Quantification of I-123-meta-iodobenzylguanidine Heart-to-Mediastinum Ratios: Not So Simple After All

Slomka, Piotr J.; Mehta, Puja K.; Germano, Guido; Berman, Daniel S.

doi:10.1007/s12350-014-9943-z

Cited by 11 publications

(7 citation statements)

References 30 publications

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“…The impact of these variations in collimators on the HMR is best illustrated by a Japanese multicenter phantom study [16]. In this study variations in the phantom identified an HMR of 1.6 for the same LE high-resolution (LEHR) collimators which ranged in measured values between 1.50 and 1.74 [26]. …”

Section: What Should Be Standardized?mentioning

confidence: 99%

Standardization of 123I-meta-iodobenzylguanidine myocardial sympathetic activity imaging: phantom calibration and clinical applications

Nakajima

Verschure

Okuda

et al. 2017

Clin Transl Imaging

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PurposeMyocardial sympathetic imaging with 123I-meta-iodobenzylguanidine (123I-mIBG) has gained clinical momentum. Although the need for standardization of 123I-mIBG myocardial uptake has been recognized, the availability of practical clinical standardization approaches is limited. The need for standardization includes the heart-to-mediastinum ratio (HMR) and washout rate with planar imaging, and myocardial defect scoring with single-photon emission computed tomography (SPECT).MethodsThe planar HMR shows considerable variation due to differences in collimator design. These camera–collimator differences can be overcome by cross-calibration phantom experiments. The principles of these cross-calibration phantom experiments are summarized in this article. 123I-mIBG SPECT databases were compiled by Japanese Society of Nuclear Medicine working group. Literature was searched based on the words “123I-mIBG quantification method”, “standardization”, “heart-to-mediastinum ratio”, and its application to “risk model”.ResultsCalibration phantom experiments have been successfully performed in Japan and Europe. The benefit of these cross-calibration phantom experiments is that variation in the HMR between institutions is minimized including low-energy, low–medium-energy and medium-energy collimators. The use of myocardial 123I-mIBG SPECT can be standardized using 123I-mIBG normal databases as a basis for quantitative evaluation. This standardization method can be applied in cardiac event prediction models.ConclusionStandardization of myocardial 123I-mIBG outcome parameters may facilitate a universal implementation of myocardial 123I-mIBG scintigraphy.

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Section: What Should Be Standardized?mentioning

confidence: 99%

Standardization of 123I-meta-iodobenzylguanidine myocardial sympathetic activity imaging: phantom calibration and clinical applications

Nakajima

Verschure

Okuda

et al. 2017

Clin Transl Imaging

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“…Recent reviews have summarized the mechanism by which I-123 MIBG is taken up by the nerve terminal, the utility of this agent, and the technical aspects of its imaging. [24][25][26][27] One of the strengths of the current study by dos Santos 28 is that all of the subjects were relatively young (mean age of 16), when identification of early anthracycline-induced cardiomyopathy would be most critical. The subjects were a median of 5.3 years out from their chemotherapy.…”

Section: See Related Article Pp 256-264mentioning

confidence: 99%

Anthracycline-induced cardiomyopathy: The search continues

Kim

Bergmann

2017

Journal of Nuclear Cardiology

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“…To overcome this issue, it has been suggested that the H/M ratio threshold of 1.6 reported with the LEHR collimator should be converted to 2.0 for an institution in which the ME general-purpose collimator is used [33]. However, differences in the software used for analysis and variability in defining the regions of interest for mediastinum or heart may impact the result observed, especially in subjects with abnormal studies [34]. …”

Section: Image Acquisitionmentioning

confidence: 99%

123I-Metaiodobenzylguanidine cardiac innervation imaging: methods and interpretation

Pellegrino

Piscopo

Petretta

et al. 2015

Clin Transl Imaging

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The heart is richly innervated with sympathetic and parasympathetic fibers that work in conjunction with norepinephrine to accurately preserve hemodynamic and electrophysiological stability at rest and during periods of increased cardiovascular demand. Imaging of the cardiac sympathetic system is an area of active investigation in a wide variety of conditions, such as heart failure, arrhythmias, and ischemic heart diseases, providing an independent ability to risk stratify and a potential guide for improving patient management. 123 I-metaiodobenzylguanidine (MIBG), an analog of the false neurotransmitter guanethidine, represents the most widely studied tracer for imaging of the cardiac autonomic system. Myocardial scintigraphy with 123 I-MIBG is widely used in Europe and Japan but to date there is no established standard for tracer administration, imaging acquisition, and interpretation. We discuss the current literature regarding methods and interpretation of 123 I-MIBG cardiac innervation imaging.

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Quantification of I-123-meta-iodobenzylguanidine Heart-to-Mediastinum Ratios: Not So Simple After All

Cited by 11 publications

References 30 publications

Standardization of 123I-meta-iodobenzylguanidine myocardial sympathetic activity imaging: phantom calibration and clinical applications

Standardization of 123I-meta-iodobenzylguanidine myocardial sympathetic activity imaging: phantom calibration and clinical applications

Anthracycline-induced cardiomyopathy: The search continues

123I-Metaiodobenzylguanidine cardiac innervation imaging: methods and interpretation

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