Quantification of endolymphatic hydrops and its correlation with Meniere’s disease clinical features

Sun, Qiyang; Jiang, Guangli; Xiong, Guanxia; Sun, Wei; Wang, Wen; Wei, Fanqin

doi:10.1111/coa.13847

Cited by 13 publications

(14 citation statements)

References 25 publications

(21 reference statements)

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“…However, degree of cochlear EH decreased with MD stage when it changed from stage 3 to 4, as did degree of cochlear and vestibular EH at the second hospitalization. However, our results were not entirely consistent with a previous study ( 39 ). This may have been because Sun et al ( 39 ) analyzed the relationship between total EH index and MD stage and did not separately analyze the relationship of cochlear EH index or vestibular EH index with MD stage.…”

Section: Discussioncontrasting

confidence: 99%

“…However, our results were not entirely consistent with a previous study ( 39 ). This may have been because Sun et al ( 39 ) analyzed the relationship between total EH index and MD stage and did not separately analyze the relationship of cochlear EH index or vestibular EH index with MD stage. Alternatively, Sun et al only analyzed once examination showing the relationship between EH and MD stage, which was consistent with our vestibular EH at the first hospitalization.…”

Section: Discussioncontrasting

confidence: 99%

“…However, our results were not entirely consistent with a previous study (39). This may have been because Sun et al (39) analyzed the relationship between total EH index and MD stage and did not separately analyze the relationship of cochlear EH index or vestibular EH index at the terminal MD stage, or the endolymphatic sinus is enlarged due to excess of endolymph volume, leading to an amount of endolymph being displaced from the sinus into the endolymphatic sac (45). Consequently, EH is necessary for MD.…”

Section: Eh and Ptacontrasting

confidence: 99%

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Longitudinal variation of endolymphatic hydrops in patients with Ménière’s disease

Li¹,

Wang²,

Hu³

et al. 2023

Ann Transl Med

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Background: The relationships of endolymphatic hydrops (EH) and perilymphatic enhancement (PE) with Ménière's disease (MD) remains unclear. This study aimed to describe the dynamic variation of EH and PE for MD patients over 2 hospitalizations by applying magnetic resonance imaging (MRI) to further clarify the relationships of EH and PE with MD.Methods: A total of 77 MD patients who underwent inner ear MRI after intravenous administration of gadolinium and pure-tone average (PTA) testing during a first and second hospitalization were included.The degree of EH and PE were evaluated via MRI, and the duration and frequency of vertigo attacks and PTA were collected and recorded. The PTA, EH, and PE for the 2 hospitalizations were compared, and the relationships of EH and cochlear PE with the MD stage were investigated.Results: There was no difference between the 2 hospitalizations for duration of vertigo attacks or frequency of vertigo attacks. However, there were significant differences in PTA (Z=−3.02, P=0.003). Additionally, the cochlear and vestibular EH in the asymptomatic ear at the second hospitalization was significantly worse than that of the first hospitalization (Z=−2.33 and −2.49, P=0.020 and 0.013, respectively), while there were no differences in EH and PE in the affected ear (all P>0.05). Moreover, the degree of cochlear and vestibular EH was correlated with MD stage (both P<0.01).Conclusions: Although EH and PE in the affected ear were unchanged over 2 hospitalizations, an underlying EH in the asymptomatic ear and hearing loss in the affected ear for MD patients developed longitudinally with the duration of disease, and EH varied with the natural course of MD whereas PE did not. Therefore, EH instead of PE is necessary but insufficient to cause the clinical symptoms of MD.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 99%

“…However, our results were not entirely consistent with a previous study (39). This may have been because Sun et al (39) analyzed the relationship between total EH index and MD stage and did not separately analyze the relationship of cochlear EH index or vestibular EH index at the terminal MD stage, or the endolymphatic sinus is enlarged due to excess of endolymph volume, leading to an amount of endolymph being displaced from the sinus into the endolymphatic sac (45). Consequently, EH is necessary for MD.…”

Section: Eh and Ptacontrasting

confidence: 99%

See 1 more Smart Citation

Longitudinal variation of endolymphatic hydrops in patients with Ménière’s disease

Li¹,

Wang²,

Hu³

et al. 2023

Ann Transl Med

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show abstract

“…At present, endolymphatic hydrops can be visualized by injecting gadolinium contrast agent, which increases the diagnostic rate of Meniere's disease ( 33 ). Scholars have confirmed that the degree of endolymphatic hydrops is related to the stage of Meniere's disease, low-frequency hearing threshold, EchoG, and VEMP asymmetry ratio ( 34 , 35 ). Meniere's disease is mostly attributed to endolymphatic hydrops in the inner ear.…”

Section: Discussionmentioning

confidence: 94%

Worldwide Meniere's disease research: A bibliometric analysis of the published literature between 2002 and 2021

Zou

Peng

et al. 2022

Front. Neurol.

