Quantified Power Doppler US of Tumor Blood Flow Correlates with Microscopic Quantification of Tumor Blood Vessels

Donnelly, Edwin F.; Geng, Li; Wojcicki, Walter E.; Fleischer, Arthur C.; Hallahan, Dennis E.

doi:10.1148/radiology.219.1.r01ap38166

Cited by 75 publications

(44 citation statements)

References 17 publications

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“…At clinical frequencies of 3 to 15 MHz, Power Doppler sonography can detect regression of larger tumor vessels during antivascular therapy (14). However, capillary blood flow in small nonstabilized vessels, which mostly respond to antiangiogenic treatments, cannot be assessed via conventional Doppler sonography.…”

Section: Introductionmentioning

confidence: 99%

Vessel Fractions in Tumor Xenografts Depicted by Flow- or Contrast-Sensitive Three-Dimensional High-Frequency Doppler Ultrasound Respond Differently to Antiangiogenic Treatment

et al. 2008

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High-frequency volumetric Power Doppler ultrasound (HF-VPDU) captures flow-dependent signals in blood vessels and can be used to assess antiangiogenic therapy effects in rodent tumors. However, the sensitivity is limited to vessels larger than capillaries. Contrast-enhanced HF-VPDU reveals all perfused vessels by assessing stimulated acoustic emissions from disintegrating microbubbles. Thus, we investigated whether flow-sensitive and contrast-enhanced HF-VPDU can depict different vessel fractions and assess their early response to antiangiogenic therapy. Mice with A431 tumors were scanned before and after administration of polybutylcyanoacrylate microbubbles by HF-VPDU. Animals received either antiangiogenic treatment (SU11248) or a control substance and were imaged repeatedly over 9 days. At each time point, tumors were removed for immunohistochemical analysis. During growth of untreated tumors, vascularization decreased correspondingly on flow-sensitive and contrast-enhanced scans. Treated tumors showed a significantly (P < 0.05) stronger decline in vascularization than controls, which was more pronounced in contrast-enhanced scans. Surprisingly, whereas vascularization remained low in contrast-enhanced scans, flow-sensitive ultrasound indicated a reincrease after day 6 with a higher vascularization than the controls at day 9. Histologic evaluation indicated that immature vessels degraded markedly on therapy, whereas large mature vessels on the tumor periphery were more therapy resistant and drew closer due to tumor shrinkage. In conclusion, contrast-enhanced HF-VPDU and flow-sensitive HF-VPDU are both capable of assessing the effects of antiangiogenic therapy. Because contrast-sensitive ultrasound is more sensitive for small immature vessels and flow-sensitive ultrasound mostly captures large vessels at the tumor periphery, the combination of both methods can provide evidence of vascular maturity in tumors. [Cancer Res 2008;68(17):7042-9]

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Section: Introductionmentioning

confidence: 99%

Vessel Fractions in Tumor Xenografts Depicted by Flow- or Contrast-Sensitive Three-Dimensional High-Frequency Doppler Ultrasound Respond Differently to Antiangiogenic Treatment

et al. 2008

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“…Since, this method requires obtaining tissue samples repeatedly by invasive biopsy, it is impractical. A number of techniques have been reported for imaging the blood vessels in solid tumors invasively and repeatedly [12,13]. Among these, power Doppler ultrasound (US) could noninvasively monitor the tumor blood flow [12].…”

Section: Introductionmentioning

confidence: 99%

“…A number of techniques have been reported for imaging the blood vessels in solid tumors invasively and repeatedly [12,13]. Among these, power Doppler ultrasound (US) could noninvasively monitor the tumor blood flow [12]. Therefore, this method could enable the assessment of the vascularity and blood perfusion within the tumor tissue after PDT.…”

Section: Introductionmentioning

confidence: 99%

Antitumor effects and blood flow dynamics after photodynamic therapy using benzoporphyrin derivative monoacid ring A in KLN205 and LM8 mouse tumor models

et al. 2007

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1 SummaryPhotodynamic therapy (PDT) using benzoporphyrin derivative monoacid ring A (BPD-MA) induces direct tumor cell damage and microvascular injury. We administered BPD-MA at 3 h or 15 min before laser irradiation to KLN205 and LM8 tumors in murine models. Tumor growth delay was induced more effectively by 15-min-interval PDT than by 3-h-interval PDT. Vascularity and blood perfusion was significantly decreased by 15-min-interval PDT. We observed death of all tumor cells, except peripheral cells, in the 3-h-interval PDT group, and death of cells around the damaged tumor vasculature in the 15-min-interval PDT group. Thus, 15-min-interval-PDT enhanced the antitumor effect by damaging tumor vasculature.2

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“…В целом для доброкачественных новообразований более характерны низкая скорость и высокая резистентность артериального кровотока, в то время как для злокачественных -высокая скорость и низкая резистентность. Это связано с тем, что во вновь образованных сосудах злокачественных опухо-лей слабо развита мышечная оболочка, сосуды хаотично расположены и имеют большое количество анастомозов, что и отличает их от питающих сосудов в доброкачествен-ных образованиях яичника [45][46][47].…”

Section: применение высокотехнологичных методов эхографии в диагностиunclassified

Differential ultrasound diagnosis of benign ovarian tumors: History and the present-day status of the problem

Vostrov¹,

Stepanov²,

Korneeva³

2015

Onkol. Z. im. P.A. Gercena

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Освещены вопросы диагностики онкологических заболеваний яичников с использованием ультразвукового исследования. Рассмотрены этапы становления ультразвукового метода в онкогинекологии, его возможности метода в диагностике рака яичников. Оценены роль и место ультразвукового исследования среди методов лучевой диагностики, применяемых в онкогинекологии. Ключевые слова: рак яичника, ультразвуковое исследование.Problems in the ultrasound diagnosis of ovarian cancers are covered. The developmental stages of a gynecological oncological ultrasound technique and its possibilities to diagnose ovarian cancer are considered. The role and place of ultrasonography are assessed among the radiodiagnostic methods used in gynecological oncology.

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Quantified Power Doppler US of Tumor Blood Flow Correlates with Microscopic Quantification of Tumor Blood Vessels

Abstract: Quantified power Doppler US is a noninvasive method for the evaluation of tumor vascularity and blood flow.

Cited by 75 publications

References 17 publications

Vessel Fractions in Tumor Xenografts Depicted by Flow- or Contrast-Sensitive Three-Dimensional High-Frequency Doppler Ultrasound Respond Differently to Antiangiogenic Treatment

Vessel Fractions in Tumor Xenografts Depicted by Flow- or Contrast-Sensitive Three-Dimensional High-Frequency Doppler Ultrasound Respond Differently to Antiangiogenic Treatment

Antitumor effects and blood flow dynamics after photodynamic therapy using benzoporphyrin derivative monoacid ring A in KLN205 and LM8 mouse tumor models

Differential ultrasound diagnosis of benign ovarian tumors: History and the present-day status of the problem

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