Quantification of lipoproteins by proton nuclear magnetic resonance spectroscopy (1H-NMRS) improves the prediction of cardiac autonomic dysfunction in patients with type 1 diabetes

Nattero-Chávez, L.; Insenser, M.; Amigó, N.; Samino, S.; Martínez-Micaelo, N.; Dorado Avendaño, B.; Quintero Tobar, A.; Escobar-Morreale, H. F.; Luque-Ramírez, M.

doi:10.1007/s40618-023-02289-9

Cited by 1 publication

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“…However, there is growing concern about changes in the concentrations of the apolipoproteins (Apo)B and ApoA-I in children and adolescents with T1DM. Monitoring these apolipoproteins is mainly useful in monitoring cardiovascular risk of T1DM patients who have low-density lipoprotein cholesterol-(LDL-c) and high-level lipoprotein-cholesterol (HDL-c) values within the normal range [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Investigating the Incidence of Dyslipidemia among Brazilian Children and Adolescents Diagnosed with Type 1 Diabetes Mellitus: A Cross-Sectional Study

Fagundes Melo,

Laurindo,

Sloan

et al. 2024

Diseases

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The treatment of Type 1 Diabetes Mellitus (T1DM) has always been a challenge for health professionals in relation to glycemic control. Increased body fat has been related to a worsening of the lipid profile and increased prevalence of dyslipidemia in this population, leading to negative repercussions on the control of cardiovascular risk. We aimed to investigate the distribution of lipid levels and the presence of dyslipidemia in children and adolescents with T1DM. A cross-sectional observational study was conducted with 81 individuals of both sexes (4–19 years) diagnosed with T1DM. Anthropometric and biochemical data were collected, in addition to data on physical activity level, sexual maturation stage, and insulin administration regimen. Lipid levels were categorized as normal, borderline, and elevated, and the presence of dyslipidemia was diagnosed by the presence of one or more altered lipid parameter. We noted a prevalence of dyslipidemia in 65.4% of the participants when considering borderline lipid values. Of those, 23.5% had one altered lipid level, and 42.0% had two or more. The main altered lipid levels were total cholesterol and triglycerides, followed by non-HDL-c. The main factor associated with the worsening of lipid levels was the increase in HbA1c. Sex had a significant effect on the levels of TC, HDL-c, and ApoA-I. The results of this study reinforce the need to monitor lipid profile in children and adolescents with T1DM, as well as the importance of early intervention in treating dyslipidemia, especially in patients with poor glycemic control.

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Section: Introductionmentioning

confidence: 99%