Quantification of the wound healing using polarization-sensitive optical coherence tomography

Oh, Jung Taek; Lee, Sang-Won; Kim, Youn Soo; Suhr, Ki Beom; Kim, Beop Min

doi:10.1117/1.2338826

Cited by 32 publications

(26 citation statements)

References 12 publications

(12 reference statements)

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“…Figure 7j shows an example of scarred skin exhibiting significantly higher birefringence than normal skin (Figure 7i). Additionally, wound healing processes including collagen restoration can be followed with PS-OCT [180,181]. Moreover, Stokes vector based Via dermal birefringence, PS-OCT provides access to tissue alterations caused by deformation, scarring, and burns [106,[177][178][179].…”

Section: Ps-oct In Skin and Oropharyngeal Tissuementioning

confidence: 99%

“…Figure 7j shows an example of scarred skin exhibiting significantly higher birefringence than normal skin (Figure 7i). Additionally, wound healing processes including collagen restoration can be followed with PS-OCT [180,181]. Moreover, Stokes vector based depolarization imaging can reveal multiple scattering as well as pathological conditions in skin such as cancer [19,24,58], as will be discussed in the next section.…”

Section: Ps-oct In Skin and Oropharyngeal Tissuementioning

confidence: 99%

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Polarization Sensitive Optical Coherence Tomography: A Review of Technology and Applications

Baumann

2017

Applied Sciences

128

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Polarization sensitive optical coherence tomography (PS-OCT) is an imaging technique based on light scattering. PS-OCT performs rapid two-and three-dimensional imaging of transparent and translucent samples with micrometer scale resolution. PS-OCT provides image contrast based on the polarization state of backscattered light and has been applied in many biomedical fields as well as in non-medical fields. Thereby, the polarimetric approach enabled imaging with enhanced contrast compared to standard OCT and the quantitative assessment of sample polarization properties. In this article, the basic methodological principles, the state of the art of PS-OCT technologies, and important applications of the technique are reviewed in a concise yet comprehensive way.

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Section: Ps-oct In Skin and Oropharyngeal Tissuementioning

confidence: 99%

“…Figure 7j shows an example of scarred skin exhibiting significantly higher birefringence than normal skin (Figure 7i). Additionally, wound healing processes including collagen restoration can be followed with PS-OCT [180,181]. Moreover, Stokes vector based depolarization imaging can reveal multiple scattering as well as pathological conditions in skin such as cancer [19,24,58], as will be discussed in the next section.…”

Section: Ps-oct In Skin and Oropharyngeal Tissuementioning

confidence: 99%

Polarization Sensitive Optical Coherence Tomography: A Review of Technology and Applications

Baumann

2017

Applied Sciences

128

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“…Tissues with a high collagen content have high phase retardation slopes (solid line in fig. 2c), which have been used to quantitatively assess the collagen content in biological samples [14,19,20,21]. …”

Section: Methodsmentioning

confidence: 99%

The Use of Collagen Content as Determined by Spectral Domain Polarization-Sensitive Optical Coherence Tomography to Assess Colon Anastomosis Healing in a Rat Model

Son

Jeong²,

Jung

et al. 2014

Eur Surg Res

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Background/Purpose: Many studies have been undertaken to prevent anastomosis leakage of the colon, and several methods have been used to assess anastomosis healing, such as measurement of bursting pressure or hydroxyproline (a marker of collagen) content at the anastomosis site. However, these methods are inappropriate for comparing anastomosis healing at two time points in the same animals. In the present study, we measured the collagen level by spectral domain polarization-sensitive optical coherence tomography (SD-PS-OCT) to assess anastomosis healing. Methods: Sprague-Dawley rats were divided into groups C (saline-administered controls; study group) and M [a 5-fluorouracil (5-FU)-administered experimental group]. Immediately after end-to-end anastomosis of the colon, SD-PS-OCT images of anastomoses were taken (baseline). Animals were administered saline or 5-FU for 7 days. On the 7th postoperative day, SD-PS-OCT images were acquired, a histopathologic exam was performed, and hydroxyproline levels as well as mRNA expressions of collagen-1 and collagen-3 were measured at the anastomosis site. Results: Fibroblast proliferation and inflammatory cell infiltration were greater in group C than in group M. The mRNA expressions of collagen-1 and collagen-3 were substantially higher in group C. Hydroxyproline levels were higher in group M than in group C. Though collagen levels measured by SD-PS-OCT at 7 days were elevated compared with baseline in group C, no such changes were observed for group M. Conclusion: Collagen levels at the colon anastomosis site, measured with SD-PS-OCT, were not increased at 7 days postoperatively versus baseline when 5-FU was injected, but were increased in saline-treated controls. The measurement of collagen content by SD-PS-OCT was found to provide a good means of assessing anastomosis healing, because it allows in situ assessment of collagen contents at baseline and during the postoperative period.

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“…139 For example, quantification of the normalized birefringence and mean phase retardation during wound healing using PS-OCT has been demonstrated in an in vivo rabbit auricle model in 2006. 140 From monitoring the changes in birefringence over the healing process, they found an increase in birefringence with time. Gong et al 141 assessed the collagen structure of different human scars using an enface birefringence map calculated from the rate of change of the phase retardation.…”

Section: Polarization-sensitive Optical Coherence Tomographymentioning

confidence: 99%

Review of near-infrared methods for wound assessment

Sowa

Kuo²,

et al. 2016

J. Biomed. Opt

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Quantification of the wound healing using polarization-sensitive optical coherence tomography

Cited by 32 publications

References 12 publications

Polarization Sensitive Optical Coherence Tomography: A Review of Technology and Applications

Polarization Sensitive Optical Coherence Tomography: A Review of Technology and Applications

The Use of Collagen Content as Determined by Spectral Domain Polarization-Sensitive Optical Coherence Tomography to Assess Colon Anastomosis Healing in a Rat Model

Review of near-infrared methods for wound assessment

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