Human actions compromise the many life-supporting functions of the global freshwater cycle. Yet, an encompassing analysis of humanity’s aggregate impact on the freshwater cycle is still missing. We compare the current state of the freshwater cycle against a stable reference state by estimating the global area experiencing streamflow and soil moisture deviations beyond pre-industrial variability range. We propose replacing the current freshwater use planetary boundary (PB) with our thus-defined freshwater change PB. Our analysis indicates unprecedented change: locally, the impacts of e.g. climate change, land use, and dams, are clearly visible. Globally, we find 70% and 44% increases in areas experiencing streamflow and soil moisture deviations. This suggests a transgression of the PB, calling for urgent actions to reduce human disturbance of the freshwater cycle.