Quantification of Proteinuria: A Re-evaluation of the Protein/Creatinine Ratio for Elderly Subjects

Mitchell, Scott C.; Sheldon, Thomas A.; Shaw, A.B.

doi:10.1093/ageing/22.6.443

Cited by 36 publications

(32 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This approach, however, is considered by many to be impractical in some circumstances, particularly in the outpatient setting, because of the difficulties associated with obtaining a complete collection. In a study of elderly patients, Mitchell et al (37 ) had to discard Ͼ20% of the samples returned because they were considered to be incomplete; Chitalia et al (34 ) in their study had to discard 10% of the samples received for similar reasons.…”

Section: Discussionmentioning

confidence: 99%

Use of Protein:Creatinine Ratio Measurements on Random Urine Samples for Prediction of Significant Proteinuria: A Systematic Review

2005

View full text Add to dashboard Cite

Background: Proteinuria is recognized as an independent risk factor for cardiovascular and renal disease and as a predictor of end organ damage. The reference test, a 24-h urine protein estimation, is known to be unreliable. A random urine protein:creatinine ratio has been shown to correlate with a 24-h estimation, but it is not clear whether it can be used to reliably predict the presence of significant proteinuria. Methods: We performed a systematic review of the literature on measurement of the protein:creatinine ratio on a random urine compared with the respective 24-h protein excretion. Likelihood ratios were used to determine the ability of a random urine protein:creatinine ratio to predict the presence or absence of proteinuria. Results: Data were extracted from 16 studies investigating proteinuria in several settings; patient groups studied were primarily those with preeclampsia or renal disease. Sensitivities and specificities for the tests ranged between 69% and 96% and 41% and 97%, respectively, whereas the positive and negative predictive values ranged between 46% and 95% and 45% and 98%, respectively. The positive likelihood ratios ranged between 1.8 and 16.5, and the negative likelihood ratios between 0.06 and 0.35. The cumulative negative likelihood ratio for 10 studies on proteinuria in preeclampsia was 0.14 (95% confidence interval, 0.09 -0.24). Conclusion: The protein:creatinine ratio on a random urine specimen provides evidence to "rule out" the

show abstract

Section: Discussionmentioning

confidence: 99%

Use of Protein:Creatinine Ratio Measurements on Random Urine Samples for Prediction of Significant Proteinuria: A Systematic Review

2005

View full text Add to dashboard Cite

show abstract

“…Nevertheless statistically significant values with correlations as high as 0.98 [21] have been reported for ratio of protein: creatinine on a spot urine sample with 24-hr urine collection sample.…”

Section: Discussionmentioning

confidence: 98%

The Relationship between Central Retinal Artery Resistive Index and Measures of Renal Function in Type 2 Diabetes

Ayoola¹,

Soyoye²,

Dawha³

et al. 2016

JDM

View full text Add to dashboard Cite

Background: Renal and ocular vessels are some of the major vessels affected in patients with diabetes, and the involvement of these vessels is independent risk factors for other complications. Hemodynamic flow in arteries may be assessed by using measures such as resistive index, which is a non-invasive measure of the resistance in vessels. The association between retinopathy and nephropathy has been conflicting. This study assessed the relationship between resistive index of the central retinal artery and indices of nephropathy in type 2 diabetes. Method: This cross-sectional study examined 74 Nigerian diabetics who were selected consecutively from the out-patient diabetic clinic of a tertiary hospital in South-West Nigeria. Doppler ultrasound was used to determine the resistive index of the central retinal artery along with the right renal artery. The urinary and serum biochemical parameters were also done to determine the urinary albumin excretion and the glomerular filtration rate. Results: The mean age of participants was 59.62 ± 9.55 years. The mean central retinal artery resistive index (CRARI) was 0.77 ± 0.06, with 65 (87.8%) of the participants having elevated CRARI. There was no statistical difference between patients with normal CRARI and elevated CRARI in respect of their urinary albumin excretion (p = 0.796). There was no significant correlation between CRARI and estimated glomerular filtration rate (r = 0.120; p = 0.309) and right renal artery resistive index (r = 0.068; p = 0.564). Conclusion: This study demonstrates that central retinal artery resistive index (CRARI) may not be a predictor of renal function in diabetics.

show abstract

“…Creatinine concentrations in urine were measured by the Jaffe method (Rock et al, 1986) using the Bayer Axon analyser. Both sE-cadherin and total protein concentrations were adjusted for creatinine concentration and expressed as a sE-cadherin/creatinine index or protein/ creatinine index, respectively, calculated as protein (g l -1 ) × 10 000 divided by creatinine (mmol l -1 ) with units of × 10 g µmol -1 to be in accordance with previous studies (Dyson et al, 1992;Mitchell et al, 1993).…”

Section: Methodsmentioning

confidence: 93%

“…Expressing the urinary results following adjustment for creatinine concentration is probably the more valid reflection of overall sE-cadherin or total protein release as it takes into account the variations in the renal function and hydration state of patients and when evaluated for total protein measurements has been shown to allow the use of single sample analysis as an adequate substitute for 24-h collection and measurement (Dyson et al, 1992;Mitchell et al, 1993). Whether there is a diurnal variation on sE-cadherin concentration, and thus an optimal time for sample collection other than the mid-morning samples used in this study, was not established.…”

Section: Discussionmentioning

confidence: 99%

Urinary concentrations of the soluble adhesion molecule E-cadherin and total protein in patients with bladder cancer

et al. 1999

View full text Add to dashboard Cite

Summary Reduced expression of the adhesion molecule E-cadherin has been associated with increased invasiveness and poorer survival in patients with bladder cancer. We have examined soluble E-cadherin (sE-cadherin) and total protein concentrations in urine from patients with bladder cancer (n = 34), non-neoplastic benign urological diseases (n = 14) and healthy controls (n = 21) to determine their diagnostic and prognostic significance. Soluble E-cadherin concentrations of the cancer group were significantly higher (P < 0.001) than those of the controls but the benign group was not significantly different from either the cancer group or the controls. When sE-cadherin concentrations were adjusted for creatinine, similar but more statistically significant results were obtained and the benign group was significantly elevated compared with the controls (P < 0.01). No differences were apparent between the invasive (pT1-4) and non-invasive (pTa) cancers. Urinary total protein concentrations in the cancer group were significantly higher than the controls (P < 0.001) and the benign group (P < 0.05) although no difference was seen between the benign group and patients with non-invasive (pTa) cancer or between the benign group and controls. When expressed as the protein/creatinine index, results were similar but more statistically significant and a significant difference was seen between invasive and non-invasive cancers (P < 0.01). Only the protein/creatinine index correlated significantly with stage of the tumour (P < 0.01). It is concluded that urinary sE-cadherin measurements are of no greater value than urinary total protein.

show abstract

Quantification of Proteinuria: A Re-evaluation of the Protein/Creatinine Ratio for Elderly Subjects

Cited by 36 publications

References 0 publications

Use of Protein:Creatinine Ratio Measurements on Random Urine Samples for Prediction of Significant Proteinuria: A Systematic Review

Use of Protein:Creatinine Ratio Measurements on Random Urine Samples for Prediction of Significant Proteinuria: A Systematic Review

The Relationship between Central Retinal Artery Resistive Index and Measures of Renal Function in Type 2 Diabetes

Urinary concentrations of the soluble adhesion molecule E-cadherin and total protein in patients with bladder cancer

Contact Info

Product

Resources

About