Quantification of Treadmill Exercise Required for Improvement of Tiialuum-201 Image Quality

Stern, Steven; Greenberg, I D; Corne, Robert A.

doi:10.1097/00003072-199110000-00030

Cited by 3 publications

(3 citation statements)

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“…These ratios were calculated by applying a different procedure from that reported previously for other cardiac agents (8,9,11), wherein only a tiny section of tissues surrounding the heart region was selected (8) or region-of-interest selection was not precisely defined (11). This procedure provided unequivocal results and is consistent with more accurate methods that have been described (18,19).…”

Section: Discussionsupporting

confidence: 81%

Whole-Body Biodistribution and Radiation Dosimetry of the New Cardiac Tracer ^99mTc-N-DBODC

Cittanti¹,

Uccelli²,

Pasquali³

et al. 2008

J Nucl Med

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Our purpose was to evaluate the safety profile and biodistribution behavior in healthy human volunteers of the new myocardial perfusion tracer bis [(dimethoxypropylphosphanyl)ethyl]ethoxyethylamine N, N9-bis(ethoxyethyl)dithiocarbamato nitrido technetium (V) ( 99m Tc-N-DBODC). Methods: Ten healthy male volunteers were injected with 99m Tc-N-DBODC under both stress and rest conditions. Anterior and posterior planar g-camera images were collected at 5, 30, 60, 240, and 1,440 min after injection, with organ uptake quantified by region-of-interest analysis. Tracer kinetics in body fluids were determined by collecting blood and urine samples at different time points. Results: After injection, 99m Tc-N-DBODC showed significant accumulation in the myocardium and prolonged retention. Under rest conditions, uptake in the heart, lungs, and liver at 5 min after injection was 1.67% 6 0.13%, 1.16% 6 0.07%, and 10.85% 6 1.72%, respectively, of administered activity. Under stress conditions, heart uptake was significantly higher (2.07% 6 0.22%). Radioactivity in the liver decreased to 3.64% 6 0.98% and 2.37% 6 0.48% at 60 and 240 min, respectively, after injection. This rapid liver clearance led to favorable heart-to-liver ratios, reaching values of 0.74 6 0.13 at rest and 1.26 6 0.28 during exercise 60 min after tracer administration. Radiation dose estimates were comparable to those obtained with other myocardial perfusion cationic compounds. Conclusion: The high uptake in the myocardium and the fast liver washout of 99m Tc-N-DBODC will allow SPECT images of the left ventricle to be acquired early and with excellent quality. Previ ously, we described a new class of asymmetric, monocationic nitrido 99m Tc complexes (1,2). The biodistribution behavior of the derivative bis [(dimethoxypropylphosphanyl)-ethyl]ethoxyethylamine N,N9-bis(ethoxyethyl)dithiocarbamato nitrido technetium(V) ( 99m Tc-N-DBODC; Fig. 1) was studied extensively in rats (3,4) and dogs (5) and compared with that of the commercial radiopharmaceuticals 99m Tc-sestamibi (Cardiolite; Bristol-Myers Squibb Medical Imaging, Inc.) and 99m Tctetrofosmin (Myoview; GE Healthcare). These results in animals showed that heart uptake of 99m Tc-N-DBODC and washout from blood and lungs, as well as kinetic behavior as determined in dogs, are similar to those of the other 2 cardiac agents (5). However, a dramatic difference was observed in liver washout, which was remarkably rapid and quantitative. In particular, at 60 min after injection in rats, the heart-to-liver ratio of 99m Tc-N-DBODC was approximately 10 times higher than that of 99m Tcsestamibi and 99m Tc-tetrofosmin (2-4). On the basis of these promising results, this study was designed to evaluate the safety profile and the biodistribution of 99m Tc-N-DBODC in healthy human volunteers under both stress and rest conditions. MATERIALS AND METHODS Study PopulationThe study group included 10 healthy male volunteers (mean age 6 SD, 40.6 6 10.2 y; range, 29-54 y), with no risk factors or symptoms of cardiovascular disease an...

