Quantifying the dielectrophoretic force on colloidal particles in microfluidic devices

Abedini-Nassab, Roozbeh; Wirfel, Jake; Talebjedi, Bahram; Tasnim, Nishat; Hoorfar, Mina

doi:10.1007/s10404-022-02544-0

Cited by 13 publications

(4 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Microfluidic chips enhanced with active particle manipulation methods use at least one force other than hydrodynamic forces to manipulate cells. Methods based on magnetic [29][30][31][32][33][34], electric [35][36][37][38], acoustic [39][40][41][42][43], and optical forces [44][45][46][47][48], each of which, with their advantages and disadvantages, have been developed. In general, the active methods are rather more complicated than the passive methods; however, they typically offer more precise control of individual cells.…”

Section: Active Cell Manipulation Microfluidicsmentioning

confidence: 99%

Single-Cell RNA Sequencing in Organ and Cell Transplantation

Abedini-Nassab,

Taheri,

Emamgholizadeh

et al. 2024

Biosensors

Self Cite

View full text Add to dashboard Cite

Single-cell RNA sequencing is a high-throughput novel method that provides transcriptional profiling of individual cells within biological samples. This method typically uses microfluidics systems to uncover the complex intercellular communication networks and biological pathways buried within highly heterogeneous cell populations in tissues. One important application of this technology sits in the fields of organ and stem cell transplantation, where complications such as graft rejection and other post-transplantation life-threatening issues may occur. In this review, we first focus on research in which single-cell RNA sequencing is used to study the transcriptional profile of transplanted tissues. This technology enables the analysis of the donor and recipient cells and identifies cell types and states associated with transplant complications and pathologies. We also review the use of single-cell RNA sequencing in stem cell implantation. This method enables studying the heterogeneity of normal and pathological stem cells and the heterogeneity in cell populations. With their remarkably rapid pace, the single-cell RNA sequencing methodologies will potentially result in breakthroughs in clinical transplantation in the coming years.

show abstract

Section: Active Cell Manipulation Microfluidicsmentioning

confidence: 99%

Single-Cell RNA Sequencing in Organ and Cell Transplantation

Abedini-Nassab,

Taheri,

Emamgholizadeh

et al. 2024

Biosensors

Self Cite

View full text Add to dashboard Cite

show abstract

“…Therefore, there is a need for real-time on-site biosensors to detect antibiotics in dairy milk. Such real-time and on-site requirements can be realized through microfluidic devices 8,9,10 .…”

Section: Introductionmentioning

confidence: 99%

A lock-in amplifier biosensor for dairy applications

Devasagayam,

Leclerc,

Richardson

et al. 2023

Organic and Hybrid Sensors and Bioelectronics XVI

View full text Add to dashboard Cite

Antibiotic exposure can cause the development of antibiotic resistant bacteria and can induce allergic reactions in humans. A source of high antibiotic exposure is contaminated dairy milk. To prevent contaminated dairy milk, development of antibiotic biosensors for on-site detection is required. This is particularly important for dairy farmers as fines and suspension of license are consequences of shipping contaminated milk to processing plants, where antibiotic tests are currently performed. There are also environmental and economic consequences when whole dairy tanks are contaminated and go to waste. Our work addresses this problem by developing an antibiotic biosensor for farmers to test their milk onsite for ciprofloxacin prior to sending to processing plants. Ciprofloxacin is frequently used to treat common bacterial infections in cattle. Our work provides the following contributions. We introduce an antibiotic biosensor that integrates fluorescence spectroscopy, microfluidic processing, and lock-in amplification to improve the limit-of-detection of ciprofloxacin below the regulatory limit for milk. We also perform traditional fluorescence detection for comparison. Our antibiotic biosensor has a signal-flow starting with an ultraviolet light emitting diode for illumination of ciprofloxacin, and moving through a microfluidic platform, a photodiode for detection of the fluorescent wavelength, and a lock-in amplifier. Our antibiotic biosensor is well-suited for fast on-site analyses and is designed for ease-of-use. Overall, our work shows promise for the integration of real-time on-site antibiotic detection of antibiotics in dairy.

show abstract

“…Depending on the approach for generating the non-uniform electric field, DEP technology can be further categorized into electrode DEP (eDEP) and insulator-based DEP (iDEP) [19]. With the rapid progress of micro-and nanofabrication, several types of electrodes have been designed, such as quadrupole electrodes [20], interdigitated electrodes [21], virtual electrodes [22] and liquid-metal based electrodes [23], contributing to the successful application of the eDEP technique in diverse microfluidic and nanofluidic fields [24]. On the other hand, iDEP relies on the existence of insulated obstacles in the aqueous solution system to generate a non-uniform electric field under the DC voltage signal, giving it the advantages of simple fabrication and high cost-effectiveness [25].…”

Section: Introductionmentioning

confidence: 99%

Nanopore-based electrokinetic purification of oil-in-water emulsions with temperature and pH modulation

Zeng

et al. 2023

J. Phys. D: Appl. Phys.

View full text Add to dashboard Cite

Efficient purification of oil-in-water emulsion is significant for protecting global water resource. Nevertheless, the traditional passive technologies for handling oil-in-water emulsion suffer from the drawback of low cost-effectiveness for using robust filtration membranes. In our previous research, an active electrokinetic based oil droplet filtration technique is firstly developed relying on a negative dielectrophoretic phenomenon induced by the huge difference between dielectric properties of oil and water. However, the effects of temperature and pH value of wastewater on the electrokinetic filtration efficiency of oil droplet have never been clarified. In the current work, a multi-physical theoretical model of electrokinetic purification of oil-in-water emulsion with thermal and pH modulation is constructed. The dimensionless ratio of dielectrophoretic force over hydrodynamic force on oil droplet is an essential criterion for its dynamic behavior, and it exhibits a positive correlation with purification effectiveness of oil-in-water emulsion. From numerical modelling, the magnitude of dielectrophoretic force to hydrodynamic force ratio on oil droplet is enhanced with a decreasing temperature, increasing ion concentration, and neutralized (pH=7.0) property of oily wastewater. Then, the critical direct current voltage for realizing successful oil droplet filtration through insulated nanopore under electrokinetics is analyzed under different parametric conditions, which indicates that the energy consumption of oil-in-water emulsion purification can be reduced by cooling down temperature and neutralizing pH value of aqueous solution. The current work offers a theoretical understanding of electrokinetic purification of oil-in-water emulsion, contributing to its development towards industrial applications.

show abstract

Quantifying the dielectrophoretic force on colloidal particles in microfluidic devices

Cited by 13 publications

References 57 publications

Single-Cell RNA Sequencing in Organ and Cell Transplantation

Single-Cell RNA Sequencing in Organ and Cell Transplantation

A lock-in amplifier biosensor for dairy applications

Nanopore-based electrokinetic purification of oil-in-water emulsions with temperature and pH modulation

Contact Info

Product

Resources

About