Quantification of Wall Shear Stress in Large Blood Vessels Using Lagrangian Interpolation Functions with Cine Phase-Contrast Magnetic Resonance Imaging

Cheng, Christopher P.; Parker, David; Taylor, Charles A.

doi:10.1114/1.1511239

Cited by 100 publications

(90 citation statements)

References 27 publications

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“…In this study, μ was 1 cP. Q is the flow rate of the bioreactor, which ranged from 0 to 1000 ml/min, and r is the radius of the scaffolds [16] . Direct exposure of MSCs seeded onto the tubular scaffolds to shear stress of a physiological level (15 dyne/cm 2 ) would cause the cells to detach from the scaffolds.…”

Section: Methodsmentioning

confidence: 99%

Response of mesenchymal stem cells to shear stress in tissue-engineered vascular grafts

Dong

et al. 2009

Acta Pharmacol Sin

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Aim: Recent studies have demonstrated that mesenchymal stem cells (MSCs) can differentiate into endothelial cells. The effect of shear stress on MSC differentiation is incompletely understood, and most studies have been based on two-dimensional systems. We used a model of tissue-engineered vascular grafts (TEVGs) to investigate the effects of shear stress on MSC differentiation. Methods: MSCs were isolated from canine bone marrow. The TEVG was constructed by seeding MSCs onto poly-ε-caprolactone and lactic acid (PCLA) scaffolds and subjecting them to shear stress provided by a pulsatile bioreactor for four days (two days at 1 dyne/cm 2 to 15 dyne/cm 2 and two days at 15 dyne/cm 2 ). Results: Shear stress significantly increased the expression of endothelial cell markers, such as platelet-endothelial cell adhesion molecule-1 (PECAM-1), VE-cadherin, and CD34, at both the mRNA and protein levels as compared with static control cells. Protein levels of alpha-smooth muscle actin (α-SMA) and calponin were substantially reduced in shear stresscultured cells. There was no significant change in the expression of α-SMA, smooth muscle myosin heavy chain (SMMHC) or calponin at the mRNA level. Conclusion: Shear stress upregulated the expression of endothelial cell-related markers and downregulated smooth muscle-related markers in canine MSCs. This study may serve as a basis for further investigation of the effects of shear stress on MSC differentiation in TEVGs.

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Section: Methodsmentioning

confidence: 99%

Response of mesenchymal stem cells to shear stress in tissue-engineered vascular grafts

Dong

et al. 2009

Acta Pharmacol Sin

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“…This large error is due to the nonlinear velocity profile at the wall and ignorance of the radial derivatives. Enhancement was recently reported by Cheng et al (2002) by introducing piecewise Lagrangian basis functions and segmenting the vessel lumen with a level set method.…”

Section: Shear Stressmentioning

confidence: 99%

“…Although being studied by many authors (e.g. Womersley, 1955;McDonald, 1974;Caro et al, 1978;Ku et al, 1985;Moore et al, 1994a, b;Reneman et al, 1993;Taylor et al, 1996;Gijsen et al, 1997;Vorp et al, 1998;Wootton and Ku, 1999), the relation between flow fields and cardiovascular diseases is still not fully understood, and is currently receiving more and more attention (Botnar et al, 2000;Berthier et al, 2002;Cheng et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Mesoscopic simulations of systolic flow in the human abdominal aorta

Artoli

Hoekstra

Sloot

2006

Journal of Biomechanics

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The complex nature of blood flow in the human arterial system is still gaining more attention, as it has become clear that cardiovascular diseases localize in regions of complex geometry and complex flow fields. In this article, we demonstrate that the lattice Boltzmann method can serve as a mesoscopic computational hemodynamic solver. We argue that it may have benefits over the traditional Navier-Stokes techniques. The accuracy of the method is tested by studying time-dependent systolic flow in a 3D straight rigid tube at typical hemodynamic Reynolds and Womersley numbers as an unsteady flow benchmark. Simulation results of steady and unsteady flow in a model of the human aortic bifurcation reconstructed from magnetic resonance angiography, are presented as a typical hemodynamic application. r

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“…Level set-based segmentation of the wall together with cubic Lagrangian interpolation has been used for MRI-based WSS estimation in large vessels [92]. According to the no-slip condition, the velocity should be zero at the wall.…”

Section: Parabolic and Cubic Spline-based Methodsmentioning

confidence: 99%

Fast and Accurate 4D Flow MRI for Cardiovascular Blood Flow Assessment

Petersson¹

2013

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The study of blood flow is essential in understanding the physiology and pathophysiology of the cardiovascular system. Small disturbances of the blood flow may over time evolve and contribute to cardiovascular pathology. While the blood flow in a healthy human appears to be predominately laminar, turbulent or transitional blood flow is thought to be involved in the pathogenesis of several cardiovascular diseases. Wall shear stress is the frictional force of blood on the vessel wall and has been linked to the pathogenesis of atherosclerosis and aneurysms. Despite the importance of hemodynamic factors, cardiovascular diagnostics largely relies on the indirect estimation of function based on morphological data.Time-resolved three-dimensional (3D) phase-contrast magnetic resonance imaging (MRI), often referred to as 4D flow MRI, is a versatile and non-invasive tool for cardiovascular blood flow assessment. The use of 4D flow MRI permits estimation of flow volumes, pressure losses, wall shear stress, turbulence intensity and many other unique hemodynamic parameters. However, 4D flow MRI suffers from long scan times, sometimes over 40 minutes. Furthermore, the accuracy of the many different 4D flow MRI-based applications and estimates have not been thoroughly examined.In this thesis, the accuracy of 4D flow MRI-based turbulence intensity mapping and wall shear stress estimation was investigated by using numerical simulations of MRI flow measurements. While the results from the turbulence intensity mapping agreed well with reference values from computational fluid dynamics data, the accuracy of the MRI-based wall shear stress estimates was found to be very sensitive to different parameters, especially to spatial resolution, and wall shear stress values over 5 N/m 2 were not well resolved.To reduce the scan time, a 4D flow MRI sequence using spiral k-space trajectories was implemented and validated in-vivo and in-vitro. The scan time of 4D flow MRI was reduced by more than two-fold compared to a conventional Cartesian acquisition already accelerated using SENSE factor 2, and the data quality was maintained. For a 4D flow scan of the human heart, the use of spiral k-space trajectories resulted in a scan time of around 13 min, compared to 30 min for the Cartesian acquisition. By combining parallel imaging and spiral trajectories, the total scan time of a 4D flow measurement of the entire heart may be further reduced. This scan time reduction may also be traded for higher spatial resolution.Numerical simulation of 4D flow MRI may act as an important tool for future optimization and validation of the spiral 4D flow sequence. The scan-time reductions offered by the spiral k-space trajectories can help to cut costs, save time, reduce discomfort for the patient as well as to decrease the risk for motion artifacts. These benefits may facilitate an expanded clinical and investigative use of 4D flow MRI, including larger patient research studies.v Populärvetenskaplig sammanfattningHjärt-och kärlsjukdom är fortfarande den ...

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Quantification of Wall Shear Stress in Large Blood Vessels Using Lagrangian Interpolation Functions with Cine Phase-Contrast Magnetic Resonance Imaging

Cited by 100 publications

References 27 publications

Response of mesenchymal stem cells to shear stress in tissue-engineered vascular grafts

Response of mesenchymal stem cells to shear stress in tissue-engineered vascular grafts

Mesoscopic simulations of systolic flow in the human abdominal aorta

Fast and Accurate 4D Flow MRI for Cardiovascular Blood Flow Assessment

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