Quantifying in vivo collagen reorganization during immunotherapy in murine melanoma with second harmonic generation imaging
Alexa R. Heaton,
Nathaniel J. Burkard,
Paul M. Sondel
et al.
Abstract:Significance:
Increased collagen linearization and deposition during tumorigenesis can impede immune cell infiltration and lead to tumor metastasis. Although melanoma is well studied in immunotherapy research, studies that quantify collagen changes during melanoma progression and treatment are lacking.
Aim:
We aim to image
in vivo
collagen in preclinical melanoma models during immunotherapy and quantify the collagen phenotype in treated and co… Show more
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