Quantifying Low Birth Weight, Preterm Birth and Small-for-Gestational-Age Effects of Malaria in Pregnancy: A Population Cohort Study

Rijken, Marcus J.; Livera, Alysha M De; Lee, Sue J.; Boel, Machteld E.; Rungwilailaekhiri, Suthatsana; Wiladphaingern, Jacher; Paw, Moo Kho; Pimanpanarak, Mupawjay; Pukrittayakamee, Sasithon; Simpson, Julie A; Nosten, François; McGready, Rose

doi:10.1371/journal.pone.0100247

Cited by 45 publications

(36 citation statements)

References 30 publications

(45 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…If rickettsial infection does not result in miscarriage the outcomes for the neonate are not encouraging. In the SMRU fever cohort where population data collected during the same period is available, typhus appeared to result in a higher proportion of preterm birth (14.3%) and birth weight below the 10 th centile (22.2%) than reported for malaria during pregnancy (7.3% (58/794) and 17.0% (88/519) respectively) [33] .…”

Section: Discussionmentioning

confidence: 92%

“…Infants born at home and not weighed on the day of birth had their weight adjusted as described for this population [32] . Poor neonatal outcome was a composite measure for women whose pregnancy was sustained to 28 weeks or more of gestation and included stillbirth, prematurity and fetal growth restriction defined as a birth weight for gestational age of <10 th centile for the population [33] .…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Pregnancy Outcome in Relation to Treatment of Murine Typhus and Scrub Typhus Infection: A Fever Cohort and a Case Series Analysis

et al. 2014

Self Cite

View full text Add to dashboard Cite

BackgroundThere is a paucity of published reports on pregnancy outcome following scrub and murine typhus despite these infections being leading causes of undifferentiated fever in Asia. This study aimed to relate pregnancy outcome with treatment of typhus.Methodology/Principal FindingsData were analyzed from: i) pregnant women with a diagnosis of scrub and/or murine typhus from a fever cohort studies; ii) case series of published studies in PubMed using the search terms “scrub typhus” (ST), “murine typhus” (MT), “Orientia tsutsugamushi”, “Rickettsia tsutsugamushi”, “Rickettsia typhi”, “rickettsiae”, “typhus”, or “rickettsiosis”; and “pregnancy”, until February 2014 and iii) an unpublished case series. Fever clearance time (FCT) and pregnancy outcome (miscarriage and delivery) were compared to treatment. Poor neonatal outcome was a composite measure for pregnancies sustained to 28 weeks or more of gestation ending in stillbirth, preterm birth, or delivery of a growth restricted or low birth weight newborn.ResultsThere were 26 women in the fever cohort. MT and ST were clinically indistinguishable apart from two ST patients with eschars. FCTs (median [range] hours) were 25 [16–42] for azithromycin (n = 5), 34 [20–53] for antimalarials (n = 5) and 92 [6–260] for other antibiotics/supportive therapy (n = 16). There were 36.4% (8/22) with a poor neonatal outcome.In 18 years, 97 pregnancies were collated, 82 with known outcomes, including two maternal deaths. Proportions of miscarriage 17.3% (14/81) and poor neonatal outcomes 41.8% (28/67) were high, increasing with longer FCTs (p = 0.050, linear trend). Use of azithromycin was not significantly associated with improved neonatal outcomes (p = 0.610)ConclusionThe published ST and MT world literature amounts to less than 100 pregnancies due to under recognition and under diagnosis. Evidence supporting the most commonly used treatment, azithromycin, is weak. Collaborative, prospective clinical trials in pregnant women are urgently required to reduce the burden of adverse maternal and newborn outcomes and to determine the safety and efficacy of antimicrobial treatment.

show abstract

Section: Discussionmentioning

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Pregnancy Outcome in Relation to Treatment of Murine Typhus and Scrub Typhus Infection: A Fever Cohort and a Case Series Analysis

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…Ultrasound was introduced in 2001 using Dynamic Imaging, Fukuda Denshi UF 4100 (since 2002) and Toshiba Powervision 7000 machine (Toshiba, Tokyo, Japan since 2006), all with a 3•75-MHz convex probe, with all women routinely offered two scans. The booking visit scan (between 8 and 14 weeks' gestation) calculates estimated gestational age (EGA) by crown-rump length measurement using the British ultrasound guidelines and with regular quality control in place (36,37) . Labour and delivery wards were established in Wang Pha in 2008 and Maw Ker Thai in 2010.…”

