Quantification of liver fat content with ultrasonographic attenuation measurement function: Correlation with unenhanced multidimensional computerized tomography

Cerit, Mahi Nur; Şendur, Halit Nahit; Cındıl, Emetullah; Erbaş, Gonca; Yalcin, Mehmet Muhittin; Cerit, Ethem Turgay; Allahverdiyeva, Seriyye; Oktar, Suna Özhan; Yücel, Cem

doi:10.1016/j.clinimag.2020.04.028

Cited by 21 publications

(10 citation statements)

References 41 publications

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“…Recent studies indicated that, when comparing the measurement results of protondensity fat fraction based on magnetic resonance imaging with CAP assessment results based on TE, the former is more effective than CAP in evaluating liver steatosis [20][21][22]. Notably, ATI had a similar diagnostic mechanism in this study [23][24][25].…”

Section: Discussionsupporting

confidence: 54%

Attenuation Imaging with Ultrasound as a Novel Evaluation Method for Liver Steatosis

Hsu

Yen

et al. 2021

JCM

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In recent years, ultrasound attenuation imaging (ATI) has emerged as a new method to detect liver steatosis. However, thus far, no studies have confirmed the clinical utility of this technology. Using a retrospective database analysis of 28 patients with chronic liver disease who underwent ultrasound liver biopsy and ATI, we compared the presence and degree of steatosis measured by ATI with the results obtained through liver biopsy. The area under the receiver operating characteristic curve (AUROC) of the ATI for differentiating between normal and hepatic steatosis was 0.97 (95% confidence interval: 0.83–1.00). The AUROC of the ATI was 0.99 (95% confidence interval: 0.86–1.00) in grade ≥2 liver steatosis and 0.97 (95% confidence interval: 0.82–1.00) in grade 3. ATI showed good consistency and accuracy for the steatosis grading of liver biopsy. Therefore, ATI represents a novel diagnostic measurement to support the diagnosis of liver steatosis in non-invasive clinical practice.

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Section: Discussionsupporting

confidence: 54%

Attenuation Imaging with Ultrasound as a Novel Evaluation Method for Liver Steatosis

Hsu

Yen

et al. 2021

JCM

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“…Despite the paucity of data, the diagnostic performance of ATT and ATI for different steatosis grades is satisfactory. [ 20 , 21 ] Based on RF raw data in QUS, one can obtain and analyze a number of ultrasonic features. A novel machine learning score, QUS score that includes 18 predictive RF features, was developed from a biopsy-proven NAFLD cohort to detect NASH.…”

Section: Non-invasive Assessment Of Hepatic Steatosismentioning

confidence: 99%

“…Among these methods, CAP has been already widely used in clinical practice (see the next section). Despite the paucity of data, the diagnostic performance of ATT and ATI for different steatosis grades is satisfactory [20,21] . Based on RF raw data in QUS, one can obtain and analyze a number of ultrasonic features.…”

Section: Non-invasive Assessment Of Hepatic Steatosismentioning

confidence: 99%

Non-invasive tests of non-alcoholic fatty liver disease

Zhang

Lin

et al. 2022

Chinese Medical Journal

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For the detection of steatosis, quantitative ultrasound imaging techniques have achieved great progress in past years. Magnetic resonance imaging proton density fat fraction is currently the most accurate test to detect hepatic steatosis. Some blood biomarkers correlate with non-alcoholic steatohepatitis, but the accuracy is modest. Regarding liver fibrosis, liver stiffness measurement by transient elastography (TE) has high accuracy and is widely used across the world. Magnetic resonance elastography is marginally better than TE but is limited by its cost and availability. Several blood biomarkers of fibrosis have been used in clinical trials and hold promise for selecting patients for treatment and monitoring treatment response. This article reviews new developments in the non-invasive assessment of non-alcoholic fatty liver disease (NAFLD). Accumulating evidence suggests that various non-invasive tests can be used to diagnose NAFLD, assess its severity, and predict the prognosis. Further studies are needed to determine the role of the tests as monitoring tools. We cannot overemphasize the importance of context in selecting appropriate tests.

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“…The corresponding AUROC was 0.93. The ICC for the interobserver variability of ATT was 0.91 (Cerit et al 2020).…”

Section: Ati Technology (Canon Medical Systems Japan)mentioning

confidence: 94%

Quantification of Liver Fat Content with Ultrasound: A WFUMB Position Paper

Ferraioli

Berzigotti

Barr

et al. 2021

Ultrasound in Medicine & Biology

100

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New ultrasound methods that can be used to quantitatively assess liver fat content have recently been developed. These quantitative ultrasound (QUS) methods are based on the analysis of radiofrequency echoes detected by the transducer, allowing calculation of parameters for quantifying the fat in the liver. In this position paper, after a section dedicated to the importance of quantifying liver steatosis in patients with non-alcoholic fatty liver disease and another section dedicated to the assessment of liver fat with magnetic resonance, the current clinical studies performed using QUS are summarized. These new methods include spectral-based techniques and techniques based on envelope statistics. The spectral-based techniques that have been used in clinical studies are those estimating the attenuation coefficient and those estimating the backscatter coefficient. Clinical studies that have used tools based on the envelope statistics of the backscattered ultrasound are those performed by using the acoustic structure quantification or other parameters derived from it, such as the normalized local variance, and that performed by estimating the speed of sound. Experts' opinions are reported.

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Quantification of liver fat content with ultrasonographic attenuation measurement function: Correlation with unenhanced multidimensional computerized tomography

Cited by 21 publications

References 41 publications

Attenuation Imaging with Ultrasound as a Novel Evaluation Method for Liver Steatosis

Attenuation Imaging with Ultrasound as a Novel Evaluation Method for Liver Steatosis

Non-invasive tests of non-alcoholic fatty liver disease

Quantification of Liver Fat Content with Ultrasound: A WFUMB Position Paper

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