Quantification of Immunity Status of Dabur Chyawanprash - A Review Part- 2 (Clinical Studies)

Sastry, J. L. N.; Gupta, Arun; Brindavanam, N. B.; Kanjilal, Satyajyoti; Kumar, Sumit; Setia, M. S.; Vedula, Sasibhushan; Srivastava, Ruchi

doi:10.15373/2249555x/mar2014/61

Cited by 12 publications

(4 citation statements)

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“…NK cell activity was significantly increased by Chyawanprash treatment. On treating dendritic cells with Chyawanprash, there was a significant increase in immunity marker levels as well as phagocytic activity that proves its immunomodulatory activity (Sastry et al, 2011).…”

Section: Chyawanprashmentioning

confidence: 93%

Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical Research

et al. 2021

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The cases of COVID-19 are still increasing day-by-day worldwide, even after a year of its first occurrence in Wuhan city of China. The spreading of SARS-CoV-2 infection is very fast and different from other SARS-CoV infections possibly due to structural differences in S proteins. The patients with severe diseases may die due to acute respiratory distress syndrome (ARDS) caused by systemic inflammatory reactions due to the excessive release of pro-inflammatory cytokines and chemokines by the immune effector cells. In India too, it is spreading very rapidly, although the case fatality rate is below 1.50% (https://www.statista.com), which is markedly less than in other countries, despite the dense population and minimal health infrastructure in rural areas. This may be due to the routine use of many immunomodulator medicinal plants and traditional AYUSH formulations by the Indian people. This communication reviews the AYUSH recommended formulations and their ingredients, routinely used medicinal plants and formulations by Indian population as well as other promising Indian medicinal plants, which can be tested against COVID-19. Special emphasis is placed on Indian medicinal plants reported for antiviral, immunomodulatory and anti-allergic/anti-inflammatory activities and they are categorized for prioritization in research on the basis of earlier reports. The traditional AYUSH medicines currently under clinical trials against COVID-19 are also discussed as well as furtherance of pre-clinical and clinical testing of the potential traditional medicines against COVID-19 and SARS-CoV-2. The results of the clinical studies on AYUSH drugs will guide the policymakers from the AYUSH systems of medicines to maneuver their policies for public health, provide information to the global scientific community and could form a platform for collaborative studies at national and global levels. It is thereby suggested that promising AYUSH formulations and Indian medicinal plants must be investigated on a priority basis to solve the current crisis.

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Section: Chyawanprashmentioning

confidence: 93%

Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical Research

et al. 2021

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“…The augmented immunity marker levels (TNF-α, IL-1β, and MIP1α), as well as enhancement of NK cells and phagocytic activity support the immunomodulatory properties of CP [117]. Clinical studies also support the immune-booster role of CP as demonstrated by reduced disease symptoms of seasonal influences, modulated IgE and immunity markers C3 and C4 levels, improved pulmonary functions, decreased cortisol levels, and increased quality of life (QoL) [118].…”

Section: Health Benefitsmentioning

confidence: 99%

Chyawanprash: A Traditional Indian Bioactive Health Supplement

et al. 2019

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Chyawanprash (CP) is an Ayurvedic health supplement which is made up of a super-concentrated blend of nutrient-rich herbs and minerals. It is meant to restore drained reserves of life force (ojas) and to preserve strength, stamina, and vitality, while stalling the course of aging. Chyawanprash is formulated by processing around 50 medicinal herbs and their extracts, including the prime ingredient, Amla (Indian gooseberry), which is the world’s richest source of vitamin C. Chyawanprash preparation involves preparing a decoction of herbs, followed by dried extract preparation, subsequent mixture with honey, and addition of aromatic herb powders (namely clove, cardamom, and cinnamon) as standard. The finished product has a fruit jam-like consistency, and a sweet, sour, and spicy flavor. Scientific exploration of CP is warranted to understand its therapeutic efficacy. Scattered information exploring the therapeutic potential of CP is available, and there is a need to assemble it. Thus, an effort was made to compile the scattered information from ancient Ayurvedic texts and treatises, along with ethnobotanical, ethnopharmacological, and scientifically validated literature, that highlight the role of CP in therapeutics. Citations relevant to the topic were screened.

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“…As Chywanprashavleha is an Ayurvedic propriety medicine not much work has been done on it overseas. In India a randomized clinical trial on 627 children by Gupta A. et.al [53] showed that regular use of Chywanprashavleha reduces the incidence of immunity related illness more than half as compared to the control. Chywanprashavleha also showed better percentage improvement in strength, stamina, energy levels, physical fitness, and quality of life in children.…”

Section: Anti-viral Activitymentioning

confidence: 99%

Antiviral with Immune Booster Therapy: Current concept for clinical care in Covid-19

Kajaria

2023

J Ayurveda Integr Med Sci

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Objective: Objective of the article is to provide a brief overview of novel corona virus, discussing the role of immunity in the pathogenesis, analyzing the comparative efficacy of anti-viral vs. immune- enhancer medicines and propose a stepwise treatment methodology of both these groups of herbs for prevention as well as management of COVID-19. Data Source: Ayurvedic texts including Brihatatrayi (Charaka Samhita, Sushruta Samhita & Astanga Hridyam), Laghutrayi, Nighantus, published article in PubMed, Scopus, Science Direct, Google Scholar, AYUSH Portal, etc., were thoroughly searched for the compilation of information. Review method: Narrative and systematic methods for reviewing the literature and related published article was used Discussion: There is yet no proven drug for the treatment of COVID-19 and therefore presently medicines having substantial evidences are use for the treatment of COVID-19 on trial basis to assess best possible treatment. In this direction, this article provides a framework of treatment methodology according to Ayurveda for the prevention as well as management of COVID-19. Conclusion: The article provides details of anti-viral medicines and immune-boosting medicines described in Ayurveda and give the logistical approach for their sequential use to manage the disease.

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Quantification of Immunity Status of Dabur Chyawanprash - A Review Part- 2 (Clinical Studies)

Cited by 12 publications

References 0 publications

Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical Research

Indian Medicinal Plants and Formulations and Their Potential Against COVID-19–Preclinical and Clinical Research

Chyawanprash: A Traditional Indian Bioactive Health Supplement

Antiviral with Immune Booster Therapy: Current concept for clinical care in Covid-19

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