Quantified EEG changes associated with a positive clinical response to clozapine in schizophrenia

Lacroix, Denis; Chaput, Yves; Rodriguez, Jean-Pierre; Filion, M.; Morrison, Denis; St-Denis, Pierre; Albert, Jean-Marie

doi:10.1016/0278-5846(95)00116-d

Cited by 20 publications

(16 citation statements)

References 47 publications

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“…Our analyses focused on theta frequency changes induced by CLZ due to the evidence for low frequency EEG changes following both acute and chronic CLZ exposure within the human schizophrenia literature (e.g., Lacroix et al, 1995; Roubicek and Major, 1977). This study replicated the reduced synchrony observed between the mPFC and the dorsal HPC in MIA animals while the primary finding was that acute CLZ exposure enhanced long-range theta coherence in a dose-dependent manner (Dickerson et al, 2012).…”

Section: Hpc—mpfc Communicationmentioning

confidence: 99%

Aberrant neural synchrony in the maternal immune activation model: using translatable measures to explore targeted interventions

Dickerson

Bilkey

2013

Front. Behav. Neurosci.

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Maternal exposure to infection occurring mid-gestation produces a three-fold increase in the risk of schizophrenia in the offspring. The critical initiating factor appears to be the maternal immune activation (MIA) that follows infection. This process can be induced in rodents by exposure of pregnant dams to the viral mimic Poly I:C, which triggers an immune response that results in structural, functional, behavioral, and electrophysiological phenotypes in the adult offspring that model those seen in schizophrenia. We used this model to explore the role of synchronization in brain neural networks, a process thought to be dysfunctional in schizophrenia and previously associated with positive, negative, and cognitive symptoms of schizophrenia. Exposure of pregnant dams to Poly I:C on GD15 produced an impairment in long-range neural synchrony in adult offspring between two regions implicated in schizophrenia pathology; the hippocampus and the medial prefrontal cortex (mPFC). This reduction in synchrony was ameliorated by acute doses of the antipsychotic clozapine. MIA animals have previously been shown to have impaired pre-pulse inhibition (PPI), a gold-standard measure of schizophrenia-like deficits in animal models. Our data showed that deficits in synchrony were positively correlated with the impairments in PPI. Subsequent analysis of LFP activity during the PPI response also showed that reduced coupling between the mPFC and the hippocampus following processing of the pre-pulse was associated with reduced PPI. The ability of the MIA intervention to model neurodevelopmental aspects of schizophrenia pathology provides a useful platform from which to investigate the ontogeny of aberrant synchronous processes. Further, the way in which the model expresses translatable deficits such as aberrant synchrony and reduced PPI will allow researchers to explore novel intervention strategies targeted to these changes.

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Section: Hpc—mpfc Communicationmentioning

confidence: 99%

Aberrant neural synchrony in the maternal immune activation model: using translatable measures to explore targeted interventions

Dickerson

Bilkey

2013

Front. Behav. Neurosci.

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“…Quantitative EEG studies have reported an increase in theta and delta power and coherence changes in theta band following clozapine treatment 26. In that study, changes of coherence were correlated with changes on the Brief Psychiatric Rating Scale score, thus to clinical improvement.…”

Section: Discussionmentioning

confidence: 86%

Electroencephalographic Abnormalities in Clozapine-Treated Patients: A Cross-Sectional Study

Goyal

Praharaj

Desarkar

et al. 2011

Psychiatry Investig

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The objective of our study was to examine the electroencephalogram (EEG) abnormalities associated with clozapine treatment. It was a cross-sectional study on 87 psychiatric patients on clozapine treatment. 32 channel digital EEG was recorded and analysed visually for abnormalities. EEG abnormalities were observed in 63.2% of patients. Both slowing and epileptiform activities were noted in 41.4% of patients. The EEG abnormalities were not associated with dose or duration of clozapine exposure.

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“…However, the nature of these changes and a link with clozapine response have, at best, been inconsistent (Koukkou et al 1979;Tiihonen et al 1991;Lacroix et al 1995;Risby et al 1995;Pillay et al 1996;Treves and Neufeld 1996;Gross et al 2004). …”

Section: Neurologicalmentioning

confidence: 93%

“…Variable Abnormal EEGs before treatment linked to better response, but only in certain subgroups, i.e., females with abnormalities versus females without; patients with a concomitant major depressive episode versus those without Treves and Neufeld 1996 15 Variable With treatment, trend toward more frequent abnormal EEGs in those with better clinical response and/or shorter duration of illness Lacroix et al 1995 10…”

Section: Cognitive/neuropsychologicalmentioning

confidence: 97%

Predictors and markers of clozapine response

Chung

Remington

2005

Psychopharmacology

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Quantified EEG changes associated with a positive clinical response to clozapine in schizophrenia

Cited by 20 publications

References 47 publications

Aberrant neural synchrony in the maternal immune activation model: using translatable measures to explore targeted interventions

Aberrant neural synchrony in the maternal immune activation model: using translatable measures to explore targeted interventions

Electroencephalographic Abnormalities in Clozapine-Treated Patients: A Cross-Sectional Study

Predictors and markers of clozapine response

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