Quantification of Fluid Resolution and Visual Acuity Gain in Patients With Diabetic Macular Edema Using Deep Learning

Roberts, Philipp; Vogl, Wolf Dieter; Gerendas, Bianca S.; Glassman, Adam R.; Bogunović, Hrvoje; Jampol, Lee M.; Schmidt–Erfurth, U.

doi:10.1001/jamaophthalmol.2020.2457

Cited by 51 publications

(47 citation statements)

References 46 publications

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“…Deep learning-based methods offer a new approach, enabling quick and accurate segmentation of pathological features 15,16 and providing more granular assessments of disease progression. 17,18 De Fauw et al 19 previously published a 2-stage deep learning system, involving segmentation as an intermediate representation, and assessed its accuracy when classifying macular diseases. Herein, we assessed the agreement of automated segmentations in deliberately challenging scans with AMD and DME against a reading center criterion standard that importantly involved manual human segmentation of entire OCT volumes, rather than selecting key sections as others have done.…”

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confidence: 99%

Validation and Clinical Applicability of Whole-Volume Automated Segmentation of Optical Coherence Tomography in Retinal Disease Using Deep Learning

et al. 2021

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IMPORTANCE Quantitative volumetric measures of retinal disease in optical coherence tomography (OCT) scans are infeasible to perform owing to the time required for manual grading. Expert-level deep learning systems for automatic OCT segmentation have recently been developed. However, the potential clinical applicability of these systems is largely unknown.OBJECTIVE To evaluate a deep learning model for whole-volume segmentation of 4 clinically important pathological features and assess clinical applicability. DESIGN, SETTING, PARTICIPANTSThis diagnostic study used OCT data from 173 patients with a total of 15 558 B-scans, treated at Moorfields Eye Hospital. The data set included 2 common OCT devices and 2 macular conditions: wet age-related macular degeneration (107 scans) and diabetic macular edema (66 scans), covering the full range of severity, and from 3 points during treatment. Two expert graders performed pixel-level segmentations of intraretinal fluid, subretinal fluid, subretinal hyperreflective material, and pigment epithelial detachment, including all B-scans in each OCT volume, taking as long as 50 hours per scan. Quantitative evaluation of whole-volume model segmentations was performed. Qualitative evaluation of clinical applicability by 3 retinal experts was also conducted.

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confidence: 99%

Validation and Clinical Applicability of Whole-Volume Automated Segmentation of Optical Coherence Tomography in Retinal Disease Using Deep Learning

et al. 2021

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“…A recent study monitored the HRF counts in diabetic retinopathy and diabetic macular edema in eyes that received anti-VEGF and steroid injections. This study reported a decrease in the number of HRF with either treatment, but a more marked decrease in the steroid group [42]. This biomarker provides an interesting avenue to monitor inflammatory activity in diabetic eye disease.…”

Section: Introductionmentioning

confidence: 59%

“…HRF count has been explored as a potential biomarker to assess inflammation in diabetic eye disease. Manual and automated approaches of the segmentation of these HRF have been tested [40][41][42]. A recent study monitored the HRF counts in diabetic retinopathy and diabetic macular edema in eyes that received anti-VEGF and steroid injections.…”

Section: Introductionmentioning

confidence: 99%

Quantitative Imaging Biomarkers in Age-Related Macular Degeneration and Diabetic Eye Disease: A Step Closer to Precision Medicine

Kalra

Kar

Sevgi

et al. 2021

JPM

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The management of retinal diseases relies heavily on digital imaging data, including optical coherence tomography (OCT) and fluorescein angiography (FA). Targeted feature extraction and the objective quantification of features provide important opportunities in biomarker discovery, disease burden assessment, and predicting treatment response. Additional important advantages include increased objectivity in interpretation, longitudinal tracking, and ability to incorporate computational models to create automated diagnostic and clinical decision support systems. Advances in computational technology, including deep learning and radiomics, open new doors for developing an imaging phenotype that may provide in-depth personalized disease characterization and enhance opportunities in precision medicine. In this review, we summarize current quantitative and radiomic imaging biomarkers described in the literature for age-related macular degeneration and diabetic eye disease using imaging modalities such as OCT, FA, and OCT angiography (OCTA). Various approaches used to identify and extract these biomarkers that utilize artificial intelligence and deep learning are also summarized in this review. These quantifiable biomarkers and automated approaches have unleashed new frontiers of personalized medicine where treatments are tailored, based on patient-specific longitudinally trackable biomarkers, and response monitoring can be achieved with a high degree of accuracy.

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“…The work of Schlegel is of particular importance given its recent deployment in a retrospective clinical analysis that was able to correlate fluid amounts to clinical outcomes. 28 A key difference in our study, however, is the additional segmentation of PED segmentation within the same network. This becomes feasible with this data set, because of the method of spatial injection that uses the layer segmentation software (Orion TM ).…”

Section: Discussionmentioning

confidence: 97%

Automated Deep Learning-based Multi-class Fluid Segmentation in Swept-Source Optical Coherence Tomography Images

Oakley¹,

Sodhi

Russakoff³

et al. 2020

Preprint

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PurposeTo evaluate the performance of a deep learning-based, fully automated, multi-class, macular fluid segmentation algorithm relative to expert annotations in a heterogeneous population of confirmed wet age-related macular degeneration (wAMD) subjects.MethodsTwenty-two swept-source optical coherence tomography (SS-OCT) volumes of the macula from 22 from different individuals with wAMD were manually annotated by two expert graders. These results were compared using cross-validation (CV) to automated segmentations using a deep learning-based algorithm encoding spatial information about retinal tissue as an additional input to the network. The algorithm detects and delineates fluid regions in the OCT data, differentiating between intra- and sub-retinal fluid (IRF, SRF), as well as fluid resulting from in serous pigment epithelial detachments (PED). Standard metrics for fluid detection and quantification were used to evaluate performance.ResultsThe per slice receiver operating characteristic (ROC) area under the curves (AUCs) for each of these fluid types were 0.90, 0.94 and 0.94 for IRF, SRF and PED, respectively. Per volume results were 0.94 and 0.88 for IRF and PED (SRF being present in all cases). The correlation of fluid volume between the expert graders and the algorithm were 0.99 for IRF, 0.99 for SRF and 0.82 for PED.ConclusionsAutomated, deep learning-based segmentation is able to accurately detect and quantify different macular fluid types in SS-OCT data on par with expert graders.

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Quantification of Fluid Resolution and Visual Acuity Gain in Patients With Diabetic Macular Edema Using Deep Learning

Cited by 51 publications

References 46 publications

Validation and Clinical Applicability of Whole-Volume Automated Segmentation of Optical Coherence Tomography in Retinal Disease Using Deep Learning

Validation and Clinical Applicability of Whole-Volume Automated Segmentation of Optical Coherence Tomography in Retinal Disease Using Deep Learning

Quantitative Imaging Biomarkers in Age-Related Macular Degeneration and Diabetic Eye Disease: A Step Closer to Precision Medicine

Automated Deep Learning-based Multi-class Fluid Segmentation in Swept-Source Optical Coherence Tomography Images

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