Quantification of erythema using digital camera and computer‐based colour image analysis: a multicentre study

Setaro, Michele; Sparavigna, Adele

doi:10.1034/j.1600-0846.2002.00328.x

Cited by 61 publications

(42 citation statements)

References 12 publications

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“…In ophthalmology, digital photography and analysis are used for diagnosis of the anterior eye segment [37], for vessel detection in corneal transplants [38], for analyzing the corneal involvement of pterygium conjunctivae [39,40], for noninvasive calculation of hemoglobin in the wide field of emergency medicine [41], for examining rotational stability of intraocular lenses [42], in diagnosis of dry eye [43] and in the observation of side effects of antiglaucomatous treatment [44]. In dermatology they are implemented for measuring erythema and edema of the skin prick test [45,46,47] or intradermal skin tests [48], for analyzing repigmentation during treatment of vitiligo [49], for quantification of skin lesions [50], and in diagnosis and treatment of atopic dermatitis [51,52]. Otorhinolaryngology makes use of this technique during endoscopic transsphenoidal pituitary surgery [53] and for video-laryngoscopic-assisted surgery [54], while it is used for analysis of body posture in patients with asthma [55,56] in pediatrics.…”

Section: Introductionmentioning

confidence: 99%

Objectifying the Conjunctival Provocation Test: Photography-Based Rating and Digital Analysis

Dogan

Astvatsatourov

Deserno

et al. 2013

Int Arch Allergy Immunol

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Background: Patients with allergic rhinoconjunctivitis are susceptible to both nasal and ocular symptoms. The conjunctival provocation test (CPT) is an established diagnostic procedure used in allergic rhinoconjunctivitis, particularly to document a patient's current reactivity to allergens. To date, there are no international guidelines defining the CPT. No approved evaluation method exists for interpreting CPT results. This paper aims to establish the digital analysis of macroimages as an objective, validated and standardized method for interpreting CPT results. Methods: In a clinical immunotherapy trial with 155 patients, treatment progress was documented based on the CPT. Local investigators used a symptom score to grade tearing, reddening and the patients' subjective perception of symptoms (mucosal irritation). A central observer rated conjunctival hyperemia via digital photography. Digital image analysis software was utilized to determine conjunctival hyperemia. Results: Spearman's correlation between the local investigators' and the central observer's ratings was r = 0.729 (p < 0.001); the percentage of total agreement was 48% (based on 739 photos). Digital image analysis (based on 48 photos) had a high percentage of total agreement with the central observer's ratings (69%) but a low percentage of total agreement with the investigators' ratings (38%). The corresponding correlations were r = 0.264 and 0.064, respectively. Conclusion: Photography-based rating by a central observer may represent a valuable supplement to the local investigator's assessment for making an objective evaluation of CPT results. Digital image analysis possesses the potential of being an objective evaluation method compared to the wide-spread subjective evaluation by the investigators.

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Section: Introductionmentioning

confidence: 99%

Objectifying the Conjunctival Provocation Test: Photography-Based Rating and Digital Analysis

Dogan

Astvatsatourov

Deserno

et al. 2013

Int Arch Allergy Immunol

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“…An alternative technology is to use a digital camera based system, which offers advantages such as computer interface for near real time feedback, flexibility of measurement area selection, and noncontact technique, [19][20][21][22][23]. However, for a digital imaging system to provide meaningful results, several factors must be controlled, such as camera sensitivity, shutter speed, aperture size, magnification, and patient positioning for consistent image analysis.…”

Section: Introductionmentioning

confidence: 99%

Characterization of port wine stain skin erythema and melanin content using cross‐polarized diffuse reflectance imaging

et al. 2004

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Background and Objectives: Objective methods to assess quantitatively port wine stain (PWS) blanching in response to laser therapy are needed to improve laser therapeutic outcome. Previous studies have attempted to assess objectively PWS color based on point measurement devices. To date, these approaches have typically been limited by a number of factors such as small test area and need for contact. To address these issues, a cross-polarized diffuse reflectance imaging system and color image analysis method has been developed to evaluate quantitatively erythema and melanin content in PWS skin. Study Design/Materials and Methods: A cross-polarized diffuse reflectance system has been constructed to acquire high resolution digital images while minimizing artifacts such as glare, shadowing, and nonuniform illumination effects that can compromise image fidelity. Furthermore, an image analysis algorithm has also been developed to analyze normal and PWS skin in terms of CIEL*a*b* color space parameters. Using the algorithm, images of color space intensity, L*, and saturation, a*, indices have been calculated to extract quantitative metrics of melanin and erythema, respectively. Results: Compared to the cross-polarized diffuse reflectance image, the a* index image enhanced the contrast in regions of high and low erythema and seems to have quasi correlation with the L* index image. In the presented PWS patient example, the relative a* index difference (Da*) image showed less erythema in PWS skin after laser treatment when compared to pre-treatment values. Conclusions: Our cross-polarized imaging system and color image analysis method is a simple, noncontact technique that can indirectly provide quantitative measurement of erythema and melanin content in PWS skin.

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“…[9][10][11][12][13] The former retrieves spectral information from point measurements * while the latter is obtained with conventional RGB colour cameras. RGB cameras divide the light spectrum into broad overlapping red, green, and blue image slices that when combined seem realistic to the eye.…”

Section: Introductionmentioning

confidence: 99%

Hyperspectral image processing for detection and grading of skin erythema

et al. 2017

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Visual assessment is the most common clinical investigation of skin reactions in radiotherapy. Due to the subjective nature of this method, additional noninvasive techniques are needed for more accurate evaluation. Our goal is to evaluate the effectiveness of hyperspectral image analysis for that purpose. In this pilot study, we focused on detection and grading of skin Erythema. This paper reports our proposed processing pipeline and experimental findings. Experiments have been performed to demonstrate the efficacy of the proposed approach for (1) reproducing clinical assessments, and (2) outperforming RGB imaging data.

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Quantification of erythema using digital camera and computer‐based colour image analysis: a multicentre study

Cited by 61 publications

References 12 publications

Objectifying the Conjunctival Provocation Test: Photography-Based Rating and Digital Analysis

Objectifying the Conjunctival Provocation Test: Photography-Based Rating and Digital Analysis

Characterization of port wine stain skin erythema and melanin content using cross‐polarized diffuse reflectance imaging

Hyperspectral image processing for detection and grading of skin erythema

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