Quantification of Chimerism and Graft Immune Cell Composition with Alloseq HCT, a Highly Sensitive and Precise Next-Generation Sequencing Assay, in Patients Post-Hematopoietic Stem Cell Transplantation
Abstract:Introduction: Chimerism changes post hematopoietic cell transplant (HCT) can be an early indication of disease relapse. Graft immune cell fraction composition has been seen associated with clinical outcome of hematopoietic cell transplantation patients (Saliba et al., Haematologica February 2020). AlloSeq HCT (CareDx Inc., CA, USA) is the latest innovation in chimerism testing, an NGS-based chimerism assay that uses a targeted SNP panel and provides standardized workflow with automated data analyses.
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