Quantification of Sodium Alendronate by LC Anion Exchange Using In Line Complexation

Cornelio, Rafael B.; Pavei, Cabral; Verza, Simone Gasparín; Silva, Ana Paula C.; Ortega, George González; Luzia, Alisson B.; Fialho, Sílvia Ligório; Mayorga, Paulo

doi:10.1080/10826070903289027

Search citation statements

Order By: Relevance

Paper Sections

Select...

Introduction1

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2016

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To date, we have only found that Cornelio et al [13] and Ribeiro et al [14] reported the pKa values of alendronate sodium. Both of them cited the data from the Merck Index [15] .…”

Section: Introductionmentioning

confidence: 92%

Determination of pKa values of alendronate sodium in aqueous solution by piecewise linear regression based on acid-base potentiometric titration

Dou

Zhang³

et al. 2016

Journal of Pharmaceutical Analysis

View full text Add to dashboard Cite

As a mono-sodium salt form of alendronic acid, alendronate sodium presents multi-level ionization for the dissociation of its four hydroxyl groups. The dissociation constants of alendronate sodium were determined in this work by studying the piecewise linear relationship between volume of titrant and pH value based on acid-base potentiometric titration reaction. The distribution curves of alendronate sodium were drawn according to the determined pKa values. There were 4 dissociation constants (pKa1=2.43, pKa2=7.55, pKa3=10.80, pKa4=11.99, respectively) of alendronate sodium, and 12 existing forms, of which 4 could be ignored, existing in different pH environments.

show abstract

“…To date, we have only found that Cornelio et al [13] and Ribeiro et al [14] reported the pKa values of alendronate sodium. Both of them cited the data from the Merck Index [15] .…”

Section: Introductionmentioning

confidence: 92%