Quantifying the Effect of Sex and Neuroanatomical Biomechanical Features on Brain Deformation Response in Finite Element Brain Models

Annals of Biomedical Engineering 2022 Year in Review

“…Subject-specific finite element brain models were developed from MRIs of both males and females and a head impact loading condition was simulated for an automotive impact case. The results showed that brain deformation during impact was not significantly influenced by sex-specific neuroanatomical differences; however, intracranial volumes had the largest effect on the brain deformation metrics and should be accounted for in future statistical models [16]. Finite element modeling remains a powerful tool to assess the influence of biomechanics on injury risk where innovative research efforts are focused on continued optimization of these models to incorporate sex and subject-specific differences.…”