Quantification of hepatic and renal cortical echogenicity in clinically normal cats

Drost, Wm Tod; Henry, Goecke; Meinkoth, James H.; Woods, J. Paul; Lehenbauer, Terry W.

doi:10.2460/ajvr.2000.61.1016

Cited by 46 publications

(58 citation statements)

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“…All previous in-vivo veterinary studies reported in the literature to objectively evaluate renal cortical echogenicity were performed in healthy animals [4–6]. These papers presented renal cortical echogenicity assessed by means of a tissue equivalent phantom [4] or in comparison to other organs [5, 6].…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…These papers presented renal cortical echogenicity assessed by means of a tissue equivalent phantom [4] or in comparison to other organs [5, 6]. It is the authors’ opinion that both these approaches have some limitations; comparison with a tissue equivalent phantom is a complicated and time consuming procedure [4]. On the other hand, comparison with other organs is unreliable because: 1) renal cortical echogenicity in dogs with normal renal function is reported to be hypo, iso- or hyper-echoic to the liver [5]; 2) it assumes the spleen or the liver to be normal.…”

Section: Discussionmentioning

confidence: 99%

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Relationship of diagnostic accuracy of renal cortical echogenicity with renal histopathology in dogs and cats, a quantitative study

et al. 2016

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BackgroundRenal cortical echogenicity is routinely evaluated during ultrasonographic investigation of the kidneys. Both in dog and cat previous ex-vivo studies have revealed a poor correlation between renal echogenicity and corresponding lesions. The aim of this study was to establish the in-vivo relationship between renal cortical echogenicity and renal histopathology.ResultsThirty-eight dogs and fifteen cats euthanized for critical medical conditions were included in the study. Ultrasonographic images of both kidneys were acquired ante mortem at standardized ultrasonographic settings. The echogenicity was quantified by means of Mean Gray Value (MGV) of the renal cortex measured with ImageJ. A complete histopathological examination of both kidneys was performed. Five kidneys were excluded because histopathology revealed neoplastic lesions. Only samples affected by tubular atrophy showed statistically different values in dog, and histopathology explained 13% of the total variance. MGV was not correlated neither to the degeneration nor to the inflammation scores. However, significant differences were identified between mildly and severely degenerated samples. Overall, the classification efficiency of MGV to detect renal lesions was poor with a sensitivity of 39% and a specificity of 86%.In cats, samples affected by both tubular vacuolar degeneration and interstitial nephritis were statistically different and histopathology explained 44% of the total variance. A linear correlation was evident between degeneration and MGV, whereas no correlation with inflammation was found. Statistically significant differences were evident only between normal and severely degenerated samples with a sensitivity of 54.17% and a specificity of 83.3% and MGV resulted scarce to discriminate renal lesions in this species.ConclusionsRenal cortical echogenicity shows low relevance in detecting chronic renal disease in dog whereas it results worth to identify severe renal damage in cat.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Relationship of diagnostic accuracy of renal cortical echogenicity with renal histopathology in dogs and cats, a quantitative study

et al. 2016

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“…Em gatos, foi realizado um estudo para determinar de maneira quantitativa a ecogenicidade do fígado e cortical renal em pacientes clinicamente normais, utilizando análise de histograma. Conclui-se que os gatos normais possuem uma maior ecogenicidade da cortical em relação fígado; e apesar deste estudo ter demonstrado que a ecogenicidade do fígado e córtex renal em gatos pode ser quantificada, porém nem a avaliação ultrassonográfica qualitativa nem a quantitativa substituem a avaliação histológica (DROST et al, 2000). Nefrite intersticial e glomerular, necrose ou nefrose tubular aguda, (causado por etilenoglicol, uvas em cães e lírio em gatos), estágio terminal da doença renal e nefrocalcinose podem causar hiperecogenicidade da cortical (WALTER et al, 1987b;WALTER et al, 1988;BARR et al, 1989;BECK;SLOCOMBE, 1991;FORREST et al, 1998;EUBIG et al, 2005 (WALTER et al, 1987b).…”

