Abstract:Background
The incidence of zoonotic Plasmodium knowlesi infections in humans is rising in Southeast Asia, leading to clinical studies to monitor the efficacy of antimalarial treatments for knowlesi malaria. One of the key outcomes of antimalarial drug efficacy is parasite clearance. For P. falciparum, parasite clearance is typically estimated using a two-stage method, that involves estimating parasite clearance for individual patients followed by pooling of individual estimates to derive population estimates… Show more
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