Quantification of Lean Bodyweight

Janmahasatian, Sarayut; Duffull, Stephen B.; Ash, Susan; Ward, Leigh C.; Byrne, Nuala M.; Green, Bruce

doi:10.2165/00003088-200544100-00004

Cited by 747 publications

(654 citation statements)

References 30 publications

Supporting

Mentioning

615

Contrasting

Unclassified

Order By: Relevance

“…Drug dosing based on BMI has been proposed previously but is generally considered to be less accurate than other weight metrics like lean body weight or fat free mass [3]. The authors discuss why they used total body weight and not other weight metrics in this cohort that has few obese patients.…”

Section: Why Is This Study Important Controversial and Thought-provomentioning

confidence: 99%

Amikacin dosing in the ICU: we now know more, but still not enough…

Rosa

Roberts

2014

Intensive Care Med

View full text Add to dashboard Cite

Section: Why Is This Study Important Controversial and Thought-provomentioning

confidence: 99%

Amikacin dosing in the ICU: we now know more, but still not enough…

Rosa

Roberts

2014

Intensive Care Med

View full text Add to dashboard Cite

“…SHINJU OBARA 1) , ISSEI MORIMOTO 2) , YUZO ISEKI 2) , RIEKO OISHI 2) , MIDORI MOGAMI 2) , TSUYOSHI IMAIZUMI 3) , ATSUSHI HOSONO 3) , TAKAHIRO HAKOZAKI 4) , YUKO NAKANO 5) , TSUYOSHI ISOSU 6) and MASAHIRO MURAKAWA …”

Section: [Original Article] the Effect Of Obesity On Dose Of Dexmedetunclassified

The Effect of Obesity on Dose of Dexmedetomidine When Administered With Fentanyl During Postoperative Mechanical Ventilation - Retrospective

Obara

Morimoto

Iseki

et al. 2015

FJMS

View full text Add to dashboard Cite

: We carried out a retrospective investigation on the effect of obesity on dexmedetomidine (DEX) requirements when administered with fentanyl (FEN) during mechanical ventilation after major surgeries. After Institutional Review Board approval, 14 obese patients with a body mass index (BMI) ≥ 30 kg/m 2 and the same number of non -obese patients with similar backgrounds to the obese patients were selected from medical records. Doses of DEX in the first 48 h or until the end of sedation or extubation were calculated for comparison. In addition to comparison of dosing between the groups, associations between total body weight (TBW), BMI, and lean body mass (LBM) values and doses of DEX (mcg/h), between BMI and various indices (i.e., amount per TBW per hour and amount per LBM per hour) of DEX doses, and between above indices of DEX and FEN doses were also examined. There were no significant differences in DEX dose indices between the groups. However, DEX requirements (mcg/h) were significantly increased with TBW (kg) (r = 0.51, P = 0.003), BMI (r = 0.49, P = 0.006) and LBM (kg) (r = 0.42, P = 0.02), which might have enhanced the DEX metabolism with physiological changes with obesity. These findings will be beneficial for future clinical pharmacological analysis of DEX.

show abstract

“…Over 98% of metabolic activity occurs within lean body mass, and anesthesiologists should ensure that they are using the more accurate formulae for calculating LBW that have been developed and work across a wider range of BMI. 66 It is also essential that anesthesia departments provide evidence-based advice on prescribing in severe obesity along with tools to support calculation of LBW (software or paper-based nomograms). In Fig.…”

Section: Intraoperative Carementioning

confidence: 99%