Quantification of In-Stent Restenosis Parameters in Rabbits by Micro-CT

Langheinrich, AC; Zoerb, C; Jajima, J; Lommel, D.; Walker, Gary; Km, Mueller; Ws, Rau; Bohle, RM

doi:10.1055/s-2005-858055

Cited by 11 publications

(7 citation statements)

References 10 publications

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“…The higher bone fills observed by Virolainen et al may be explained by differences in defect type (unicortical vs. transcortical defects), surgical site (tibia vs. cranium) and bone quantification techniques (histomorphometry vs. micro‐CT). Bone quantification by micro‐CT has been shown to represent a reliable and fast approach for imaging and quantifying bone formation (Uchiyama et al 1997; Langheinrich et al 2005; Recker et al 2005; Saparin et al 2005) (Muller et al 1998). In this study, 110 cross‐sectional images were reconstructed and analysed for each cranial defect, thereby producing a better representation of the bone volume than the one extrapolated from a limited number of cross sections analysed in histomorphometric studies.…”

Section: Discussionmentioning

confidence: 99%

Activation of human platelet‐rich plasmas: effect on growth factors release, cell division and in vivo bone formation

Roussy¹,

Duchesne²,

Gagnon³

2007

Clinical Oral Implants Res

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Section: Discussionmentioning

confidence: 99%

Activation of human platelet‐rich plasmas: effect on growth factors release, cell division and in vivo bone formation

Roussy¹,

Duchesne²,

Gagnon³

2007

Clinical Oral Implants Res

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“…Multiple supplemental technologies currently used for investigational purposes or in the clinical setting also have been applied to preclinical models for their application to evaluating next-generation DESs for improved safety and efficacy. These include temporal quantitative en face endothelial analysis via scanning electronic microscopy, 83,128,141 confocal microscopy targeting endothelial and inflammatory markers, 83,128,141 alternative imaging systems (intravascular ultrasound, optical coherence tomography, micro-computed tomography), 27,59,106,183,201 and vasomotor function tests. 80,107 As experience is gained with these technologies, they may well become incorporated into a standard set of valuations in the assessment of DES safety.…”

Section: Assessment Of Des Safetymentioning

confidence: 99%

Preclinical Models of Restenosis and Their Application in the Evaluation of Drug-Eluting Stent Systems

Perkins

2010

Vet Pathol

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Coronary arterial disease (CAD) is the leading cause of death in the United States, the European Union, and Canada. Percutaneous coronary intervention (PCI) has revolutionized the treatment of CAD, and it is the advent of drug-eluting stent (DES) systems that has effectively allayed much of the challenge of restenosis that has plagued the success of PCI through its 30-year history. However, DES systems have not been a panacea: There yet remain the challenges associated with interventions involving bare metallic stents as well as newly arisen concerns related to the application of DES systems. To effectively address these novel and ongoing issues, animal models are relied on both to project the safety and efficacy of endovascular devices and to provide insight into the pathophysiology underlying the vascular response to injury and mechanisms of restenosis. In this review, preclinical models of restenosis are presented, and their application and limitation in the evaluation of device-based interventional technologies for the treatment of CAD are discussed.Keywords restenosis, stent, animal models, coronary artery disease Coronary artery disease (CAD) is the progressive accumulation of atherosclerotic plaque within the lumen of a coronary artery, with the typical result being luminal narrowing, reduced compliance of the vessel wall, and either a gradual reduction or a dramatic and sudden loss of blood supply to the myocardium. It is the leading cause of death in the United States, the European Union, and Canada, singly accounting for the death of 1 in 5 Americans. 117,185 In treatment options for symptomatic CAD, percutaneous coronary intervention (PCI) is the foremost modality, being based on the nonsurgical placement of a bare metallic scaffold, or stent, to prop open the artery to regain patency. However, there are drawbacks to coronary stenting, with restenosis being the Achilles' heel, accounting for a rate of failure up to 15 to 25%.18,124 Drug-eluting stents (DESs) have revolutionized PCI by effectively reducing restenosis rates to the single digits over standard bare metallic stents.DES systems combine mechanical and pharmacological approaches to assuage one or more events in the cascade that results in restenosis. These combination products consist of an intravascular scaffolding device that presents or releases single or multiple bioactive agents or pharmaceuticals into the bloodstream and arterial wall. Traditional DESs have consisted of a platform (stent), a carrier (usually a polymer), and an antirestenotic agent that is delivered locally to avert the need for high, systemically administered doses. The fundamental goal of the DES is to restore lumen patency while curtailing the diseased vessel's innate and often exuberant response to the implanted foreign material (stent) and to stent-induced injury. Despite the success of current DESs at achieving these goals, concerns have surfaced with their accruing clinical use. Such concerns pertain to vascular healing and late stent thrombosis, biocompat...

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“…Micro-CT is one of the potential tools for 3-D reconstruction of the small implants and converting STL files for importing computational simulations due to the high spatial resolution. Jiang et al (2000) used it for trabecular geometry, and Langheinrich et al (2005) used it as the diagnosis method after stenting into stenosis. Cheema et al (2006) delineated adventitial microvessel using micro-CT. He et al (2006) applied micro-CT for measuring blood flow of rat as an angiography.…”

Section: Introductionmentioning

confidence: 99%

Three-Dimensional Reconstruction of a Cerebral Stent using Micro-CT for Computational Simulation

Ohta

Nakayama

et al. 2007

Journal of Intelligent Material Systems and Structures

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The surface geometry of an intracranial stent (ICS) for a cerebral aneurysm is reconstructed by using micro-CT to import computational fluid simulations. The reconstructed stent with STL format is composed of 170,948 triangles with 0.04mm spatial resolutions. The boundary condition of the surface is clear without any reflection effects by X-ray introduced into the stainless steel stent. The computational simulations of blood flow with small implants, such as a stent or coil will be a designable way to control blood flow in/on a cerebral aneurysm and repair the disease. Micro-CT has a possibility of detecting the 3-D geometry of a small implant, such as ICS and may be useful to 3-D reconstruction and integration to computational simulation.

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Quantification of In-Stent Restenosis Parameters in Rabbits by Micro-CT

Abstract: Micro-CT is feasible for quantitative information about restenosis following balloon angioplasty and stent implantation and has the potential to become a standard technique in many laboratories which will augment serial histology as the reference method for ex-vivo studies of restenosis.

Cited by 11 publications

References 10 publications

Activation of human platelet‐rich plasmas: effect on growth factors release, cell division and in vivo bone formation

Activation of human platelet‐rich plasmas: effect on growth factors release, cell division and in vivo bone formation

Preclinical Models of Restenosis and Their Application in the Evaluation of Drug-Eluting Stent Systems

Three-Dimensional Reconstruction of a Cerebral Stent using Micro-CT for Computational Simulation

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