Quantification of Contrast Recognizability during Brilliant Blue G– and Indocyanine Green–Assisted Chromovitrectomy

Henrich, P. B.; Priglinger, Siegfried; Haritoglou, Christos; Josifova, Tatjana; Ferreira, Paulo R.; Strauss, Rupert W.; Flammer, Josef; Cattin, Philippe C.

doi:10.1167/iovs.10-6972

Cited by 30 publications

(33 citation statements)

References 35 publications

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“…19,27,28 However, while BBG also selectively stains the ILM, 27 staining intensity has been reported to be significantly inferior to that of ICG. 14,19 • After its recent Food and Drug Administration's approval, TB is now also approved for intravitreal use in both Europe and the United States. Trypan blue had been used for staining of the anterior capsule in cataract surgery for over a decade before.…”

Section: Discussionmentioning

confidence: 99%

“…14 Frames displaying good image quality were selected, and regions of interest (ROIs) representing maximum contrast were signaled within the temporal vascular arcades under the supervision of a vitreoretinal surgeon (P.B.H.). For classification of ERM versus ILM, all videos were reviewed with the surgeon.…”

Section: Methodsmentioning

confidence: 99%

“…Equivalence of both methods had been described previously, 14 allowing pooling of data. To quantitatively compare the perceived color contrast of the selected ROIs, the software first calculated the average color within each ROI.…”

Section: Methodsmentioning

confidence: 99%

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Quantification of Contrast Recognizability in Sequential Epiretinal Membrane Removal and Internal Limiting Membrane Peeling in Trypan Blue–assisted Macular Surgery

Henrich

Priglinger

Haritoglou

et al. 2013

Retina

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Purpose: To evaluate the selectivity and strength of intraoperative trypan blue staining during removal of epiretinal membranes (ERMs) and the internal limiting membrane.Methods: Based on intraoperative videos, 51 consecutive chromovitrectomies in 51 patients with macular holes, macular pucker, vitreomacular traction syndromes, or persistent macular edema were retrospectively studied. Fifteen subjects underwent trypan blue, 14 indocyanine green, and 22 brilliant blue G chromovitrectomy. The main outcome measure was the color contrast between stained internal limiting membrane or ERM and the underlying unstained tissue by means of objective, quantitative, semiautomated chromaticity difference measurements.Results: Trypan blue stains both ERM and the internal limiting membrane (average chromaticity scores 8.51 and 7.09, respectively; P = 0.48). Internal limiting membrane chromaticity scores were similar for trypan blue (7.09) and brilliant blue G (6.81; P = 0.71) but clearly higher for indocyanine green (15.81; P = 2.45 · 10 −5 ).Conclusion: Under the premises of our study, trypan blue stains both ERM and the internal limiting membrane. Trypan blue's staining capacity of the internal limiting membrane is similar to that of brilliant blue G but significantly inferior compared with indocyanine green. Trypan blue, thus, represents a useful vital dye for chromovitrectomy, particularly in the presence of ERM, where it allows a sequential approach.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Quantification of Contrast Recognizability in Sequential Epiretinal Membrane Removal and Internal Limiting Membrane Peeling in Trypan Blue–assisted Macular Surgery

Henrich

Priglinger

Haritoglou

et al. 2013

Retina

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“…It has been shown that a significant proportion of the toxicity is related to the light-absorbing properties of the dye and the corresponding generating light source. Thus, it is advisable to minimize the light intensity and maximize the working distance when using vital dyes, to limit possible phototoxicity [7]. Even the photodynamic properties of ICG, BBG and TB have been evaluated in vitro.…”

Section: Discussionmentioning

confidence: 99%

A Trichrome RGB Endoillumination Prototype System: A Novel Application for Chromovitrectomy

Saxena¹,

Meyer²

2013

Ophthalmologica

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Introduction: LED cold light sources are utilized nowadays for endoillumination in vitreoretinal surgery. We investigated the effects of an individual mixing of red, green and blue (RGB) light from an LED illumination prototype for chromovitrectomy. Methods and Technique: A novel RGB LED cold light illumination system (Dieter Mann GmbH, Mainaschaff, Germany) contains 3 RGB light sources, allowing for an individual mixing of light, so that the surgeon can adjust and control the color quality and intensity of the applied light during chromovitrectomy. Results: Adding or subtracting the amount of any RGB light will consecutively change the resulting color of the light in the eye. The visualization of the retina or semitransparent naïve structures like the vitreous depends on the illumination. The visualization of epiretinal membranes stained with vital dyes can be enhanced by an individual adjustment of the applied light. Conclusion: Selective subtraction of one RGB light unit may increase the visibility of delicate structures during pars plana vitrectomy.

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“…[9][10][11] On the other hand, randomized clinical studies providing evidence that clinical outcomes are better with BBG than with ICG in ILM-peeling procedures are still lacking. Importantly, the staining properties of ICG seem superior to those of BBG 12 -a possible reason for the former's continued widespread use.…”

Section: Introductionmentioning

confidence: 99%

In vivo biocompatibility of a new cyanine dye for ILM peeling

Thaler

Haritoglou

Schuettauf

et al. 2014

Eye

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Quantification of Contrast Recognizability during Brilliant Blue G– and Indocyanine Green–Assisted Chromovitrectomy

Abstract: As an adjunct to chromovitrectomy to stain the ILM, BBG yields a significantly less well discernible contrast to the human eye than that of ICG under the premises of this study.

Cited by 30 publications

References 35 publications

Quantification of Contrast Recognizability in Sequential Epiretinal Membrane Removal and Internal Limiting Membrane Peeling in Trypan Blue–assisted Macular Surgery

Quantification of Contrast Recognizability in Sequential Epiretinal Membrane Removal and Internal Limiting Membrane Peeling in Trypan Blue–assisted Macular Surgery

A Trichrome RGB Endoillumination Prototype System: A Novel Application for Chromovitrectomy

In vivo biocompatibility of a new cyanine dye for ILM peeling

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