Quantification of the UPDRS rigidity scale

Patrick, Susan K.; Denington, A.A.; Gauthier, Michel; Gillard, D.M.; Procházka, A.

doi:10.1109/7333.918274

Cited by 83 publications

(69 citation statements)

References 24 publications

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“…Finger angular velocity was measured with solid state gyroscopes (model G-1, NeuroKinetics, Edmonton, Alberta, Canada), and bradykinesia was determined from the peak of the resulting power spectrum. The finger tapping trials were interleaved with rigidity measurements using a clinical impedance measurement device (model RA-1, NeuroKinetics) which has been validated against UPDRS item 22 (Patrick et al, 2001). …”

Section: Clinical Evaluationmentioning

confidence: 99%

Patient-specific analysis of the volume of tissue activated during deep brain stimulation

et al. 2007

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Despite the clinical success of deep brain stimulation (DBS) for the treatment of movement disorders, many questions remain about its effects on the nervous system. We have developed a methodology to predict the volume of tissue activated (VTA) by DBS on a patient-specific basis. Our goals are to identify the intersection between the VTA and surrounding anatomical structures and to compare activation of these structures with clinical outcomes. The model system consists of three fundamental components: 1) a 3D anatomical model of the subcortical nuclei and DBS electrode position in the brain, each derived from magnetic resonance imaging (MRI); 2) a finite element model of the DBS electrode and electric field transmitted to the brain, with tissue conductivity properties derived from diffusion tensor MRI; 3) VTA prediction derived from the response of myelinated axons to the applied electric field, which is a function of the stimulation parameters (contact, impedance, voltage, pulse width, frequency). We used this model system to analyze the effects of subthalamic nucleus (STN) DBS in a patient with Parkinson's disease. Quantitative measurements of bradykinesia, rigidity, and corticospinal tract (CST) motor thresholds were evaluated over a range of stimulation parameter settings. Our model predictions showed good agreement with CST thresholds. Additionally, stimulation through electrode contacts that improved bradykinesia and rigidity generated VTAs that overlapped the zona incerta / fields of Forel (ZI/H2). Application of DBS technology to various neurological disorders has preceded scientific characterization of the volume of tissue directly affected by the stimulation. Synergistic integration of clinical analysis, neuroimaging, neuroanatomy, and neurostimulation modeling provides the opportunity to address wide ranging questions on the factors linked with the therapeutic benefits and side effects of DBS.

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Section: Clinical Evaluationmentioning

confidence: 99%

Patient-specific analysis of the volume of tissue activated during deep brain stimulation

et al. 2007

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“…The validity and reliability of the device and its use in measuring parkinsonian rigidity have been described (Patrick et al, 2001;Prochazka et al, 1997). Briefly, the device consists of an inflatable cuff force transducer and a gyro-based velocity sensor.…”

Section: Quantitative Measures Of Motor Behavior Rigiditymentioning

confidence: 99%

“…Thus, a 50-second trial yields a 46-second recording of impedance, that reliably reflects clinically rated parkinsonian rigidity (Patrick et al, 2001). Impedance data were analyzed offline using Origin statistical software (OriginLab, Northampton, MA).…”

Section: Data Analysis Rigiditymentioning

confidence: 99%

Unilateral subthalamic nucleus stimulation has a measurable ipsilateral effect on rigidity and bradykinesia in parkinson disease

Tabbal

Ushe

Mink

et al. 2008

Experimental Neurology

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“…Various methods of measuring the classical symptoms of PD in an objective and quantitative way have been proposed (Ghika et al 1993;Jobbagy et al 1998), specifically for tapping test (Ziv et al 1999;Yahalom et al 2004), the quantification of rigidity (Patrick et al 2001), handwriting (Eichhorn et al 1996), to evaluate FOG (Han et al 2003;Moore et al 2008), or to assess MBs in hand movements (Popovic et al 2002). Ghika et al (1993) designed portable system based upon a PC to measure tremor, bradikinezia, and muscle tone.…”

mentioning

confidence: 99%

“…Ziv et al (1999) developed method for computerized quantitative measurements of the frequency, duration and temporal profile of MMBs during performance of manual tapping test. Patrick et al (2001) designed a device to quantify rigidity at the elbow and the wrist. The method quantifies the clinical examination with sensors that monitor forces and angular displacements imposed by clinician onto the limb segment distal to the joint being evaluated.…”

mentioning

confidence: 99%

A Method to Assess Hand Motor Blocks in Parkinson's Disease with Digitizing Tablet

Popović

Džoljić²,

Kostić³

2008

Tohoku J. Exp. Med.

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The non-volitional sudden discontinuation of motor activity, called motor block (MB) or freezing is most commonly associated with Parkinson's disease (PD). MB extends beyond the classical manifestations of PD: akinezia, bradykinezia, rigidity, tremor, and postural instability. MB has been observed and quantified in internally cued repetitive movements such as gait, speech, handwriting, and manual tapping tasks as a distinct feature of PD. We present a simple measurement system for objective evaluation of MB during point-to-point hand movements in patients with PD. Hand trajectories were evaluated in eight PD patients based on values obtained from a digitizing tablet (DT) score. 50 trials per day were recorded in seven consecutive working days. Subjects were instructed to consciously prepare and self-initiate movements between arbitrarily fixed starting and target points without lifting a wireless magnetic mouse. MB was identified as the time interval during movement with no change in coordinates. We analyzed three kinematic parameters: duration, start and number of MBs. If MBs were documented, the DT score was 1, if not, 0. Results were then compared with the ratings of the question in motor section related to freezing of hands from the Unified Parkinson's Disease Rating Scale (UPDRS). For all patients, DT score was in agreement with the UPDRS. Present results indicate that DT is useful for assessing MBs during volitional planar hand movement. This low-cost instrument may be included in a clinical test battery because of short testing time and troublefree preparation of patient.Parkinson's disease; motor block; freezing; digitizing tablet; assessment.Tohoku

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Quantification of the UPDRS rigidity scale

Cited by 83 publications

References 24 publications

Patient-specific analysis of the volume of tissue activated during deep brain stimulation

Patient-specific analysis of the volume of tissue activated during deep brain stimulation

Unilateral subthalamic nucleus stimulation has a measurable ipsilateral effect on rigidity and bradykinesia in parkinson disease

A Method to Assess Hand Motor Blocks in Parkinson's Disease with Digitizing Tablet

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