Quantification of hip effusion-synovitis and its cross-sectional and longitudinal associations with hip pain, MRI findings and early radiographic hip OA

Abstract

Background: Hip effusion-synovitis may be relevant to osteoarthritis (OA) but is of uncertain etiology. The aim of this study was to describe the cross-sectional and longitudinal associations of hip effusion-synovitis with clinical and structural risk factors of OA in older adults. Methods: One hundred ninety-six subjects from the Tasmanian Older Adult Cohort (TASOAC) study with a right hip STIR (Short T1 Inversion Recovery) Magnetic Resonance Imaging (MRI) on two occasions were included. Hip effusion-synovitis CSA (cm 2) was assessed quantitatively. Hip pain was determined by WOMAC (Western Ontario and McMaster Universities Osteoarthritis) while hip bone marrow lesions (BMLs), cartilage defects (femoral and/or acetabular) and high cartilage signal were assessed on MRI. Joint space narrowing (0-3) and osteophytes (0-3) were measured on x-ray using Altman's atlas. Results: Of 196 subjects, 32% (n = 63) had no or a small hip effusion-synovitis while 68% (n = 133) subjects had a moderate or large hip effusion-synovitis. Both groups were similar but those with moderate or large hip effusionsynovitis were older, had higher BMI and more hip pain. Cross-sectionally, hip effusion-synovitis at multiple sites was associated with presence of hip pain [Prevalence ratio (PR):1.42 95%CI:1.05,1.93], but not with severity of hip pain. Furthermore, hip effusion-synovitis size associated with femoral defect (βeta:0.32 95%CI:0.08,0.56). Longitudinally, and incident hip cartilage defect (PR: 2.23 95%CI:1.00, 4.97) were associated with an increase in hip effusion-synovitis CSA. Furthermore, independent of presence of effusion-synovitis, hip BMLs predicted incident (PR:

Selumetinib - a potential small molecule inhibitor for osteoarthritis treatment

“…OA is a widespread and disabling disease characterized by cartilage degeneration, subchondral osteosclerosis, and synovitis (A et al, 2011, Ahedi et al, 2020 ). The necroptosis of chondrocytes and the degradation of the ECM together contribute to the development of osteoarthritis ( Cheng et al, 2021 ; Li et al, 2021 ).…”

A prospective cohort study on cam morphology and its role in progression of osteoarthritis

“…A set of sagittal images was obtained with a slice thickness of 3.5 mm and an inter‐slice gap of 1.5 mm using a STIR‐weighted, fat saturation, 2‐dimensional fast spin‐echo sequence was obtained 14 . Using Osiris X software (University of Geneva) imaging markers such as bone marrow lesions (BMLs), 17 high cartilage signal, 17 hip cartilage defects 18 and hip effusion‐synovitis 19 were assessed.…”

“…The observer (HGA) manually selected the magnetic resonance slice with the largest effusion‐synovitis and determined the maximum cross‐sectional area of the bright region by manually drawing contours around the outer edges. In a reliability study of 40 subjects with repeated measurements after 4 weeks, the intra‐rater agreement (kappa) for the presence of hip effusion‐synovitis was 0.84 19 …”

“…In a reliability study of 40 subjects with repeated measurements after 4 weeks, the intra-rater agreement (kappa) for the presence of hip effusion-synovitis was 0.84. 19…”

Osteoarthritis year in review 2021: imaging

“…One study quantitatively assessed hip effusion-synovitis cross-sectional area on hundred ninety-six older adults 18 . Overall, there was no association between hip effusion-synovitis and hip pain.…”