Quantifying optical properties with visible and near-infrared optical coherence tomography to visualize esophageal microwave ablation zones

Niemeier, Ryan C.; Etoz, Sevde; Gil, Daniel A.; Skala, Melissa C.; Brace, Christopher L.; Rogers, Jeremy D.

doi:10.1364/boe.9.001648

Cited by 5 publications

(2 citation statements)

References 41 publications

(57 reference statements)

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“…At the beginning of laser exposure, laser beam irradiation results in the formation of blisters that later collapse. In previous studies, it was demonstrated that the tissue temperature was proportional to the exposure time and that the scattering coefficient increased with temperature [36], [37]. As shown in Fig.…”

Section: Discussionmentioning

confidence: 77%

Optical Coherence Tomography/Angiography-Guided Tumor Ablation With a Continuous-Wave Laser Diode

et al. 2020

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Laser ablation can be an effective modality for treatment, but it is complicated to apply continuous-wave (CW) light sources for laser ablation because of the unpredictable photothermal damage. In this study, an integrated theranostic system combining a low-cost CW laser diode with optical coherence tomography (OCT)/angiography (OCTA) was utilized for the in vivo ablation of tumor tissues. To examine the effect of laser exposure on tissue scattering characteristics, the OCT backscattering intensities of nonablated and ablated tissues were analyzed, and the effect on the skin microvasculature produced by laser ablation was quantitatively evaluated. Moreover, the integrated system and the proposed method were implemented for the treatment of skin tumor on the mouse model. The obtained results indicate that the developed laser ablation system can effectively remove tumor tissues with controllable photodamage under OCT/OCTA guidance and that the system cost may be significantly reduced by using the CW laser diode.

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Section: Discussionmentioning

confidence: 77%

Optical Coherence Tomography/Angiography-Guided Tumor Ablation With a Continuous-Wave Laser Diode

et al. 2020

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“…There is a growing interest in producing and utilizing 3D maps of the attenuation coefficient [21,32]. For example, depth-resolved attenuation coefficient maps have already been employed to investigate various tissues, including atheroscletertic [33], brain [20], and esophageal [34]. These depth-resolved methods are still vulnerable to the limitations discussed previously, namely the restriction to low-NA lenses and difficulty in precisely specifying the position of focus.…”

Section: Discussionmentioning

confidence: 99%

Determination of confocal profile and curved focal plane for OCT mapping of the attenuation coefficient

Ştefan¹,

Jeong²,

Polucha³

et al. 2018

Biomed. Opt. Express

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The attenuation coefficient has proven to be a useful tool in numerous biological applications, but accurate calculation is dependent on the characterization of the confocal effect. This study presents a method to precisely determine the confocal effect and its focal plane within a sample by examining the ratio of two optical coherence tomography (OCT) images. The method can be employed to produce a single-value estimate, or a 2D map of the focal plane accounting for the curvature or tilt within the sample. Furthermore, this method is applicable to data obtained with both high numerical aperture (NA) and low-NA lenses, thereby furthering the applicability of the attenuation coefficient to high-NA OCT data. We test and validate this method using standard samples of Intralipid 20% and 5%, improving the accuracy to 99% from 65% compared to the traditional method and preliminarily show applicability to real biological data of glioblastoma acquired in vivo in a murine model.

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Optical‐resolution photoacoustic microelastography system for elasticity mapping: Phantom study and practical application

Wan,

Zhang,

et al. 2024

Journal of Biophotonics

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Elastography is a noninvasive technique for characterizing the mechanical properties of biological tissues. Conventional methods have limitations in resolution and sensitivity, hindering disease detection in clinical diagnostics. To address these issues, this study developed an optical‐resolution photoacoustic microelastography (OR‐PAME) system. Using an agar tissue phantom with varying agar concentrations and contrast agents, PAME evaluated elasticity distribution under compression in both lateral and axial dimensions. It indirectly measured elastic properties by correlating photoacoustic responses, temporal lags, and induced displacement. We also applied the system to the study of the distribution of elastic characteristics of the liver tissue after ablation, which confirmed the potential of OR‐PAME in the study of elastic characteristics. Quantitative analysis showed greater lateral displacement in regions with reduced agar concentrations, indicating decreased stiffness. PAME also detected vertical displacement along the axial plane, validating its efficacy in elastographic imaging. By improving resolution and penetration, PAME provides superior visualization of elasticity distribution. Its methodology correlates microstructural alterations with tissue biomechanics, holding potential implications in medical diagnostics.

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Quantifying optical properties with visible and near-infrared optical coherence tomography to visualize esophageal microwave ablation zones

Cited by 5 publications

References 41 publications

Optical Coherence Tomography/Angiography-Guided Tumor Ablation With a Continuous-Wave Laser Diode

Optical Coherence Tomography/Angiography-Guided Tumor Ablation With a Continuous-Wave Laser Diode

Determination of confocal profile and curved focal plane for OCT mapping of the attenuation coefficient

Optical‐resolution photoacoustic microelastography system for elasticity mapping: Phantom study and practical application

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