Quantifying Non‐Covalent Binding Interactions between Tobacco Alkaloids and Cyclodextrin Using Mass Spectrometry and the Application in Cigarette Smoke
Abstract:The host-guest inclusion complexes between cyclodextrin (CD) and five tobacco alkaloids (TAs), namely 1-(4-Nitrophenyl) piperazine (NHK), nicotinamide (NAm), nornicotine (NCt), DL-Anabasine (DL-ABs), and nicotinic acid (NTa), were explored via electrospray ionization mass spectrometry (ESI-MS). The MS results of these CD complexes confirmed the 1 : 1 stoichiometry of the host-guest assemblies formed. The binding constants of the complexes were studied to quantify the interactions between TAs and CDs. The bindi… Show more
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