Quantifying effects of radiotherapy-induced microvascular injury; review of established and emerging brain MRI techniques

J, Klos; Laar, Peter Jan van; Sinnige, Peter F.; Enting, Roelien H.; Kramer, Miranda C.A.; Weide, Hiske L van der; Buchem, Mark A. van; Dierckx, Rudi; Borra, Ronald; Hoorn, Anouk van der

doi:10.1016/j.radonc.2019.05.020

Cited by 30 publications

(27 citation statements)

References 154 publications

(240 reference statements)

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“…Radiation responses on molecular and cellular levels can result in anatomical and functional changes that can be visualised using MRI and PET based imaging [40,49]. Novel high-resolution techniques enable a more intricate and early evaluation of microstructural changes [50].…”

Section: Imagingmentioning

confidence: 99%

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Proton therapy for selected low grade glioma patients in the Netherlands

Weide

Kramer

Scandurra

et al. 2021

Radiotherapy and Oncology

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Section: Imagingmentioning

confidence: 99%

“…The grey matter and white matter display regional differences in radiation sensitivity [63][64][65]. Other anatomical changes that are seen after radiation include vasogenic brain oedema resulting from an increased blood-brain barrier permeability, and cerebral microbleeds due to structural damage to the microvasculature [50].…”

Section: Imagingmentioning

confidence: 99%

Proton therapy for selected low grade glioma patients in the Netherlands

Weide

Kramer

Scandurra

et al. 2021

Radiotherapy and Oncology

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“…47 The use and validation of both established and new techniques in the context of monitoring early and late brain damage induced by RT in the healthy tissues currently are minimal at best. 105,106 In this section, the performance and limitations of existing imaging techniques and the relation of these findings with key clinical parameters were summarized. Diffusion tensor imaging, as the most sensitive imaging technique, can visualize and evaluate WM integrity and histopathological alterations, distinguish infiltrative growing tumors from bounded tumors and properly specify the tumor grade with conventional magnetic resonance imaging (MRI).…”

Section: Biomarkers Of Radiation-induced Brain Damage Used In Imagingmentioning

confidence: 99%

Section: Biomarkersmentioning

confidence: 99%

Biomarkers of Brain Damage Induced by Radiotherapy

et al. 2020

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Radiotherapy remains currently a critical component for both primary and metastatic brain tumors either alone or in combination with surgery, chemotherapy, and molecularly targeted agents, while it could cause simultaneously normal brain tissue injury leading to serious health consequences, that is, development of cognitive impairments following cranial radiotherapy is considered as a critical clinical disadvantage especially for the whole brain radiotherapy. Biomarkers can help to detect the accurate physiology or conditions of patients with brain tumor and develop effective treatment procedures for these patients. In the near future, biomarkers will become one of the prime driving forces of cancer treatment. In this minireview, we analyze the documented work on the acute brain damage and late consequences induced by radiotherapy, identify the biomarkers, in particular, the predictive biomarkers for the damage, and summarize the biological significance of the biomarkers. It is expected that translation of these research advance to radiotherapy would assist stratifying patients for optimized treatment and improving therapeutic efficacy and the quality of life.

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“…Conventional magnetic resonance imaging (MRI) can identify some long-term changes of the CNS tissue, such as morphologic local damage, brain atrophy, and leukoencephalopathy, but these findings poorly correlate with the functional deterioration observed in these patients. 10 More recently, advanced MRI biomarkers reflecting microvascular integrity and function have been reported and might provide a more accurate and earlier detection of microstructural changes. 11 Diffusion tensor imaging (DTI) is one of these emerging MRI-based techniques that can detect and quantify specific white matter (WM) changes earlier than conventional MRI.…”

Section: Introductionmentioning

confidence: 99%

Possible association between the integrity of cerebellar pathways and neurocognitive performance in children with posterior fossa tumors

Liguoro

Passone

Zilli

et al. 2020

Pediatric Blood & Cancer

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Background Cerebellar tumor survivors often exhibit neuropsychological deficits that could be related to alterations in cerebro‐cerebellar networks. This is a pilot study designed to understand if diffusion tensor imaging (DTI)‐based tractography is able to identify possible correlations between cerebellar white matter structure and cognitive outcome in children on long‐term follow‐up for posterior fossa (PF) tumors who were thoroughly assessed for neuropsychological functioning. Methods DTI‐based tractography was performed in pediatric patients with PF tumors. Fractional anisotropy (FA) and volumetric measurements of spinocerebellar, dentorubrothalamocortical and corticopontocerebellar tracts were analyzed. Cognitive and neuropsychological functioning was assessed by the Wechsler Intelligence Scale for Children–IV Edition (WISC‐IV) and the Developmental Neuropsychological Assessment (NEPSY II). The associations between Full‐Scale Intelligence Quotient (FSIQ), NEPSY‐II scores, and fiber tracts were tested by the Spearman rank correlation coefficient. Results Seven patients (median age at diagnosis five years, range, 3‐13) treated for medulloblastoma (2/7; 29%) and pilocytic astrocytoma (5/7; 71%) were retrospectively evaluated. All children had complete surgery. The median FSIQ was 84 (range, 67‐93). Patients presented with several deficits on many NEPSY‐II tasks; in particular, memory was impaired in nearly half of them. FSIQ and neurocognitive tasks significantly correlated with specific corticopontocerebellar tracts. Conclusion Children on follow‐up for PF tumor showed scattered cognitive impairments, including deficits in long‐term and immediate memory. Tractography allowed us to describe a possible association between the integrity of cerebellar pathways and neurocognitive performance, suggesting that the myelinization of these fibers may represent an indicator for the development of long‐term cognitive sequelae.

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Quantifying effects of radiotherapy-induced microvascular injury; review of established and emerging brain MRI techniques

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Cited by 30 publications

References 154 publications

Proton therapy for selected low grade glioma patients in the Netherlands

Proton therapy for selected low grade glioma patients in the Netherlands

Biomarkers of Brain Damage Induced by Radiotherapy

Possible association between the integrity of cerebellar pathways and neurocognitive performance in children with posterior fossa tumors

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