Quantification of tumor necrosis factor-α and matrix metalloproteinases-3 in synovial fluid by a fiber-optic particle plasmon resonance sensor

Huang, Yi‐Ching; Chiang, Chao-Lung; Li, Cheng-Hen; Chang, Ting-Chou; Chiang, Chung-Sheng; Chau, Lai-Kwan; Huang, Kuo‐Wei; Wu, Chin-Wei; Wang, Shau‐Chun; Lyu, Shaw-Ruey

doi:10.1039/c3an00276d

Cited by 54 publications

(41 citation statements)

References 42 publications

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“…An LSPR sensor has been used to measure recombinant IL-6 produced from E.Coli [238]. A fiber optic with gold nanoparticles was used to measure TNF-α from synovial fluid with detection limits reported of 34 pg/mL [239]. This group also measured IL-1β in a separate study down to 21 pg/mL for the LOD [236].…”

Section: Optical Methodsmentioning

confidence: 99%

Bioanalytical chemistry of cytokines – A review

Stenken

Poschenrieder

2015

Analytica Chimica Acta

237

172

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Cytokines are bioactive proteins produced by many different cells of the immune system. Due to their role in different inflammatory disease states and maintaining homeostasis, there is enormous clinical interest in the quantitation of cytokines. The typical standard methods for quantitation of cytokines are immunoassay-based techniques including enzyme-linked immusorbent assays (ELISA) and bead-based immunoassays read by either standard or modified flow cytometers. A review of recent developments in analytical methods for measurements of cytokine proteins is provided. This review briefly covers cytokine biology and the analysis challenges associated with measurement of these biomarker proteins for understanding both health and disease. New techniques applied to immunoassay-based assays are presented along with the uses of aptamers, electrochemistry, mass spectrometry, optical resonator-based methods. Methods used for elucidating the release of cytokines from single cells as well as in vivo collection methods are described.

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Section: Optical Methodsmentioning

confidence: 99%

Bioanalytical chemistry of cytokines – A review

Stenken

Poschenrieder

2015

Analytica Chimica Acta

237

172

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“…To improve the intrinsically low absorbance existing in NP submonolayers, a fiber-optic particle plasmon resonance (FOPPR) sensor was used in several studies [122,123] In the FOPPR sensor displayed in Figure 16, evanescent waves propagating along an optical fiber can excite AuNPs immobilized on the fiber surface. Similar to the conventional LSPR, the plasmon absorbance of antibody-functionalized AuNPs increases upon antigen binding, leading to a decrease in the light transmitted through the optical fiber.…”

Section: Cytokine Sensors With Various Optical Modes Of Detectionmentioning

confidence: 99%

“…Unlike the relatively long assay time needed for LSPR, the FOPPR sensor was shown to display steady signal in less than 10 min. For TNF-α in synovial fluid, the FOPPR sensor yielded a 8.2 pg/mL (0.48 pM) DL although the detection required a relatively large sample volume of 200 μL and dilutions of the biological fluids to prevent bulk refractive index changes [123]. The dilution of samples is not just imposed on the SPR- and LSPR-based sensors but is often required for all optical detection modes relying on detecting the refractive index variation upon analyte binding.…”

Section: Cytokine Sensors With Various Optical Modes Of Detectionmentioning

confidence: 99%

Emerging Cytokine Biosensors with Optical Detection Modalities and Nanomaterial-Enabled Signal Enhancement

Singh

Truong

Reeves

et al. 2017

Sensors

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Protein biomarkers, especially cytokines, play a pivotal role in the diagnosis and treatment of a wide spectrum of diseases. Therefore, a critical need for advanced cytokine sensors has been rapidly growing and will continue to expand to promote clinical testing, new biomarker development, and disease studies. In particular, sensors employing transduction principles of various optical modalities have emerged as the most common means of detection. In typical cytokine assays which are based on the binding affinities between the analytes of cytokines and their specific antibodies, optical schemes represent the most widely used mechanisms, with some serving as the gold standard against which all existing and new sensors are benchmarked. With recent advancements in nanoscience and nanotechnology, many of the recently emerging technologies for cytokine detection exploit various forms of nanomaterials for improved sensing capabilities. Nanomaterials have been demonstrated to exhibit exceptional optical properties unique to their reduced dimensionality. Novel sensing approaches based on the newly identified properties of nanomaterials have shown drastically improved performances in both the qualitative and quantitative analyses of cytokines. This article brings together the fundamentals in the literature that are central to different optical modalities developed for cytokine detection. Recent advancements in the applications of novel technologies are also discussed in terms of those that enable highly sensitive and multiplexed cytokine quantification spanning a wide dynamic range. For each highlighted optical technique, its current detection capabilities as well as associated challenges are discussed. Lastly, an outlook for nanomaterial-based cytokine sensors is provided from the perspective of optimizing the technologies for sensitivity and multiplexity as well as promoting widespread adaptations of the emerging optical techniques by lowering high thresholds currently present in the new approaches.

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“…This makes it undesirable to implement such an assay for rapid immune diagnosis with high statistical accuracy. By integrating the LSPR biosensors with fiber optics, Chiang et al and Huang et al detected IL-1β and TNF-α at tens of pg/mL within less than 10 mins [83, 84]. However, these sensors need to dip the fiber probe into a large volume of sample for detection, making the implementation of such sensors for clinical application impractical.…”

Section: Label-free Cytokine Biosensingmentioning

confidence: 99%

Label-free cytokine micro- and nano-biosensing towards personalized medicine of systemic inflammatory disorders

Chen

Huang

Chung

et al. 2015

Advanced Drug Delivery Reviews

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Systemic inflammatory disorders resulting from infection, trauma, surgery, and severe disease conditions pose serious threats to human health leading to organ dysfunction, organ failure, and mortality. The highly complex and dynamic nature of the immune system experiencing acute inflammation makes immunomodulatory therapy blocking pro-inflammatory cytokines very challenging. Successful therapy requires the ability to determine appropriate anti-cytokine drugs to be delivered at a right dose in a timely manner. Label-free micro- and nano-biosensors hold the potential to overcome the current challenges, enabling cytokine-targeted treatments to be tailored according to the immune status of an individual host with their unique cytokine biomarker detection capabilities. This review studies the recent progress in label-free cytokine biosensors, summarizes their performances and potential merits, and discusses future directions for their advancements to meet challenges towards personalized anti-cytokine drug delivery.

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Quantification of tumor necrosis factor-α and matrix metalloproteinases-3 in synovial fluid by a fiber-optic particle plasmon resonance sensor

Cited by 54 publications

References 42 publications

Bioanalytical chemistry of cytokines – A review

Bioanalytical chemistry of cytokines – A review

Emerging Cytokine Biosensors with Optical Detection Modalities and Nanomaterial-Enabled Signal Enhancement

Label-free cytokine micro- and nano-biosensing towards personalized medicine of systemic inflammatory disorders

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