Quantification of suppression of bitterness using an electronic tongue

Takagi, Sou; Toko, Kiyoshi; Wada, Koichi; Ohki, Toshimitsu

doi:10.1002/jps.1155.abs

Cited by 19 publications

(23 citation statements)

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“…4) Sodium carboxymethyl b-CyD was obtained from Cylcolab, Budapest. Sodium tetraphenylborate, o-nitrophenyl octyl ether, tetrahydrofuran, and calix [6]arene 6-sulfate were obtained from Dojindo Laboratories Kumamoto. Polyethylene glycol 8000 was from INC Biochemicals.…”

Section: Methodsmentioning

confidence: 99%

“…For instance, Toko et al have developed a multi-channel taste sensor whose transducer is composed of several kinds of lipid/polymer membranes with different characteristics. [5][6][7] This sensor is used to taste foods and medicines objectively, instead of human sensory evaluation. [5][6][7][8][9][10][11] The majority of the orally administrated drugs tastes very bitter.…”

mentioning

confidence: 99%

“…[5][6][7] This sensor is used to taste foods and medicines objectively, instead of human sensory evaluation. [5][6][7][8][9][10][11] The majority of the orally administrated drugs tastes very bitter. Such drugs are usually administrated as tablets.…”

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confidence: 99%

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Masking Mechanisms of Bitter Taste of Drugs Studied with Ion Selective Electrodes

et al. 2006

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The masking mechanisms of the bitter taste of propantheline bromide (PB) and oxyphenonium (OB) bromide by native and modified cyclodextrins, saccharides, surfactants, organic acids, nonionic and anionic polymers, and other compounds were investigated with ion selective electrodes. The intensity of the bitter taste for a mixed solution of cyclodextrin with PB or OB was quantitatively explained from the observed electromotive force with the following assumptions: the complex and the masking agent do not have any tastes and the bitter taste is independent of other tastes. Sodium dodecyl sulfate reduced the bitter taste remarkably, and this reduction was also explicable on the basis of the same mechanism. Sodium taurodeoxycholate enhanced the bitter taste, because of its strong bitterness, although it formed 1 : 1 complexes with PB and OB. The masking mechanism of saccharides was ascribed to overcoming the weak bitterness of the drug by the strong sweetness. l l-Carrageenan suppressed the bitter taste remarkably. This suppression was ascribed to the binding of PB and OB to l l-carrageenan, the effect of the solution viscosity on the bitter taste, and the covering of the bitter taste receptor by l lcarrageenan. It was suggested that the moderate masking by other polymers was attributable to the effect of the solution viscosity or the receptor covering. Native and modified b b-cyclodextrins, sodium dodecyl sulfate, l l-carrageenan, Tween 20, and sodium carboxymethyl cellulose are good masking agents for the bitter tastes of PB and OB. The drug ion selective electrode is a useful tool for understanding of the masking mechanism of the bitter taste, screening of masking agents, and estimation of appropriate concentrations of the masking agents.

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Section: Methodsmentioning

confidence: 99%

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confidence: 99%

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Masking Mechanisms of Bitter Taste of Drugs Studied with Ion Selective Electrodes

et al. 2006

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“…The similar technique for producing different sensor has been reported previously [14]- [16]. A new construction of the sensor array was deposited on the tip of the Au electrodes.…”

Section: Introductionmentioning

confidence: 99%

A novel Arduino Mega 2560 microcontroller-based electronic tongue for dairy product classification

Tazi¹,

Triyana²,

Siswanta³

2016

AIP Conference Proceedings

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“…(3)(4)(5) Bitterness evaluation studies have been reported for various basic bitter drugs, such as quinine hydrochloride. (6)(7)(8) In addition, we have recently reported a quantitative analytical method for the evaluation of the bitterness of antibiotics such as clarithromycin, (9) Chinese medicine, (10) and bitterness-masked famotidine orally disintegrating tablets. (11) The bitterness prediction method using the taste sensor has already been established in principle in several studies, particularly with regard to basic bitter drugs.…”

Section: Introductionmentioning

confidence: 99%

Bitterness Evaluation of H1-Receptor Antagonists Using a Taste Sensor

2011

Sensors and Materials

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The objective of this study was to evaluate an improved bitterness sensor, which, it is postulated, will allow a more precise and sensitive prediction of the bitterness of active pharmaceutical substances. The bitterness sensor, BT0, has a membrane surface with improved and optimized hydrophobicity, and was developed to enhance the hydrophobic interaction between the membrane and basic bitter substances. The bitterness of eight H 1 -receptor antagonists was measured using a multichannel tastesensing system incorporating sensor BT0. Three variables, relative value (R), change in membrane potential caused by adsorption (CPA) and adsorption ability (CPA/R), were used in the evaluation. For sample solutions of the eight H 1 -receptor antagonists, higher sensor output values of R and CPA were observed with sensor BT0, in comparison with a conventional bitterness sensor, AN0. The higher output values seem to be due to the superior hydrophobic interactions between the BT0 sensor membrane and basic bitter substances, as sensor BT0 also showed higher CPA/R values. The data suggest that sensor BT0 provides a more sensitive bitterness evaluation, being able to detect bitterness in sample solution concentrations as low as 0.01 mg/ml. The eight H 1 -receptor antagonists could be categorized into three groups by principal component analysis using data from sensor BT0. Sensor output from sensor BT0 could be used to discriminate effectively between drugs without the need for performing laborious gustatory sensation tests.

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Quantification of suppression of bitterness using an electronic tongue

Cited by 19 publications

References 0 publications

Masking Mechanisms of Bitter Taste of Drugs Studied with Ion Selective Electrodes

Masking Mechanisms of Bitter Taste of Drugs Studied with Ion Selective Electrodes

A novel Arduino Mega 2560 microcontroller-based electronic tongue for dairy product classification

Bitterness Evaluation of H1-Receptor Antagonists Using a Taste Sensor

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