Section: Ultrassonografia Renal Modo Bunclassified

“…Deve-se lembrar que a espécie felina pode apresentar vacúolos de gordura no epitélio tubular proximal causando elevação da ecogenicidade da cortical (KONDE, 1989;YEAGER;ANDERSON, 1989;DROST, 2000 Morrow et al (1996) encontrou uma média do IR de 0,61 ± 0,06 para a espécie canina, similarmente ao que foi publicado anteriormente por Nyland et al (1993), que encontrou valor médio do IR de 0,62 ± 0,05. No entanto, é sugerido valor máximo de 0.70 tanto para gatos quanto para cães (MORROW et al, 1996), o que é também o limite utilizado em medicina humana (PLATT et al, 1990).…”

Section: Análise De Correlação Entre As Medidas De Tamanho Do Rim Esqunclassified

O exame ultrassonográfico modo B, Doppler colorido e pulsado na avaliação da doença renal crônica em felinos

Saraiva¹

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Doença renal crônica é uma afecção comum em cães e gatos, especialmente em gatos senis, e importante causa de morbidade e mortalidade. Além da idade avançada, fatores como alterações congênitas, alimentação inadequada, utilização de drogas nefrotóxicas, intoxicações e doenças infecciosas predispõem às lesões do parênquima renal. Em felinos a descrição histopatológica mais frequente é a nefrite tubulointersticial difusa. Independente da causa do dano ao néfron, a doença renal crônica é uma afecção irreversível e geralmente progressiva. Este estudo teve por objetivo realizar uma análise da contribuição da ultrassonografia utilizando-se o modo B e Doppler colorido e pulsado para o diagnóstico e estagiamento da doença renal crônica em 45 felinos. Sendo 16 do grupo controle, felinos que não portavam manifestações clínicas relacionadas ao sistema urinário, apresentavam concentração sérica de creatinina inferior a 1,6mg/dL; quatro do estágio 1, felinos com taxas de creatinina sérica inferior a 1,6mg/dL com alterações ultrassonográficas; 17 do estágio II, felinos com taxas de creatinina 1,6 a 2,8mg/dL; oito do estágio III / IV, felinos com taxa de creatinina sérica de 2,9 a 5,0mg/dL agrupados aos felinos com taxa de creatinina sérica acima de 5,0mg/dL. Os rins foram avaliados ultrassonograficamente por meio das características: ecogenicidade da cortical, regularidade de contorno e definição corticomedular no modo B; comprimento, largura e altura nos cortes Doppler and spectral Doppler. Sixteen presenting no manifestation of urinary disease and serum creatinine levels less than 1,6mg/dL served at control group; four cats represented stage I, with serum creatinine levels less than 1,6mg/dL and ultrasonographic changes; 17 cats represented stage II, with serum creatinine levels between 1,6 and 2,8mg/dL; eight cats represented stage III/IV, with serum creatinine levels between 2,9 e 5,0mg/dL, grouped with the felines with serum creatinine levels above 5,0mg/dL. The kidneys underwent an ultrasonographic examination observing: cortical echogenicity, regularity of the contour and corticomedullary definition in the B mode; length, width and height in the longitudinal, transverse and dorsal planes in the B mode; filling of the interlobars, arcuate and interlobulars arteries by the color Doppler; and resistive index of the intrarenal vessels using the pulsed Doppler. The ratio between the length of the kidney and the luminal diameter of the aorta in normal felines and in felines with kidney disease was established. The increase in echogenicity of the cortex showed to be a relevant characteristic to be considered in the ultrasonographic evaluation of chronic kidney disease. The color Doppler showed to be an important tool in the diagnosis of the chronic kidney disease, especially when the alterations in the B mode weren't expressive. The resistive index did not present itself above of the normal limits in the initial stages of the chronic kidney disease, suggesting it's uselessness as a predictor of the chronic kidney disease. Cha...

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Ultrasonography of the Urinary Tract

Hecht¹,

Henry²

2011

Nephrology and Urology of Small Animals

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Quantification of hepatic and renal cortical echogenicity in clinically normal cats

Abstract: Quantitative determination of hepatic and renal cortical echogenicity in cats is feasible, using histogram analysis, and may be useful for early detection of diffuse parenchymal disease and for serially evaluating disease progression.

Cited by 46 publications

References 25 publications

Relationship of diagnostic accuracy of renal cortical echogenicity with renal histopathology in dogs and cats, a quantitative study

Relationship of diagnostic accuracy of renal cortical echogenicity with renal histopathology in dogs and cats, a quantitative study

O exame ultrassonográfico modo B, Doppler colorido e pulsado na avaliação da doença renal crônica em felinos

Ultrasonography of the Urinary Tract

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