Abstract:Furocoumarins are secondary metabolites that occur in various plant species used as ingredients in fragrances and cosmetics. Those compounds have received an increased interest in those matrices since they are known to induce photosensitization and to have potential carcinogenic, mutagenic and reprotoxic effects. To date, there are no restricted limits regarding these compounds; however, some committees proposed following seven targeted compounds at low level concentration in finished cosmetic products (≤1 mg/… Show more
“…In particular, a careful investigation of the scientific literature on the subject shows how HPLC coupled to different detection systems is the most exploited analytical strategy for this purpose. As far as the identification of new compounds and qualitative profiling is concerned, the most frequently applied detection is represented by medium and high resolution mass spectrometry (MS, MS/MS, and HRMS) [38,50,58,59,70,73,76,79,81,84,85,86,87,88,89,90,91,92,93,94,95,96], while for quantitative targeted purposes, other detection systems have proved to be useful, such as ultraviolet (UV), diode array (DAD) [38,53,67,77,81,88,90,97], and fluorescence detection (FLD) [89,98,99,100]. The high selectivity provided by MS is essential for isomeric compounds, such as bergapten and xanthotoxins.…”
Section: Analysis Of Furanocoumarins In Plantsmentioning
The aim of this work is to provide a critical review of plant furanocoumarins from different points of view, including their chemistry and biosynthetic pathways to their extraction, analysis, and synthesis, to the main biological activities found for these active compounds, in order to highlight their potential within pharmaceutical science. The limits and the possible improvements needed for research involving these molecules are also highlighted and discussed.
“…In particular, a careful investigation of the scientific literature on the subject shows how HPLC coupled to different detection systems is the most exploited analytical strategy for this purpose. As far as the identification of new compounds and qualitative profiling is concerned, the most frequently applied detection is represented by medium and high resolution mass spectrometry (MS, MS/MS, and HRMS) [38,50,58,59,70,73,76,79,81,84,85,86,87,88,89,90,91,92,93,94,95,96], while for quantitative targeted purposes, other detection systems have proved to be useful, such as ultraviolet (UV), diode array (DAD) [38,53,67,77,81,88,90,97], and fluorescence detection (FLD) [89,98,99,100]. The high selectivity provided by MS is essential for isomeric compounds, such as bergapten and xanthotoxins.…”
Section: Analysis Of Furanocoumarins In Plantsmentioning
The aim of this work is to provide a critical review of plant furanocoumarins from different points of view, including their chemistry and biosynthetic pathways to their extraction, analysis, and synthesis, to the main biological activities found for these active compounds, in order to highlight their potential within pharmaceutical science. The limits and the possible improvements needed for research involving these molecules are also highlighted and discussed.
“…For the furocoumarins, the initial LC-MS/MS method published in 2004 [ 67 ] was reworked by IFRA by using LC-QQQ and was a fully validated approach ( figure 6 ), but was not published. A variant based on HPLC-exact mass MS also meets the present recommendations [ 68 ]. Figure 6.…”
Over the past 15 years, chromatographic techniques with mass spectrometric detection have been increasingly used to monitor the rapidly expanded list of regulated flavour and fragrance ingredients. This trend entails a need for good quantification practices suitable for complex media, especially for multi-analytes. In this article, we present experimental precautions needed to perform the analyses and ways to process the data according to the most recent approaches. This notably includes the identification of analytes during their quantification and method validation, when applied to real matrices, based on accuracy profiles. A brief survey of application studies based on such practices is given.This article is part of the themed issue ‘Quantitative mass spectrometry’.
“…Fragrance [50] Phototoxicity, hyperpigmentation, erythematous rash, blisters, and sunburn if the user is exposed to UV-A radiation from the sun [51] RP-HPLC-coupled HR/AM, LC-MS, LC-MS/MS LRI [49,52,53] 11.…”
The general public uses cosmetics daily. Cosmetic products contain substances (ingredients) with various functions, from skincare to enhancing appearance, as well as ingredients that preserve the cosmetic products. Some cosmetic ingredients are prohibited or restricted in certain geographical regions, such as the European Union and the United States of America, due to their potential to cause adverse effects such as cancer, birth defects, and/or developmental and reproductive disorders. However, the ingredients may be used in other regions, and, hence, the monitoring of the cosmetic ingredients actually used is important to ensure the safety of cosmetic products. This review provides an overview of recent analytical methods that have been developed for detecting certain ingredients that are restricted or prohibited by the U.S. Food and Drug Administration (FDA) and/or EU legislation on cosmetic products.
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