Quantification of disease activity in patients undergoing leucocyte scintigraphy for suspected inflammatory bowel disease

Cheow, Heok; Voutnis, Demetrius; Evans, John W.; Szczepura, Katy; Swift, Ealish; Bird, Nicholas J.; Ruparelia, Prina; Solanki, Chandra K.; Ballinger, James R.; Chilvers, Edwin R.; Middleton, Stephen; Peters, A. M.

doi:10.1007/s00259-004-1617-7

Cited by 8 publications

(4 citation statements)

References 14 publications

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“…Some authors aimed to quantify the severity of IBD by means of different parameters, like in-house validated scintigraphic indices (SI) at 99m Tc-HMPAO-WBC scan[13] or the stool radioactivity (defined as the disappearance of 111 In-radiolabelled leukocytes from the spleen[14] or from the whole body retention[14,15], as they migrates toward regions of inflammation). As a matter of fact, such semi-quantitative methods for the assessment of the severity of disease could be important for an objective evaluation of treatment response, although a more extensive demonstration of their usefulness lacks in the literature.…”

Section: Resultsmentioning

confidence: 99%

Role of molecular imaging in the management of patients affected by inflammatory bowel disease: State-of-the-art

Caobelli

Evangelista

Quartuccio

et al. 2016

WJR

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AIMTo present the current state-of-the art of molecular imaging in the management of patients affected by inflammatory bowel disease (IBD).METHODSA systematic review of the literature was performed in order to find important original articles on the role of molecular imaging in the management of patients affected by IBD. The search was updated until February 2016 and limited to articles in English.RESULTSFifty-five original articles were included in this review, highlighting the role of single photon emission tomography and positron emission tomography.CONCLUSIONTo date, molecular imaging represents a useful tool to detect active disease in IBD. However, the available data need to be validated in prospective multicenter studies on larger patient samples.

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Section: Resultsmentioning

confidence: 99%

Role of molecular imaging in the management of patients affected by inflammatory bowel disease: State-of-the-art

Caobelli

Evangelista

Quartuccio

et al. 2016

WJR

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“…Among NPM, labeled leukocytes scintigraphy is the method of choice for the detection of ulcerative colitis with 111In-labeled granulocytes totally replaced by 99m Tc-HMPAO-labeled granulocytes [ 16 , 17 ] while positron emission tomography (PET) scintigraphy is a newer challenging nuclear modality with fulfilling sensitivity and specificity [ 18 , 19 ]. Other radiopharmaceuticals as the tumor seeking labeled agent 99m Tc-[V]-DMSA have been also used [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Ulcerative Colitis Activity Presenting as Fever of Unknown Origin, in a Patient with Longstanding Disease under Continuous Treatment with Mesalazine

Voukelatou

Sfendouraki

Karianos

et al. 2016

Case Reports in Medicine

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Background. The presence of ulcerative colitis (UC) with no bowel symptoms, as fever of unknown origin (FUO), is uncommon. Objective. To describe the case of an 80-year-old woman who presented with fever, with a history of UC under treatment with mesalazine. Case Presentation. She was admitted due to fever lasting for 12 days with no associated symptoms. Seven years earlier, she was diagnosed with UC. After an extended workup for FUO that failed to reach the diagnosis, she underwent a gallium-67 scintigraphy. This revealed a persistent diffuse concentration of gallium-67 in the ascending colon at 24-hour imaging that remained stable at 48- and 72-hour imaging without any topographic change after the use of laxatives. Considering the results and in the absence of another diagnosis, the patient was treated with 30 mg prednisone daily and mesalazine, as treatment of active UC. Subsequently, the patient's condition improved markedly and the fever retreated. One month later, she was reevaluated with a gallium-67 scintigraphy with total absence of gallium-67 concentration in the ascending colon. Conclusion. UC activity must be included in the differential diagnosis of FUO in patients with longstanding disease, since fever may present alone, with no other manifestations.

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“…Neben der üblichen visuellen Befundung der Leukozytenszinitgrafie wurden auch Verfahren zur quantitativen Auswertung beschrieben [12,22]. Die Szintigrafie mit 99m Tc-markierten Leukoyzten scheint sich zur frühen Beurteilung des Anspre-▶ Tab.…”

Section: Entzündliche Darmerkrankungenunclassified

Nuklearmedizinische Entzündungsdiagnostik: Update 2017

Ivančević

2017

Nuklearmediziner

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ZusammenfassungDie Szintigrafie mit radioaktiv markierten Leukozyten und Antigranulozytenantikörpern bildet den Eckpfeiler der nuklearmedizinischen Diagnostik entzündlicher und infektiöser Erkrankungen. Obwohl sich die FDG-PET/CT in der Diagnostik entzündlicher Erkrankungen in immer mehr Indikationen etabliert, bleibt die Szintigrafie mit markierten Leukozyten und Antigranulozytenantikörpern – auch wegen eingeschränkter Verfügbarkeit der FDG – bei entzündlichen Erkrankungen, die mit hoher Wahrscheinlichkeit erregerbedingt sind, die nuklearmedizinische Bildgebung der Wahl. In dieser Übersichtsarbeit werden die Entwicklung und der derzeitige Stellenwert der Leukozyten- und Antigranulozytenantikörperszintigrafie bei den wichtigsten dafür geeigneten Fragestellungen beleuchtet. Abschließend wird auch der aktuelle Kenntnisstand zum Beitrag der Hybridbildgebung SPECT/CT in der Diagnostik entzündlicher Erkrankungen wiedergegeben.

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Quantification of disease activity in patients undergoing leucocyte scintigraphy for suspected inflammatory bowel disease

Abstract: Dedicated whole-body counting is able to quantify disease activity in IBD but may give normal values in active CD.

Cited by 8 publications

References 14 publications

Role of molecular imaging in the management of patients affected by inflammatory bowel disease: State-of-the-art

Role of molecular imaging in the management of patients affected by inflammatory bowel disease: State-of-the-art

Ulcerative Colitis Activity Presenting as Fever of Unknown Origin, in a Patient with Longstanding Disease under Continuous Treatment with Mesalazine

Nuklearmedizinische Entzündungsdiagnostik: Update 2017

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