“…The variables in mixture experiments are not independent; that is, changing one variable influences at least one other variable. Thus, the sum of all the proportions of the mixture components should be unity Equations (1) and (2) (Chen, Zhang, Gong, & Liang, ): where x i is the mixture proportion for ingredient i , and q is the number of ingredients. According to Liu, Li, Weng, Wong, and Tan (), a delimited subregion of interest in the mixture design of experiments is constructed by placing restrictions on the mixture component proportions.…”