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Section: Discussionsupporting

confidence: 81%

Whole-Body Biodistribution and Radiation Dosimetry of the New Cardiac Tracer ^99mTc-N-DBODC

Cittanti¹,

Uccelli²,

Pasquali³

et al. 2008

J Nucl Med

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“…This significantly reduces the side effects and improves image quality. [23][24][25][26] Low-level exercise supplementation is not recommended for patients with LBBB, WPW, and ventricular pacing due to heart rate-related imaging artifacts.…”

Section: Dipyridamolementioning

confidence: 99%

ASNC imaging guidelines for SPECT nuclear cardiology procedures: Stress, protocols, and tracers

Henzlova

Duvall

Einstein

et al. 2016

Journal of Nuclear Cardiology

515

386

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“…Der Anteil der myokardialen an der Ganzkörper-Aktivität und das Verhältnis der myokardialen zur pulmonalen Aktivität sind für die drei Untersuchungen in Tab (11,12,16). In Kombination mit einer submaximalen Ergometrie ließ sich die Spezifität bei verminderter Anreicherung im Darmbereich steigern (18). Einschränkungen bestehen jedoch bei Asthmatikern oder Personen mit allergischen Reaktionen in der Anamnese.…”

Section: Ganzkörper-aktivitätsverteilungunclassified

Ganzkörperverteilung von Tc-99m-Sestamibi nach pharmakologischer Belastung mit Arbutamin und Dipyridamol im Vergleich zum Ruhezustand

Kotzerke¹,

Bergmann²,

Glatz³

et al. 1997

Nuklearmedizin

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Zusammenfassung Ziel: Der neue Beta-adrenerge Rezeptoren-Agonist Arbutamin (GenESA®, Gensia Europe Ltd., Berkshire, England) wurde speziell für den pharmakologischen Streß zum Nachweis einer koronaren Herzerkrankung entwickelt und stellt damit auch für die Belastungsmyokardszintigraphie eine Option dar. Die pharmakologische Wirkung kann im Vergleich zum Vasodilatator Dipyridamol anhand der Ganzkörper-Aktivitätsverteilung nach Applikation von Tc-99m-Sestamibi bestimmt werden. Methoden: Untersucht wurden 9 Patienten nach Applikation von Tc-99m-Sestamibi unter Ruhebedingung, nach Steigerung der myokardialen Perfusion durch Infusion von Arbutamin und unter maximaler Vasodilatation durch Infusion von Dipyridamol. Ergebnisse: Nach Gabe von Arbutamin bestand eine szintigraphisch meßbare verminderte Radiotracereinlagerung in der unteren Extremität. Gegenüber Dipyridamol war die myokardiale Akkumulation von Tc-99m-Sestamibi trotzdem vermindert, was sich neben dem relativen Anteil des Herzens an der Ganzkörperaktivität (2,1% ± 0,5% gegenüber 2,4% ± 0,4%, p <0,05) auch an einem niedrigeren Herz-Lungen-Quotienten (2,5 ± 0,4 gegenüber 2,8 ± 0,5, p <0,05) zeigte. Schlußfolgerung: Nach Infusion von Arbutamin ist sowohl der Anteil von myokardial deponiertem Tc-99m-Sestamibi als auch der Kontrast des Myokards zur umgebenden Lunge geringer als nach Gabe von Dipyridamol. Ob dieser Unterschied für die Diagnose myokardialer Perfusionsstörungen mit Tc-99m-Sestamibi relevant ist, muß noch überprüft werden.

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Quantification of Treadmill Exercise Required for Improvement of Tiialuum-201 Image Quality

Cited by 3 publications

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Whole-Body Biodistribution and Radiation Dosimetry of the New Cardiac Tracer ^99mTc-N-DBODC

Whole-Body Biodistribution and Radiation Dosimetry of the New Cardiac Tracer ^99mTc-N-DBODC

ASNC imaging guidelines for SPECT nuclear cardiology procedures: Stress, protocols, and tracers

Ganzkörperverteilung von Tc-99m-Sestamibi nach pharmakologischer Belastung mit Arbutamin und Dipyridamol im Vergleich zum Ruhezustand

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Quantification of Treadmill Exercise Required for Improvement of Tiialuum-201 Image Quality

Cited by 3 publications

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Whole-Body Biodistribution and Radiation Dosimetry of the New Cardiac Tracer 99mTc-N-DBODC

Whole-Body Biodistribution and Radiation Dosimetry of the New Cardiac Tracer 99mTc-N-DBODC

ASNC imaging guidelines for SPECT nuclear cardiology procedures: Stress, protocols, and tracers

Ganzkörperverteilung von Tc-99m-Sestamibi nach pharmakologischer Belastung mit Arbutamin und Dipyridamol im Vergleich zum Ruhezustand

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Whole-Body Biodistribution and Radiation Dosimetry of the New Cardiac Tracer ^99mTc-N-DBODC

Whole-Body Biodistribution and Radiation Dosimetry of the New Cardiac Tracer ^99mTc-N-DBODC