Section: A Brief History Of the Shoklo Malaria Research Unit And Popumentioning

confidence: 99%

Nutrition in transition: historical cohort analysis summarising trends in under- and over-nutrition among pregnant women in a marginalised population along the Thailand–Myanmar border from 1986 to 2016

Hashmi

Lee

et al. 2019

Br J Nutr

Self Cite

View full text Add to dashboard Cite

The objective of the present study is to summarise trends in under- and over-nutrition in pregnant women on the Thailand–Myanmar border. Refugees contributed data from 1986 to 2016 and migrants from 1999 to 2016 for weight at first antenatal consultation. BMI and gestational weight gain (GWG) data were available during 2004–2016 when height was routinely measured. Risk factors for low and high BMI were analysed for <18·5 kg/m2 or ≥23 kg/m2, respectively. A total of 48 062 pregnancies over 30 years were available for weight analysis and 14 646 pregnancies over 13 years (2004–2016) had BMI measured in first trimester (<14 weeks’ gestational age). Mean weight at first antenatal consultation in any trimester increased over the 30-year period by 2·0 to 5·2 kg for all women. First trimester BMI has been increasing on average by 0·5 kg/m2 for refugees and 0·6 kg/m2 for migrants, every 5 years. The proportion of women with low BMI in the first trimester decreased from 16·7 to 12·7 % for refugees and 23·1 to 20·2 % for migrants, whereas high BMI increased markedly from 16·9 to 33·2 % for refugees and 12·3 to 28·4 % for migrants. Multivariate analysis demonstrated low BMI as positively associated with being Burman, Muslim, primigravid, having malaria during pregnancy and smoking, and negatively associated with refugee as opposed to migrant status. High BMI was positively associated with being Muslim and literate, and negatively associated with age, primigravida, malaria, anaemia and smoking. Mean GWG was 10·0 (sd 3·4), 9·5 (sd 3·6) and 8·3 (sd 4·3) kg, for low, normal and high WHO BMI categories for Asians, respectively.

show abstract

“…According to the Ghana Multiple Indicator Cluster Survey (MICS) conducted in 2011, 3.5 million cases of clinical malaria are estimated to be reported each year in public health facilities, accounting for 38% of outpatient attendance and 35% of all admissions and 34% of deaths in children below five years of age [6]. The main effects of MiP include low birth weight, premature birth, anaemia, and mortality of the newborns [1, 7–9]. …”

Section: Introductionmentioning

confidence: 99%

Low Utilization of Insecticide-Treated Bed Net among Pregnant Women in the Middle Belt of Ghana

Manu

Boamah-Kaali

Febir

et al. 2017

Malaria Research and Treatment

View full text Add to dashboard Cite

Background Malaria in pregnancy leads to low birth weight, premature birth, anaemia, and maternal and neonatal mortality. Use of insecticide-treated nets (ITNs) during pregnancy is one of the proven interventions to reduce the malaria burden. However, Ghana has not achieved its target for ITN use among pregnant women. Methods A qualitative study was conducted in seven communities purposively selected from the middle belt of Ghana. Participants who had delivered in the six months prior to this study were selected. In all, seven focus group discussions and twenty-four in-depth interviews were conducted between June and August 2010. Results Respondents knew of the importance of ITNs and other malaria-preventive strategies. Factors such as financial access and missed opportunities of free distribution denied some pregnant women the opportunity to own or use an ITN. Reasons for not using ITNs during pregnancy included discomfort resulting from heat, smell of the net, and difficulty in hanging the net. Participants maintained their ITNs by preventing holes in the nets, retreatment, and infrequent washing. Conclusion Pregnant women know about the causes and prevention of malaria. However, this knowledge is not transformed into practice due to lack of access to ITNs and sleeping discomforts among other logistical constraints.

show abstract

Quantifying Low Birth Weight, Preterm Birth and Small-for-Gestational-Age Effects of Malaria in Pregnancy: A Population Cohort Study

Cited by 45 publications

References 30 publications

Pregnancy Outcome in Relation to Treatment of Murine Typhus and Scrub Typhus Infection: A Fever Cohort and a Case Series Analysis

Pregnancy Outcome in Relation to Treatment of Murine Typhus and Scrub Typhus Infection: A Fever Cohort and a Case Series Analysis

Nutrition in transition: historical cohort analysis summarising trends in under- and over-nutrition among pregnant women in a marginalised population along the Thailand–Myanmar border from 1986 to 2016

Low Utilization of Insecticide-Treated Bed Net among Pregnant Women in the Middle Belt of Ghana

Contact Info

Product

Resources

About