Quantifying competitive advantages of mutant strains in a population involving importation and mass vaccination rollout

Xia, Fan; Yang, Xinpei; Cheke, Robert; Xiao, Yanni

doi:10.1016/j.idm.2021.08.001

Cited by 24 publications

(22 citation statements)

References 16 publications

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“…Some of reported studies were performed before detection of the Delta variant, which has a significantly higher transmission capacity than other strains and can be more easily spread by vaccinated individuals. In fact, this can explain the rebound of the virus in many countries, including the United Kingdom (UK), where the proportion of vaccinated individuals is high and some prevention and control measures are still in place [121].…”

Section: The Immunity and Virus Transmission After Vaccinationmentioning

confidence: 99%

What Happens to the Immune System after Vaccination or Recovery from COVID-19?

Tiyo

Schmitz

Ortega

et al. 2021

Life

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Due to its leading role in fighting infections, the human immune system has been the focus of many studies in the context of Coronavirus disease 2019 (COVID-19). In a worldwide effort, the scientific community has transitioned from reporting about the effects of the novel coronavirus on the human body in the early days of the pandemic to exploring the body’s many immunopathological and immunoprotecting properties that have improved disease treatment and enabled the development of vaccines. The aim of this review is to explain what happens to the immune system after recovery from COVID-19 and/or vaccination against SARS-CoV-2, the virus that causes the disease. We detail the way in which the immune system responds to a SARS-CoV-2 infection, including innate and adaptive measures. Then, we describe the role of vaccination, the main types of COVID-19 vaccines and how they protect us. Further, we explain the reason why immunity after COVID-19 infection plus a vaccination appears to induce a stronger response compared with virus exposure alone. Additionally, this review reports some correlates of protection from SARS-CoV-2 infection. In conclusion, we reinforce that vaccination is safe and important in achieving herd immunity.

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Section: The Immunity and Virus Transmission After Vaccinationmentioning

confidence: 99%

What Happens to the Immune System after Vaccination or Recovery from COVID-19?

Tiyo

Schmitz

Ortega

et al. 2021

Life

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“…Although the spread of COVID-19 in China has been controlled to a certain extent, the risk of being infected has not subsided ( 3 ). Moreover, the B.1.617.2 (delta) variant has delivered a huge shock even to countries that have been mass vaccinated, because of its higher load and faster spread than SARS-CoV-2 ( 4 ). Therefore, the first local case in May ( 5 ), 1 month after the previous outbreak, has caused a considerable degree of panic (such as anxiety) in China.…”

Section: Introductionmentioning

confidence: 99%

Resilience and Anxiety Among Healthcare Workers During the Spread of the SARS-CoV-2 Delta Variant: A Moderated Mediation Model

Liu

Hou

et al. 2022

Front. Psychiatry

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IntroductionThe B.1.617.2 (Delta) variant of SARS-COV-2 has caused a surge in COVID-19 cases worldwide, placing a great burden on the health care system under the zero-tolerance epidemic prevention policy in China. The present study aimed to investigate the prevalence of anxiety among health care workers during the spread of the SARS-CoV-2 Delta variant, and to discuss the mediating role of positive coping style between resilience and anxiety, and the moderating role of general self-efficacy.MethodConnor-Davidson Resilience scale (CD-RISC), Generalized Anxiety Disorder Scale (GAD-7), General Self-efficacy Scale (GSES) and Simplified Coping Style Questionnaire (SCSQ) were used in this cross-sectional study among 390 healthcare workers in Jiangsu Province, China. Mackinnon's four-step procedure was applied to test the mediation effect, and Hayes PROCESS macro was conducted to examine the moderated mediation model.ResultsThe prevalence of anxiety among Chinese healthcare workers during the spread of the SARS-CoV-2 Delta variant was 41.8%. Male, unmarried, childless and younger subjects reported higher levels of anxiety. Positive coping partially mediated the effect of resilience on anxiety among healthcare workers and the indirect effect was stronger with the increase of general self-efficacy.ConclusionsAnxiety was prevalent among healthcare workers during the spread of SARS-CoV-2 Delta variant. This research sheds new light on the potential mechanism underlying the association between resilience and anxiety and provides new insight into the prevention of anxiety among healthcare workers during the spread of the SARS-CoV-2 Delta variant.

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“…However, in the period July-August 2021 an increase of infections registered in Italy has been observed [35], probably due to the Delta variant, becoming the dominant variant in England by late May, due to partial immune escape [36]. In particular, a single dose vaccination is not sufficiently protective [37] and the Delta variant has a significantly higher transmission capacity than the Alpha variant [38].…”

Section: Discussionmentioning

confidence: 99%

Prevention Procedures to Contain COVID-19 Contagion in the First Italian Army Field Hospital

Ciccotti¹,

Pagliaro²,

Peluso³

et al. 2021

IJSSE

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The COVID-19 outbreak in Italy saturated the public hospitals' intensive care units in March 2020. The Ministry of Health asked for the Military Health Unit's intervention to deal with the emergency. The first COVID-19 Army field hospital in the world was thus built in Piacenza, Italy, to address the emergency. We describe the architecture of the hospital and the preventive measures adopted to reduce COVID-19 contagion among the medical personnel. The hospital project with the "H" shape divides the "dirty path" of entry for operators and patients from the "clean path" of exit for operators. Hypochloritebased and alcohol-based solutions were used for personal protective equipment (PPE) decontamination before reuse. Although exposed to 50 confirmed COVID-19 patients, all primary care personnel tested negative to COVID-19, before the operation, 14 days after the first patient and 30 days after the closure of the military field hospital. Due to the reported discomfort and its potential toxicity, the hypochlorite-based disinfection method was substituted with alcohol-based disinfection solution, which displayed comparable effective results. The results of the present study pave the way for the creation of a protocol for future validation in larger studies aimed at providing guidelines in emergency conditions.

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Quantifying competitive advantages of mutant strains in a population involving importation and mass vaccination rollout

Cited by 24 publications

References 16 publications

What Happens to the Immune System after Vaccination or Recovery from COVID-19?

What Happens to the Immune System after Vaccination or Recovery from COVID-19?

Resilience and Anxiety Among Healthcare Workers During the Spread of the SARS-CoV-2 Delta Variant: A Moderated Mediation Model

Prevention Procedures to Contain COVID-19 Contagion in the First Italian Army Field Hospital

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