Quantifying statistics of gene product copy-number fluctuations: A stochastic hybrid systems approach
Zahra Vahdat,
Abhyudai Singh
Abstract:Across diverse cell types, genes are often expressed at low levels resulting in significant stochastic fluctuations (noise) in intracellular copy number of mRNAs and proteins over time. Motivated by single-cell experiments, we capture this stochasticity by considering a given gene that toggles between a transcriptionally active and inactive state with the time spent in each state being an arbitrary random variable. mRNAs are synthesized from the active state as per a Poisson process and each molecule degrades… Show more
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