Quantifying how drug-polymer interaction and volume phase transition modulate the drug release kinetics from core-shell microgels

Lim, Poh Teck; Irwan, Risky Muhamad; Li, Zhong; Goh, K.B.

doi:10.1016/j.ijpharm.2022.121838

Cited by 12 publications

(2 citation statements)

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“…Furthermore, at pH 7, 10, and 11, the κC-Sa/ZnO biopolymer was less soluble, resulting in low permeability, a higher water content, as well as a higher permeability of HCQ (Fahmy et al 2021;Sethi et al 2022). Figure 10D shows the effect of the different concentrations of salts on the release of the drug on the surface of the polymer, as it was found that the highest point of release was at a salt concentration (0.1g NaCl) and the highest release rate was 54% within 8 hours (Lim et al 2022).…”

Section: Drug Loading In Vitromentioning

confidence: 97%

Drug Carriers in The Delivery and Release of Hydroxychloroquine by Biopolymer

Jasim

Al-Hussainawy

2023

Preprint

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The successful creation of several unique and intelligent drug delivery systems with improved therapeutic effectiveness, improved patient compliance, and new developments and research in the realm of biopolymers guides cost effectiveness. Several biodegradable polymers are widely employed in the drug delivery industry because they are biologically broken down inside the body into non-toxic components. The design of diverse drug delivery systems based on biopolymers can benefit from a comprehensive understanding of the possible qualities of biopolymers, including extraction techniques and environmentally friendly manufacturing, chemistry, surface properties, rheology, bulk properties, biocompatibility, and biodegradability. Accordingly, new biopolymers were synthesized by free radical and cross-linked molecules and their physical and chemical properties were studied, and some comprehensive examinations were conducted for the task of research, such as FT-IR-EDX, XRD, SEM, TEM, TGA, and BET-BJH. Good results were obtained for adsorption and releasing the adsorbed drug into the aqueous solution with a percentage of 20% at pH 2 and 3% at pH 7, 10. The divorce rate was high when there were different concentrations of salt.

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