Quantified Regional Cerebral Glucose Consumption, rCBF and Edema, and the Effects of Papaverine, in Cats with Cortical Cold Injury

Summary:We evaluated the effects of early posttrau matic hypoxia on neurologic function, magnetic reso nance images (MRI), brain tissue specific gravities, and cerebral blood flow (CBF) in head-injured rats. By itself, an hypoxic insult (PaOZ 40 mm Hg for 30 min) had little effect on any measure of cerebral function. After tem poral fluid-percussion impact injury, however, hypoxia significantly increased morbidity. Of rats subjected to im pact (4.9 ± 0.3 atm) plus hypoxia, 71% had motor weak ness contralateral to the impact side 24 h after injury, while only 29% of rats subjected to impact alone had de monstrable weakness (p < 0.05). Lesions observed on MR images 24 h after injury were restricted to the impact site in rats with impact injury alone, but extensive areas with longer Tl relaxation times were observed throughout the ipsilateral cortex in rats with impact in-

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Quantified Regional Cerebral Glucose Consumption, rCBF and Edema, and the Effects of Papaverine, in Cats with Cortical Cold Injury

Cited by 5 publications

References 9 publications

Blood Flow and Metabolism in Vasogenic Oedema

Blood Flow and Metabolism in Vasogenic Oedema

Effects of etoposide-induced blood-brain barrier disruption on brain water, intracranial pressure, and cerebral vasomotor tone

The Effect of Hypoxia on Traumatic Head Injury in Rats: Alterations in Neurologic Function, Brain Edema, and Cerebral Blood Flow

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