast cancer upon the prognosis of patients with different immunohistochemical (IHC)-defined subtypes is still incompletely defined. Our study aimed at examining the association of age at diagnosis and risk of breast cancer-specific mortality (BCSM). Methods: 172,179 eligible breast cancer patients were obtained for our study cohort using the Surveillance, Epidemiology, and End Results database from 2010 to 2015. Patients were classified into four IHC-defined subtypes according to their ER, PgR, and HER2 status. Kaplan-Meier plots were used to describe BCSM among patients in different age groups. A Cox proportional hazards model was used for multivariate analysis. A multivariable fractional polynomial model within the Cox proportional hazards model was used to evaluate the relationship between age at diagnosis and the risk of BCSM. Results: For the whole cohort, the median follow-up time was 43 months. Patients younger than 40 years and those older than 79 years presented with the worst BCSM (hazard ratio [HR] 1.13, 95% confidence interval [CI] 1.03-1.23, and HR 3.52, 95% CI 3.23-3.83, respectively, p < 0.01, with age 40-49 years as the reference). The log hazard ratios of hormone receptor (HoR)(+)/HER2(-) patients formed a quadratic relationship between age at diagnosis and BCSM, but not in the other three subtypes of breast cancer. In the HoR(+)/HER2(-) subtype, patients younger than 40 years had worse BCSM than those aged at 40-49 years (HR 1.26, 95% CI 1.10-1.45, and p < 0.01). Conclusions: Women diagnosed with HoR(+)/HER2(-) breast cancer younger than 40 years or older than 79 years of age suffer higher rates of cancer-specific mortality. Young age at diagnosis may be particularly prognostic in HoR(+)/HER2(-) breast cancer.

show abstract

“…Outro estudo observou uma média de idade 47.7 anos 45 . Uma coorte encontrou uma média de idade de 59.7±13.8 46 . Outra coorte achou uma média de idade de 54.9 ±11.88 47 .…”

Section: Discussionunclassified

Preservação Da Fertilidade: Técnicas Com Bons Resultados Em Mulheres Com Câncer De Mama Hormônio Dependente Em Idade Fértil

Câmara¹,

Machado²,

Oliveira³

2021

Serviços E Cuidados Em Saúde 2

View full text Add to dashboard Cite

Direitos para esta edição cedidos à Atena Editora pelos autores. Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição-Não-Comercial-NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0).O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais. Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação com base em critérios de neutralidade e imparcialidade acadêmica.A Atena Editora é comprometida em garantir a integridade editorial em todas as etapas do processo de publicação, evitando plágio, dados ou resultados fraudulentos e impedindo que interesses financeiros comprometam os padrões éticos da publicação. Situações suspeitas de má conduta científica serão investigadas sob o mais alto padrão de rigor acadêmico e ético.

show abstract

Quantifying the relationship between age at diagnosis and breast cancer-specific mortality

Cited by 28 publications

References 43 publications

Value of quantitative sound touch elastography of tissues around breast lesions in the evaluation of malignancy

Value of quantitative sound touch elastography of tissues around breast lesions in the evaluation of malignancy

The Prognostic Impact of Age at Diagnosis Upon Breast Cancer of Different Immunohistochemical Subtypes: A Surveillance, Epidemiology, and End Results (SEER) Population-Based Analysis

Preservação Da Fertilidade: Técnicas Com Bons Resultados Em Mulheres Com Câncer De Mama Hormônio Dependente Em Idade Fértil

Contact Info

Product

Resources

About