Quantification of human bone microarchitecture damage in press-fit femoral knee implantation using HR-pQCT and digital volume correlation

Rapagna, Sophie; Berahmani, Sanaz; Wyers, Caroline E.; Bergh, Joop van den; Reynolds, Karen; Tozzi, Gianluca; Janssen, Dennis; Perilli, Egon

doi:10.1016/j.jmbbm.2019.04.054

Cited by 27 publications

(9 citation statements)

References 34 publications

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“…The technique enabled non-destructive mechanical evaluation of the tissue and ultimately provided 3D strain maps for the first time [ 14 ]. In the last 20 years, DVC has provided the opportunity to characterise mechanics such as: strain across the osteochondral interface [ 15 , 16 ] examining ex vivo explants to quantify bone-implant micromotion [ 17 ], bone cement implantation [ 18 ] and cementless implant press-fitting [ 19 ]. Following sample retrieval, ex vivo analysis has taken place on bone-biomaterial systems for tissue regeneration [ 20 ], the stability of bone-screw systems [ 21 ] and newly formed bone tissue [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Exploratory Full-Field Mechanical Analysis across the Osteochondral Tissue—Biomaterial Interface in an Ovine Model

et al. 2020

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Osteochondral injuries are increasingly prevalent, yet success in articular cartilage regeneration remains elusive, necessitating the development of new surgical interventions and novel medical devices. As part of device development, animal models are an important milestone in illustrating functionality of novel implants. Inspection of the tissue-biomaterial system is vital to understand and predict load-sharing capacity, fixation mechanics and micromotion, none of which are directly captured by traditional post-mortem techniques. This study aims to characterize the localised mechanics of an ex vivo ovine osteochondral tissue–biomaterial system extracted following six weeks in vivo testing, utilising laboratory micro-computed tomography, in situ loading and digital volume correlation. Herein, the full-field displacement and strain distributions were visualised across the interface of the system components, including newly formed tissue. The results from this exploratory study suggest that implant micromotion in respect to the surrounding tissue could be visualised in 3D across multiple loading steps. The methodology provides a non-destructive means to assess device performance holistically, informing device design to improve osteochondral regeneration strategies.

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Section: Introductionmentioning

confidence: 99%

Exploratory Full-Field Mechanical Analysis across the Osteochondral Tissue—Biomaterial Interface in an Ovine Model

et al. 2020

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“…Research utilising DVC for soft tissue applications is in comparative infancy [ 16 , 17 , 18 ]. Use of DVC for medical implants has solely focused on applications in bone, namely to measure implant micromotion [ 19 ], bone damage during device implantation [ 20 ] and strain across the interface of tissue–biomaterial systems [ 21 ]. Two studies utilised DVC to examine the mechanics of scaffold implants, again only for bone repair applications [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Quantifying 3D Strain in Scaffold Implants for Regenerative Medicine

et al. 2020

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Regenerative medicine solutions require thoughtful design to elicit the intended biological response. This includes the biomechanical stimulus to generate an appropriate strain in the scaffold and surrounding tissue to drive cell lineage to the desired tissue. To provide appropriate strain on a local level, new generations of scaffolds often involve anisotropic spatially graded mechanical properties that cannot be characterised with traditional materials testing equipment. Volumetric examination is possible with three-dimensional (3D) imaging, in situ loading and digital volume correlation (DVC). Micro-CT and DVC were utilised in this study on two sizes of 3D-printed inorganic/organic hybrid scaffolds (n = 2 and n = 4) with a repeating homogenous structure intended for cartilage regeneration. Deformation was observed with a spatial resolution of under 200 µm whilst maintaining displacement random errors of 0.97 µm, strain systematic errors of 0.17% and strain random errors of 0.031%. Digital image correlation (DIC) provided an analysis of the external surfaces whilst DVC enabled localised strain concentrations to be examined throughout the full 3D volume. Strain values derived using DVC correlated well against manually calculated ground-truth measurements (R2 = 0.98, n = 8). The technique ensures the full 3D micro-mechanical environment experienced by cells is intimately considered, enabling future studies to further examine scaffold designs for regenerative medicine.

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“…This technique has been employed to evaluate full-field internal deformations in bone structures at the organ and tissue levels [ 17 , 18 ]. The DVC approach has also been used to study the effect of biomaterials and implants on the deformation of the bone tissue [ 19 , 20 , 21 ]. It has proved an auspicious approach for measuring internal strains of bone under various loading conditions and offers a crucial method for validation of finite element (FE) models of bone [ 22 , 23 , 24 , 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Heterogeneous Strain Distribution in the Subchondral Bone of Human Osteoarthritic Femoral Heads, Measured with Digital Volume Correlation

et al. 2020

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Osteoarthritis (OA) is a chronic disease, affecting approximately one third of people over the age of 45. Whilst the etiology and pathogenesis of the disease are still not well understood, mechanics play an important role in both the initiation and progression of osteoarthritis. In this study, we demonstrate the application of stepwise compression, combined with microCT imaging and digital volume correlation (DVC) to measure and evaluate full-field strain distributions within osteoarthritic femoral heads under uniaxial compression. A comprehensive analysis showed that the microstructural features inherent in OA bone did not affect the level of uncertainties associated with the applied methods. The results illustrate the localization of strains at the loading surface as well as in areas of low bone volume fraction and subchondral cysts. Trabecular thickness and connectivity density were identified as the only microstructural parameters with any association to the magnitude of local strain measured at apparent yield strain or the volume of bone exceeding yield strain. This work demonstrates a novel approach to evaluating the mechanical properties of the whole human femoral head in case of severe OA.

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Quantification of human bone microarchitecture damage in press-fit femoral knee implantation using HR-pQCT and digital volume correlation

Cited by 27 publications

References 34 publications

Exploratory Full-Field Mechanical Analysis across the Osteochondral Tissue—Biomaterial Interface in an Ovine Model

Exploratory Full-Field Mechanical Analysis across the Osteochondral Tissue—Biomaterial Interface in an Ovine Model

Quantifying 3D Strain in Scaffold Implants for Regenerative Medicine

Heterogeneous Strain Distribution in the Subchondral Bone of Human Osteoarthritic Femoral Heads, Measured with Digital Volume Correlation

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