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BackgroundIn recent years, there has been an increasing number of publications on Meniere's disease. However, there are no bibliometric research on Meniere's disease. The purpose of this study was to find the focus and trends of Meniere's disease research through bibliometric approach.MethodsPublications related to Meniere's disease in the Web of Science Core Collection (WOSCC) from 2002 to 2021 were collected. The bibliometric approach was used to estimate the searched data. Research foci of the studies were identified using VOSviewer and CiteSpace software.ResultsA total of 1,987 articles meet the inclusion criteria and are included in the study. In the past 20 years, the number of Meniere's disease publications is gradually increasing, especially in the past 3 years. The country with the largest contribution to Meniere's disease research is the United States, followed by Europe and Japan. High-frequency keywords included Meniere's disease, endolymphaic hydrops, vertigo, meniere-disease, inner ear, dizziness, symptoms, hearing, diagnosis, and tentamicin. The analyses of keyword burst direction indicate that evoked myogenic potential, MRI, and committee are emerging research hotspots.ConclusionThis study provides an objective, systematic, and comprehensive analysis of Meniere's disease-related literature. In addition, we find a dramatic increase in studies in this field over the past 3 years. Evoked myogenic potentials and MRI may become the research hotspots of Meniere's disease in future. This study will help otolaryngologists, neurologists, and audiologists to clarify the research direction and potential hotspots of Meniere's disease and further help clinicians improve patients' prognosis.

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“…Meniere's disease is a clinical syndrome characterized by recurrent episodes of spontaneous vertigo, unilateral fluctuating sensorineural hearing loss, tinnitus, and sufficient hearing 1,2 . Endolymphatic hydrops is considered as the pathophysiological basis of the disease, which has been confirmed in anatomical pathology studies and recent magnetic resonance imaging (MRI) 3,4 .…”

Section: Resultsmentioning

confidence: 99%

Expression of AQP8 in serum of patients with Meniere's disease and its value in evaluating the degree of hydrolabyrinth and predicting prognosis

Zhao

et al. 2022

Preprint

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Objective To explore the value of serum aquaporin 8 (AQP8) expression in evaluating the degree of hydrolabyrinth and predicting prognosis in patients with Meniere’s disease. Methods 105 patients with Meniere’s disease in our hospital were included in the Meniere’s disease group.Another 102 healthy subjects in our hospital were included as the control group. The multivariate Logistic regression was used to analyze the influencing factors of poor prognosis in patients with Meniere’s disease. Results The expression of serum AQP8 mRNA in the Meniere’s disease group was greatly higher than that in the control group (P<0.05). Serum AQP8 mRNA expression in severe hydrops group was greatly higher than that in mild hydrops group and no endolymphatic hydrops group, and serum AQP8 mRNA expression in mild hydrops group was greatly higher than that in no endolymphatic hydrops group (P<0.05). The course of disease, the proportion of severe hydrops and the expression of serum AQP8 mRNA in the poor prognosis group were greatly higher than those in the good prognosis group (P<0.05). The area under the curve (AUC) of serum AQP8 mRNA for predicting poor prognosis in Meniere’s disease patients was 0.812 (95%CI: 0.702-0.922), with a sensitivity of 81.0% and a specificity of 70.2%. AQP8 mRNA was an independent risk factor for poor prognosis in patients with Meniere’s disease (P<0.05). Conclusion AQP8 mRNA is associated with the degree of hydrolabyrinth in patients with Meniere’s disease, and has a high performance in predicting prognosis.

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Quantification of endolymphatic hydrops and its correlation with Meniere’s disease clinical features

Cited by 13 publications

References 25 publications

Longitudinal variation of endolymphatic hydrops in patients with Ménière’s disease

Longitudinal variation of endolymphatic hydrops in patients with Ménière’s disease

Worldwide Meniere's disease research: A bibliometric analysis of the published literature between 2002 and 2021

Expression of AQP8 in serum of patients with Meniere's disease and its value in evaluating the degree of hydrolabyrinth and predicting prognosis

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