Quantifying Poststroke Apathy With Actimeters

Goldfine, Andrew M.; Dehbandi, Behdad; Kennedy, Juliana; Sabot, Briana; Semper, Cory; Putrino, David

doi:10.1176/appi.neuropsych.15090235

Cited by 5 publications

(2 citation statements)

References 24 publications

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“…Apathy is usually proxy-assessed through the SAS[ 40 ], the Apathy Evaluation Scale[ 123 ], the Apathy Inventory-Clinical Scale[ 122 ] or the Dimensional Apathy Scale[ 124 ] in addition to the NPI[ 24 ]. Actigraphy records from an unaffected arm may serve to measure poststroke apathy in PWA, but should not be used alone[ 125 ]. Crucial brain structures for motivated behavior in healthy people include fronto-striatal circuits (including the nucleus accumbens), the dorsal anterior cingulate and the orbitofrontal cortex[ 126 , 127 ].…”

Section: Resultsmentioning

confidence: 99%

Spectrum of neuropsychiatric symptoms in chronic post-stroke aphasia

Edelkraut¹,

López-Barroso²,

Torres‐Prioris³

et al. 2022

WJP

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BACKGROUND Neuropsychiatric symptoms (NPS) have been insufficiently examined in persons with aphasia (PWA) because most previous studies exclude participants with language and communication disorders. AIM To report a two-part study consisting of a literature review and an observational study on NPS in post-stroke aphasia. METHODS Study 1 reviewed articles obtained from PubMed, PsycINFO, Google Scholar and Cochrane databases after cross-referencing key words of post-stroke aphasia to NPS and disorders. Study 2 examined language deficits and activities of daily living in 20 PWA (median age: 58, range: 28-65 years; 13 men) with the Western Aphasia Battery-Revised and the Barthel Index, respectively. Informants of these 20 PWA were proxy-evaluated with the Neuropsychiatric Inventory and domain-specific scales, including the Stroke Aphasia Depression Questionnaire-10 item version and the Starkstein Apathy Scale. In addition, an adapted version of the Hospital Anxiety and Depression Scale was directly administered to the PWA themselves. This observational study is based on the baseline assessment of an intervention clinical trial (EudraCT: 2017-002858-36; ClinicalTrials.gov identifier: NCT04134416). RESULTS The literature review revealed a broad spectrum of NPS in PWA, including depression, anxiety, apathy, agitation/aggression, eating and sleep disorders, psychosis, and hypomania/mania. These findings alert to the need for improving assessment and treatment approaches of NPS taking into consideration their frequent occurrence in PWA. Study 2 showed that the 20 participants had mild- to-moderate aphasia severity and were functionally independent. A wide range of comorbid NPS was found in the post-stroke aphasic population (median number of NPS: 5, range: 1-8). The majority of PWA (75%) had depressive symptoms, followed by agitation/aggression (70%), irritability (70%), anxiety (65%) and appetite/eating symptoms (65%). Half of them also presented symptoms of apathy, whereas euphoria and psychotic symptoms were rare (5%). Domain-specific scales revealed that 45% of participants had apathy and 30% were diagnosed with depression and anxiety. CONCLUSION Concurrent NPS are frequent in the chronic period of post-stroke aphasia. Therefore, further research on reliable and valid assessment tools and treatment for this aphasic population is strongly warranted.

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Section: Resultsmentioning

confidence: 99%

Spectrum of neuropsychiatric symptoms in chronic post-stroke aphasia

Edelkraut¹,

López-Barroso²,

Torres‐Prioris³

et al. 2022

WJP

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“…Gaming and overall enjoyment from participating in that research program served as modulators for improved outcomes [3]. Apathy toward the program correlated with poorer outcomes [4].…”

Section: Session 1: Thementioning

confidence: 99%

LiveWell RERC State of the Science Conference Report on ICT Access to Support Community Living, Health and Function for People with Disabilities

Morris

Jones

DeRuyter

et al. 2019

IJERPH

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This article summarizes the proceedings of the three session State of the Science (SOS) Conference that was conducted by the Rehabilitation Engineering Research Center for Community Living, Health and Function (LiveWell RERC) in June 2019 in Toronto, Canada. RERCs customarily convene an SOS conference toward the end of their five-year funding cycle in order to assess the current state and identify potential future research, development, and knowledge translation efforts needed to advance their field. The first two sessions focused on the current and future state of information and communication technology (ICT) for mobile health (mHealth) and mobile rehabilitation (mRehab). The third session was a wide-ranging discussion of pressing needs for future research and development in the field. Several “big ideas” resulted from the discussion among participants in the SOS Conference that should inform the structure and operation of future efforts, including: (1) identifying active ingredients of interventions, (2) incorporating effective behavior-change techniques into all interventions, (3) including measures of social determinants of health in evaluation studies, (4) incorporating user-customizable features into technology solutions, and (5) ensuring “discoverability” of research and development outputs by stakeholders via structured and continuous outreach, education and training. Substantive areas of work include gaming and esports, the gamification of interventions for health and fitness, the cultivation of community supports, and continuous outreach and education wherever a person with a disability may live.

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Intraneuronal accumulation of C99 contributes to synaptic alterations, apathy-like behavior, and spatial learning deficits in 3×TgAD and 2×TgAD mice

Bourgeois

Lauritzen

Lorivel

et al. 2018

Neurobiology of Aging

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The triple transgenic mouse model (3×TgAD: APPswe, Tau, PS1) recapitulates both amyloid β (Aβ)- and tau-related lesions as well as synaptic and memory deficits. In these mice, we reported an early apathy-like behavior and alterations in synaptic plasticity appearing concomitantly with intraneuronal accumulation of C99 in the subiculum. To delineate the genuine contribution of C99 on the above phenotypes, we generated double transgenic mice (2×TgAD: APPswe, Tau) that accumulate C99 without Aβ deposition or hyperphosphorylation of tau and compared them to 3×TgAD mice. Here, we show that both TgAD mice display similar decreases in long-term potentiation and in spontaneous locomotor activity measured by actimetry suggesting that the synaptic alterations and the apathy-like behavior were likely linked to C99 rather than Aβ. However, spatial learning alterations, assessed by the Morris water maze task, are more pronounced in 3×TgAD than in 2×TgAD, suggesting that both Aβ and C99 contribute to defects in the acquisition of spatial information. Finally, even if similar results are observed in males, cognitive and non-cognitive deficits are more severe in females.

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Quantifying Poststroke Apathy With Actimeters

Cited by 5 publications

References 24 publications

Spectrum of neuropsychiatric symptoms in chronic post-stroke aphasia

Spectrum of neuropsychiatric symptoms in chronic post-stroke aphasia

LiveWell RERC State of the Science Conference Report on ICT Access to Support Community Living, Health and Function for People with Disabilities

Intraneuronal accumulation of C99 contributes to synaptic alterations, apathy-like behavior, and spatial learning deficits in 3×TgAD and 2×TgAD mice

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