Quantification of Coronary Artery Calcium on the Basis of Dual-Energy Coronary CT Angiography

Schwarz, Florian; Nance, John W.; Ruzsics, Balázs; Bastarrika, Gorka; Sterzik, Alexander; Schoepf, U. Joseph

doi:10.1148/radiol.12112455

Cited by 72 publications

(52 citation statements)

References 27 publications

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“…Accuracy of detection may be further improved by the adoption of dual-energy MDCT techniques. [29][30][31] Ideally, a sophisticated, automated model would be implemented, such as that …”

Section: A N U S C R I P Tmentioning

confidence: 99%

Practical determination of aortic valve calcium volume score on contrast-enhanced computed tomography prior to transcatheter aortic valve replacement and impact on paravalvular regurgitation: Elucidating optimal threshold cutoffs

Bettinger

Khalique

Krepp

et al. 2017

Journal of Cardiovascular Computed Tomography

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“…Accuracy of detection may be further improved by the adoption of dual-energy MDCT techniques. [29][30][31] Ideally, a sophisticated, automated model would be implemented, such as that …”

Section: A N U S C R I P Tmentioning

confidence: 99%

Practical determination of aortic valve calcium volume score on contrast-enhanced computed tomography prior to transcatheter aortic valve replacement and impact on paravalvular regurgitation: Elucidating optimal threshold cutoffs

Bettinger

Khalique

Krepp

et al. 2017

Journal of Cardiovascular Computed Tomography

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“…The behavior of the individual materials at different energy levels depends on their atomic number, the electron density, their density, and their diameter. 12 Dual-energy CT has become an established tool for characterization of urinary calculi, 13,14 quantification of coronary artery calcium, 15 measurement of contrast agent uptake, 16 or discrimination between contrast media and intracerebral hemorrhage. 17 Elements with a considerable difference in their atomic number can be characterized with the dual-energy index (DEI).…”

mentioning

confidence: 99%

Added Value of Dual-Energy Computed Tomography Versus Single-Energy Computed Tomography in Assessing Ferromagnetic Properties of Ballistic Projectiles

Winklhofer¹,

Stolzmann

Meier

et al. 2014

Investigative Radiology

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Measurements of DECT combined with an extended CT scale allow for the discrimination of projectiles with non-ferromagnetic from those with ferromagnetic properties in an anthropomorphic chest phantom with a higher AUC compared with SECT. This study indicates that DECT may have the potential to contribute to MR safety and allow for MR imaging of patients with retained projectiles. However, further studies are necessary before this concept may be used to triage clinical patients before MR.

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“…Deconvolution filters require long computational times and have not been validated in clinical practice [25]. Dual-energy scan techniques allow the acquisition of separate low-and high-energy images which are then synthesized to cancel high-density structures such as calcifications [26,27]. Compared to the conventional (single-energy) scan technique, these approaches are characterised by roughly double temporal resolution or spatial resolution, hence the added value for coronary artery imaging in patients remains uncertain.…”

Section: Discussionmentioning

confidence: 99%

Computed tomography segmental calcium score (SCS) to predict stenosis severity of calcified coronary lesions

Pugliese

Hunink

Meijboom

et al. 2015

Int J Cardiovasc Imaging

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To estimate the probability of ≥ 50% coronary stenoses based on computed tomography (CT) segmental calcium score (SCS) and clinical factors. The Institutional Review Board approved the study. A training sample of 201 patients underwent CT calcium scoring and conventional coronary angiography (CCA). All patients consented to undergo CT before CCA after being informed of the additional radiation dose. SCS and calcification morphology were assessed in individual coronary segments. We explored the predictive value of patient's symptoms, clinical history, SCS and calcification morphology. We developed a prediction model in the training sample based on these variables then tested it in an independent test sample. The odds ratio (OR) for ≥ 50% coronary stenosis was 1.8-fold greater (p = 0.006) in patients with typical chest pain, twofold (p = 0.014) greater in patients with acute coronary syndromes, twofold greater (p < 0.001) in patients with prior myocardial infarction. Spotty calcifications had an OR for ≥ 50% stenosis 2.3-fold (p < 0.001) greater than the absence of calcifications, wide calcifications 2.7-fold (p < 0.001) greater, diffuse calcifications 4.6-fold (p < 0.001) greater. In middle segments, each unit of SCS had an OR 1.2-fold (p < 0.001) greater than in distal segments; in proximal segments the OR was 1.1-fold greater (p = 0.021). The ROC curve area of the prediction model was 0.795 (0.95 confidence interval 0.602-0.843). Validation in a test sample of 201 independent patients showed consistent diagnostic performance. In conjunction with calcification morphology, anatomical location, patient's symptoms and clinical history, SCS can be helpful to estimate the probability of ≥ 50% coronary stenosis.

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Quantification of Coronary Artery Calcium on the Basis of Dual-Energy Coronary CT Angiography

Abstract: Coronary artery calcium identification and quantification based on dual-energy coronary CT angiographic studies may obviate the need for dedicated CT calcium scoring studies.

Cited by 72 publications

References 27 publications

Practical determination of aortic valve calcium volume score on contrast-enhanced computed tomography prior to transcatheter aortic valve replacement and impact on paravalvular regurgitation: Elucidating optimal threshold cutoffs

Practical determination of aortic valve calcium volume score on contrast-enhanced computed tomography prior to transcatheter aortic valve replacement and impact on paravalvular regurgitation: Elucidating optimal threshold cutoffs

Added Value of Dual-Energy Computed Tomography Versus Single-Energy Computed Tomography in Assessing Ferromagnetic Properties of Ballistic Projectiles

Computed tomography segmental calcium score (SCS) to predict stenosis severity of calcified coronary lesions

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